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Timp 3 ab39184

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TIMP-3 (ab39184) is a recombinant protein that corresponds to the full-length human Tissue Inhibitor of Metalloproteinases 3 (TIMP-3). TIMP-3 is a member of the TIMP family and acts as an inhibitor of matrix metalloproteinases.

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Lab products found in correlation

Ab124824, by Abcam (1 mentions) Ab25117, by Abcam (1 mentions) Ab92486, by Abcam (1 mentions) P65 8242, by Cell Signaling Technology (1 mentions)

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Ab39184 (18 citations)

2 protocols using timp 3 ab39184

1

Osteoarthritis Treatment Protocol

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AMD3100 (ab120718, Purity: > 99%), LY303511 (ab145193) and primary antibodies for CXCL12 (ab25117), CXCR4 (ab124824), aggrecan (ab36861) ADAMTS-5 (ab41037), Smad3(ab52903), TIMP-3 (ab39184) and TGF-β1 (ab92486) were purchased from Abcam (Cambridge, UK), p-Akt (ab38449), p-Smad3 (ab122028) were purchased from Optomics (Hermiston, OR, USA).CXCL12a and CXCL12b ELISA kits were purchased from Tsz Biosciences (Boston, MA, USA). Alzet osmotic mini-pumps (2006) were purchased from DURECT Corporation (Cupertino, CA, USA). Recombinant rat CXCL12a, IL-1 and other reagents were purchased from Beyotime (Shanghai, China).
Lu W., He Z., Shi J., Wang Z., Wu W., Liu J., Kang H., Li F, & Liang S. (2020). AMD3100 Attenuates Post-Traumatic Osteoarthritis by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3-Kinase/Akt Pathway. Frontiers in Pharmacology, 10, 1554.
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2

Protein Expression Analysis by Western Blot

Cited 1 time
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Western blot analysis was done as described previously50 (link). Antibodies were obtained from several providers. Cleaved caspase-3 (9661), Cleaved caspase-9 (7237), Caspase-3 (9662), Caspase-9 (9508) and p65 (8242) were from Cell Signaling (Danvers, MA, USA), β-actin (sc-130300), PCNA (sc-25280), Bax (sc-7480), p50 (sc-114), MMP-2 (sc-13595), MMP-3 (sc-6839), MMP-13 (sc-12363), normal mouse IgG (sc-2025) and MMP-9 (sc-127590 were purchased from Santacruz (Dallas, TX, USA) and IL-32 (513601) was obtained from BioLegend, (San Diego, CA USA). TIMP3 (ab39184) and DNMT1 (ab19905) were obtained from Abcam (Cambridge, MA, USA).
Yun J., Park M.H., Son D.J., Nam K.T., Moon D.B., Ju J.H., Hwang O.K., Choi J.S., Kim T.H., Jung Y.S., Hwang D.Y., Han S.B., Yoon D.Y, & Hong J.T. (2018). IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation. Cell Death & Disease, 9(3), 306.
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