Inveon dedicated pet dpet system

We conducted PET-CT imaging with the Siemens Inveon Dedicated PET (dPET) System and Inveon Multimodality (MM) System (CT-SPECT) (Siemens INVEON PET/CT, Germany) at the Peking Union Medical College Hospital. We injected 500 mCi 18F-fluorodeoxyglucose (18F-FDG) into the tail vein of the mice. The mice were fixed on the instrument during the measurement. After 60 min, we analyzed the images on the Inveon Acquisition Workplace. The absorption and utilization of glucose in different parts and organs were indicated by color changes in different parts of the mice.

Positron emission-computed tomographic (PET-CT) imaging was achieved with the Siemens Inveon Dedicated PET (dPET) System and Inveon Multimodality (MM) System (CT-SPECT) (Siemens Preclinical Solutions, Knoxville, TN, USA). The detailed procedure was described previously^{35 (link)}.

Siemens Inveon Dedicated PET (dPET) System and Inveon Multimodality (MM) System (CT/SPECT) (Siemens Preclinical Solutions) was used to detect PET-CT imaging at Chinese Academy of Medical Sciences. According to the previously studies (Liu et al., 2013 (link); Yuan et al., 2016 (link)), mice were allowed to fast overnight and were lightly anesthetized with isoflurane, and then followed by a tail vein injection of 18F-FDG (500 mCi). Sixty minutes after the injection of the radiotracer, the mice were subjected to PET/CT analysis. A 10 min CT X-ray for attenuation correction was scanned before PET-CT scan. Static PET-CT scans were acquired for 10 min, and images were reconstructed by an OSEM3D algorithm followed by Maximization/Maximum a Posteriori (MAP) or Fast MAP provided by Inveon Acquisition Workplace (IAW) software. The 3D regions of interest (ROIs) were drawn over the guided CT images, and the tracer uptake was measured using Inveon Research Workplace (IRW) (Siemens) software. Individual quantification of the 18F-FDG uptake in each of the ROI was calculated. The data for the accumulation of 18F-FDG on micro-PET images were expressed as the standard uptake values (SUVs), which were determined by dividing the relevant ROI concentration by the ratio of the injected activity to the bodyweight.