Farnesyl diphosphate

Manufactured by Echelon Biosciences

Farnesyl diphosphate is a key intermediate in the mevalonate pathway, which is involved in the biosynthesis of various important lipids, including cholesterol, steroid hormones, and dolichols. It serves as a substrate for the enzyme farnesyltransferase, which catalyzes the addition of a farnesyl group to target proteins, a process essential for their proper localization and function.

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Lab products found in correlation

Propidium iodide, by Merck Group (1 mentions) Zaragozic acid, by Merck Group (1 mentions) Pitavastatin, by Merck Group (1 mentions) Farnesol, by Echelon Biosciences (1 mentions) Geranylgeraniol, by Merck Group (1 mentions)

2 protocols using farnesyl diphosphate

Inhibition of Mast Cell Signaling

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Cytokines were purchased from Biolegend. Mouse IgE for in vivo studies was generously provided by Dr. Daniel Conrad (VCU). Purified mouse IgE (clone C38-2, κ isotype) was purchased from BD Biosciences (San Diego, CA). Antibodies recognizing mouse CD49b, CD63, TNF, IL-4 and IL-6 were from Biolegend. Antibodies against c-Kit, FcεRI, Syk, IL-13, MIP-1α (CCL-3), MCP-1 (CCL-2), phosphoserine-473-AKT, and phosphothreonine 202/phosphotyrosine 204-ERK-1/2 were from Cell Signaling Technology (Danvers, MA). Propidium Iodide and dinitophenyl-coupled human serum albumin (DNP-HSA) were from Sigma-Aldrich (St. Louis, MO). Zaragozic acid and all statin drugs except Pitavastatin were from Sigma-Aldrich. Pitavastatin (ab141958) was from Abcam (Cambridge, MA). Farnesylation transferase inhibitor III (FPTIII) and geranylgeranyl transferase inhibitor-286 (GGTI-286) were from Calbiochem (Darmstadt, Germany). Farnesyl diphosphate and geranyl geranyl diphosphate were from Echelon (Salt Lake city, UT).

Kolawole E.M., McLeod J.J., Ndaw V., Abebayehu D., Barnstein B.O., Faber T., Spence A.J., Taruselli M., Paranjape A., Haque T.T., Qayum A.A., Wijesinghe D.S., Sturgill J.L., Chalfant C.E., Straus D.B., Oskeritzian C.A, & Ryan J.J. (2016). Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. Journal of immunology (Baltimore, Md. : 1950), 196(4), 1461-1470.

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Isopentenyl Diphosphate Biosynthesis

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Isopentenyl diphosphate (IPP), dimetylallyl diphosphate (DMAPP), farnesyl diphosphate (FPP), geranyl diphosphate (GPP), farnesol (FOL) and geraniol (GOL) were obtained from Echelon Biosciences (Salt lake City, UT). Geranylgeraniol (GGO) was obtained from Sigma (St. Louis, MO).

Rivera-Perez C., Nyati P, & Noriega F.G. (2015). A corpora allata farnesyl diphosphate synthase in mosquitoes displaying a metal ion dependent substrate specificity. Insect biochemistry and molecular biology, 64, 44-50.

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