Neratinib hki 272

Manufactured by Selleck Chemicals

Sourced in United States

Neratinib (HKI-272) is a chemical compound used in laboratory research. It functions as a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR) family of proteins.

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Lab products found in correlation

Lapatinib gw572016, by Selleck Chemicals (1 mentions) Filipin, by Merck Group (1 mentions) Rabbit anti phospho akt ser473 antibody, by Cell Signaling Technology (1 mentions) Lovastatin, by Meilun (1 mentions)

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Neratinib (34 citations)

3 protocols using neratinib hki 272

HER2 Inhibitor and DVL2 Loss

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Neratinib (HKI-272), a clinically approved highly selective HER2 and epidermal growth factor receptor (EGFR) inhibitor, was purchased commercially (Selleckchem). Time dependent dose response studies were performed in both cancer cell lines (data not shown) to select the final dose of 1 nM. NTC and shDVL2 stable cell lines were treated with and without 1 nM for 24 h to investigate the combined effect of DVL2 loss of function and HER2 inhibition in two different HER2+ breast cancer cell lines. RNA and protein samples were collected, and cell cycle analyses were performed.

Rasha F., Boligala G.P., Yang M.V., Martinez-Marin D., Castro-Piedras I., Furr K., Snitman A., Khan S.Y., Brandi L., Castro M., Khan H., Jahan N., Almodovar S., Melkus M.W., Pruitt K, & Layeequr Rahman R. (2023). Dishevelled 2 regulates cancer cell proliferation and T cell mediated immunity in HER2-positive breast cancer. BMC Cancer, 23, 172.

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Synthesis of Trans-(±)-kusunokinin and Neratinib

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Trans-(±)-kusunokinin was synthesized following the procedure reported in our previous publication [19 (link)]. Neratinib (HKI-272) was obtained from Selleck Chemicals (CAS No: S2150, Houston, TX, USA).

Rattanaburee T., Tanawattanasuntorn T., Thongpanchang T., Tipmanee V, & Graidist P. (2021). Trans-(−)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines?. Molecules, 26(15), 4537.

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Immunoblotting Analysis of ErbB2 Signaling

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Mouse anti-ErbB2 (A-2), anti-ErbB2 (9G6), anti-Vinculin antibodies were purchased from Santa Cruz Biotechnology (CA, USA). Rabbit anti-PARP antibody was purchased from Proteintech (Wuhan, China). Rabbit anti-phospho-Akt (Ser473) antibody was purchased from Cell Signaling Technology. Secondary goat anti-mouse and anti-rabbit, donkey anti-goat antibodies were obtained from LICOR. Neratinib (HKI-272) and lapatinib (GW572016) were purchased from Selleck. Oleic acid (OA) and lovastatin were obtained from MeilunBio (Dalian, China). Filipin was obtained from Sigma.

Zhang J., Li Q., Wu Y., Wang D., Xu L., Zhang Y., Wang S., Wang T., Liu F., Zaky M.Y., Hou S., Liu S., Zou K., Lei H., Zou L., Zhang Y, & Liu H. (2019). Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer. Cell Communication and Signaling : CCS, 17, 15.

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