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2 protocols using silver trifluoromethanesulfonate

1

Synthesis of Ionic Liquids and Reagents

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Acetonitrile
(99.9%), dichloromethane (99.8%), ethyl acetate (99.5%), 1-methylimidazole
(99%), 1-bromodecane (98%), 1-chlorobutane (98%), hexane (99.7%),
1-hexene (99.8%), 2-hexyne (99%), methyl tiglate (99%), PEG, silver
nitrate ([Ag+][NO3], 99%),
[Ag+][NTf2] (97%), silver
tetrafluoroborate ([Ag+][BF4], 98%), silver trifluoromethanesulfonate ([Ag+][TfO], 99%), 1-butyl-3-methylimidazolium nitrate ([BMIM+][NO3], 95%), [BMIM+][TfO] (95%), and [BMIM+][BF4] (97%) were purchased from Sigma-Aldrich (St.
Louis, MO, USA). Sodium tetrafluoroborate ([Na+][BF4], 97%) was purchased from Acros Organics
(Morris Plains, NJ, USA). [Li+][NTf2] (99.5%) salt was obtained from SynQuest Laboratories (Alachua,
FL, USA). Naphthalene (98%) and untreated fused silica capillary tubing
(I.D. 250 μm) were purchased from Supelco (Bellefonte, PA, USA).
All chemicals were used as received.
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2

Neuroimaging of Rhesus Monkeys

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Twelve young-adult male rhesus monkeys (Macaca mulatta: age range, 7.1-9.4 y old; weight range, 4.0-6.0 kg) were maintained and handled in accordance with the recommendations of the U.S. National Institutes of Health and the guidelines of the Central Research Laboratory, Hamamatsu Photonics K.K. The experiments were approved by the Ethical Committee of the Central Research Laboratory, Hamamatsu Photonics K.K. (approval HPK-2015-15) .
MR images of the monkeys were obtained with a 3.0-T scanner (Signa Excite HDxt 3.0T; GE Healthcare Japan) using a 3-dimensional spoiled gradient echo sequence under pentobarbital anesthesia.
Kryptofix222 and K 2 CO 3 Á1.5H 2 O were from Merck Milipore. Anhydrous CH 3 CN, dimethylformamide, dimethyl sulfoxide, silver trifluoromethanesulfonate, Tris(dibenzyldeneacetone)dipalladium(0), trio-tolylphosphine, and MPTP were from Sigma-Aldrich Japan. Precursors of 11 C-DASB, 18 F-MPPF, 6-11 C-methyl-m-tyrosin ( 11 C-6MemTyr), 11 Craclopride, 11 18 F-BCPP-EF, and their corresponding standard compounds were from NARD Institute Ltd.
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