Tween 80, Tween 20, Transcutol P, Cremophor EL, PEG 400 and α-linolenic acid were purchased from Sigma (Sigma Aldrich, Dorset, UK). The derivatisation reagent, BCl3-methanol 12% w/w (12% boron trichloride in methanol), n-hexane (HPLC grade, purity, ≥99%) were also purchased from Sigma (Sigma Aldrich, Dorset, UK). Labrasol, Capryol 90 and Labrafil M2125 were kindly gifted from Gattefosse Company (Bracknell, UK).
Transcutol p
Manufactured by Merck Group
Sourced in United States, Germany
Transcutol P is a pharmaceutical excipient produced by Merck Group. It is a highly purified propylene glycol monoether that is used in the formulation of various pharmaceutical and cosmetic products.
Automatically generated - may contain errors
Lab products found in correlation
Tween 80, by Merck Group (11 mentions)
Tween 20, by Merck Group (4 mentions)
Isopropyl myristate, by Merck Group (3 mentions)
Propylene glycol, by Merck Group (3 mentions)
Oleic acid, by Merck Group (3 mentions)
Peg400, by Merck Group (2 mentions)
Cremophor el, by Merck Group (2 mentions)
Span 80, by Merck Group (2 mentions)
Span 20, by Merck Group (2 mentions)
Tween 40, by Merck Group (2 mentions)
Cremophor rh40, by Merck Group (2 mentions)
α linolenic acid, by Merck Group (1 mentions)
Butylated hydroxytoluene, by Merck Group (1 mentions)
Polyethylene glycol 400 peg 400, by Merck Group (1 mentions)
Labrafil, by Merck Group (1 mentions)
Isopropyl palmitate, by Merck Group (1 mentions)
Minispin, by Eppendorf (1 mentions)
Cmc na, by Merck Group (1 mentions)
Glycerine, by Merck Group (1 mentions)
Peg 400, by Daejung Chemicals (1 mentions)
13 protocols using transcutol p
1
Lipid Formulation Reagent Sourcing
2
Efinaconazole Topical Formulation Development
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Efinaconazole was received as a gratis sample kindly donated by Lupin, Pune, India. Butylated hydroxytoluene (BHT), disodium ethylenediaminetetraacetic acid (EDTA), isopropyl myristate, isopropyl palmitate, Labrafil®, Labrasol®, N-Methyl-2-pyrrolidone, polyethylene glycol 400 (PEG 400), polyvinylpyrrolidone K30 (PVP K30), propylene glycol, Transcutol® P, and Tween 80, were obtained commercially (Sigma Aldrich, St. Louis, MO, USA). Ethyl alcohol, isopropyl alcohol, acetonitrile, and potassium dihydrogen phosphate were obtained from Qualikems, New Delhi, India.
3
Solubility Screening of Flavonoids
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To select the appropriate surfactant and cosurfactant, the solubility of flavonoids was measured in Cremophor EL (polyoxyethylene [35] castor oil) and TWEEN® 80 (polyoxyethylene [20] sorbitan monooleate; Sigma-Aldrich Co., St Louis, MO, USA), surfactants, and in Transcutol® P (diethylene glycol monoethyl ether) and polyethylene glycol (PEG) 400 cosurfactants. Excess TFRA was added to 1 mL of each solvent at a temperature of 37°C±0.5°C, stirred with a magnetic bar at 300 rpm for 24 hours, and then centrifuged (MiniSpin®; Eppendorf, Hamburg, Germany) at 10,000 rpm for 10 minutes. The supernatant was diluted and assayed using HPLC.
4
Withania coagulans Fruit-based Formulation
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Withania coagulans fruit was purchased from the local market. Pregabalin and Carbopol 934 were generously gifted by Brookes Pharma (Pvt.) Ltd., Karachi and Saffron Pharmaceuticals (Pvt.) Ltd., Faisalabad, Pakistan, respectively. Frankincense oil was purchased from Co Natural™. Transcutol® P and Tween 80 were acquired from Gattefosse, France (Nanterre, France) and Sigma-Aldrich (St. Louis, MO, USA), respectively. Xylazine and Ketamine were used to anaesthetize the animals. All other chemicals and reagents used were of analytical grade. Distilled water was used during the whole study.
5
Bovine Lactoferrin-Fenofibrate Nanoemulsion
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Spray-dried bovine lactoferrin
powder (pinkish white, free-flowing, purity >95%, moisture <5%)
was procured from lactoferrin.Co, Australia. Fenofibrate IP (white
crystalline powder, assay: 99.6%, loss on drying: 0.19%) was generously
provided by Sun Pharma Laboratories Limited, India. SR Crodamol GTCC
(super-refined synthetic medium chain triglyceride, colorless, odorless
liquid, specific gravity: 0.95, viscosity: 25 mPass) was received
as a generous gift from Croda India Ltd., Mumbai. Tween 80 was procured
from Research-lab Fine Chem Industries, Mumbai. Edible grade sunflower
oil, soyabean oil, and castor oil are procured from local market.
Transcutol P was procured from Sigma-Aldrich, USA. All other reagents
used in this research were of chemical and analytical grade. Double
distilled water was collected from the distillation system of the
research lab.
powder (pinkish white, free-flowing, purity >95%, moisture <5%)
was procured from lactoferrin.Co, Australia. Fenofibrate IP (white
crystalline powder, assay: 99.6%, loss on drying: 0.19%) was generously
provided by Sun Pharma Laboratories Limited, India. SR Crodamol GTCC
(super-refined synthetic medium chain triglyceride, colorless, odorless
liquid, specific gravity: 0.95, viscosity: 25 mPass) was received
as a generous gift from Croda India Ltd., Mumbai. Tween 80 was procured
from Research-lab Fine Chem Industries, Mumbai. Edible grade sunflower
oil, soyabean oil, and castor oil are procured from local market.
Transcutol P was procured from Sigma-Aldrich, USA. All other reagents
used in this research were of chemical and analytical grade. Double
distilled water was collected from the distillation system of the
research lab.
6
Topical Formulation Development and Evaluation
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DIF was supplied by AK Scientific (US). Sunflower oil, lavender oil, sandalwood oil, eucalyptus oil and rosemary oil were obtained from Go Natural, Pakistan. Olive oil was acquired from Jiaxing, Sunlong Industrial and Trading Co. Ltd, China. Glycerine, propylene glycol, Tween 80, Tween 40, Tween 20, Span 20, Span 80, Transcutol-P and CMC-Na were purchased from Sigma-Aldrich, USA. Na-ALG, PEG 400 and propanol were purchased from Daejung, Korea. Analytical grade chemicals/reagents were used in the study.
7
Topical Ticagrelor Formulation Development
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Ticagrelor (TCG) was a
gift from CCL Pharmaceuticals (Lahore, Pakistan, Punjab). Clove oil,
silicon oil, lavender oil, olive oil, oleic acid, Tween-20 (polyoxyethylenesorbitan
monolaurate), triethanolamine (Sterolamide), Tween-80 (polyoxyethylenesorbitan
monooleate), Transcutol-P (diethylene glycol monoethyl), PEG-400 (polyethylene
glycol-400), and methanol were kindly provided by Sigma-Aldrich. Distilled
water was utilized throughout the course of the experiment.
gift from CCL Pharmaceuticals (Lahore, Pakistan, Punjab). Clove oil,
silicon oil, lavender oil, olive oil, oleic acid, Tween-20 (polyoxyethylenesorbitan
monolaurate), triethanolamine (Sterolamide), Tween-80 (polyoxyethylenesorbitan
monooleate), Transcutol-P (diethylene glycol monoethyl), PEG-400 (polyethylene
glycol-400), and methanol were kindly provided by Sigma-Aldrich. Distilled
water was utilized throughout the course of the experiment.
8
Triamcinolone Acetonide Formulation Development
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Triamcinolone acetonide (TA), linOleic acid, Span 85, tyloxapol, Tween 80, Cremophor RH40 (PEG-40 hydrogenated castor oil), propylene glycol (PG), Transcutol P (diethylene glycol ethyl ether), tetraglycol, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), cisplatin, and rhodamine B were purchased from Sigma-Aldrich (St. Louis, MO, USA). Capmul MCM (glyceryl caprylate/caprate) was obtained from Abitec Corporation (Columbus, OH, USA). Labrafil M1944 CS (oleoyl macrogol-6 glycerides) and Labrasol were purchased from Gattefossé (Saint-Priest, Cedex, France). Oleic acid, cotton oil, linseed oil, olive oil, castor oil, Tween 20, ethanol, and ether were provided by Samchun Chemical (Pyungtaek, South Korea). Glycerin, isopropanol, and polyethylene glycol 400 (PEG 400) were provided by Daejung Chemical (Siheung, South Korea). Poloxamer 407 (Kolliphor® P407) and poloxamer 188 (Kolliphor® P188) were purchased from BASF (Ludwigshafen, Germany). Phosphate-buffered saline (PBS), fetal bovine serum (FBS), antibiotics (penicillin/streptomycin), and Dulbecco’s modified Eagle’s medium (DMEM) were purchased from HyClone (Logan, UT, USA).
9
Erucin Extraction from Eruca Sativa
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Paclitaxel [gift sample from Kwality Pharmaceuticals (Amritsar, India)], Tween 80 was obtained from Merck, India. Transcutol P was acquired from Sigma Aldrich. Frankincense oil was purchased from Devinez (India). All other chemicals and reagents used were of analytical grade. Erucin, used in this study was isolated from the seeds of Eruca sativa according to our previously described method (Arora et al., 2016 (link)).
10
Formulation Optimization for Griseofulvin
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Isopropyl myristate, oleic acid, span20, transcutol-P and tween80 were purchased from Merck Chemical company (Germany). Diethylene glycol monoethyl ether (Transcutol P), Caprylocaproyl macrogoglycerides (Labrasol), pleurol oleic were kindly gifted by GATTEFOSSE Company (France), and griseofulvin powder was obtained from Darou Pakhsh company (IR Iran). The effect of variables on different responses was assessed by experimental design using Minitab 17. Ternary phase diagrams were plotted Sigma plot 12.
+ Expand
Isopropyl myristate, oleic acid, span20, transcutol-P and tween80 were purchased from Merck Chemical company (Germany). Diethylene glycol monoethyl ether (Transcutol P), Caprylocaproyl macrogoglycerides (Labrasol), pleurol oleic were kindly gifted by GATTEFOSSE Company (France), and griseofulvin powder was obtained from Darou Pakhsh company (IR Iran). The effect of variables on different responses was assessed by experimental design using Minitab 17. Ternary phase diagrams were plotted Sigma plot 12.
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