All the single-stranded oligonucleotides of the Td listed in Table S1 were synthesized by Sangon Biotech Co. (Shanghai, China). The Luria-Bertani culture (LB, pH = 7.4) was bought from Sinopharm (Beijing, China), HEPES (pH = 7.4), NaCl, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) was bought from Sigma-Aldrich LLC. (Shanghai, China). Biotin, quinine sulfate, N-hydroxysulfosuccinimide (NHS) were provided by Tianjin Macklin (Shanghai, China). streptavidin-functionalized magnetic beads (SA−MBs) with a diameter of 2–3 μm were purchased from BaseLine ChromTech Research Centre (Tianjin, China). DNA loading buffer (6×) and DNA Markers were provided by Sangon Biotechnology Co., Ltd. (Shanghai, China). All solutions with a resistivity of 18.2 MΩ cm were prepared using a Milli-Q water purification system (Sartorius, Germany).
Milli q water purification system
Manufactured by Sartorius
Sourced in Germany
The Milli-Q water purification system is a lab equipment product designed to produce ultrapure water. It utilizes a multi-step purification process to remove impurities and contaminants from water, resulting in high-quality water suitable for various laboratory applications.
Automatically generated - may contain errors
Lab products found in correlation
Fenofibrate, by Merck Group (2 mentions)
Dna marker, by Sangon (1 mentions)
Hepes, by Merck Group (1 mentions)
Dna loading buffer 6, by Sangon (1 mentions)
Sodium chloride (nacl), by Avantor (1 mentions)
Methanol, by Avantor (1 mentions)
Sodium dihydrogen phosphate, by Avantor (1 mentions)
Fenofibric acid, by Merck Group (1 mentions)
Cremophor el, by Merck Group (1 mentions)
Cremophor rh40, by Merck Group (1 mentions)
Imwitor 308 i308, by Sasol (1 mentions)
3 protocols using milli q water purification system
1
Sensitive DNA Oligonucleotide Detection Protocol
2
Analytical Method for Fenofibrate and Metabolites
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All chemicals used in this study were obtained from commercial suppliers. Fenofibrate, (2-[4-(4-chlorobenzoyl) phenoxy]-2-methylpropionic acid 1-methylethyl ester) and its metabolite, fenofibric acid (FA, purity >99.5%), were supplied by Sigma-Aldrich Co. (St Louis, MO, USA). The internal standard fluvastatin was obtained from Riyadh Pharma Industry Ltd. (Riyadh, Saudi Arabia). Details of the lipids (oils and nonionic surfactants), their compositions, and suppliers are provided in Table 1 . All excipients were used without further purification. High performance liquid chromatography (HPLC) grade methanol, sodium dihydrogen phosphate, and sodium chloride were purchased from BDH Laboratory Supplies (Poole, UK). The 1 M HCl, which was diluted to obtain 0.1 M solution, was provided by Avonchem (Macclesfield, Cheshire, UK). Rat plasma containing ethylenediaminetetraacetic acid as anticoagulant was collected in-house. Water used in this study was obtained from a Milli-Q water purification system (Sartorius, Geottingen, Germany). All other chemicals and solvents were of analytical purity.
3
Fenofibrate Bioavailability Enhancement via SNEDDS
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All chemicals used in the studies were obtained from commercial suppliers. Fenofibrate (2-[4-(4-chlorobezoyl) phenoxy]-2-methylpropionic acid 1-methylethyl ester) was supplied by Sigma-Aldrich Co, USA. Miglyol 812 (M812), Imwitor 988 (I988), Imwitor 308 (I308) and propylene glycol (PG, 98 % pure) were supplied by Sasol Germany GmbH, Germany. The non-ionic surfactants used were TO-106V (PEG 6 sorbitan monooleate, HLB-10) and HCO-30 (PEG 30 hydrogenated castor oil, HLB-11), supplied by Nikko Chemicals Co., Japan. All excipients were used without further purifi cation. Cremophor EL (CrEL, polyoxyethylene 35 castor oil), and Cremophor RH40 (CrRH40, polyoxyethylene 40 castor oil) were from Sigma Chemical Co. (USA). Neusilin ® grade US2 (NUS2, synthetic magnesium aluminometasilicate, Fuji Chemical Co., Japan) was used as the microporous adsorbent to load SEDDS/SNEDDS. Lipanthyl ® (marketed product of fenofi brate, 200 mg micronized capsule) manufactured by Abbo (USA) was used in the study. Water used in this study was obtained from a Milli-Q water purifi cation system (Sartorius, Germany). All other chemicals and solvents were of analytical purity.
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