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34 protocols using lightspeed plus

1

CT Contrast of IL@ZrO2 Nanoparticles

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CT imaging in vitro was performed using a GE Lightspeed Plus. Isometric IL@ZrO2 dispersed in PBS solutions with a wide concentration range (1.25, 0.65, 0.30, 0.15, 0 mg mL–1) was added into a PE tube and then scanned with the GE Lightspeed Plus. The group containing pure PBS solution was designed as the control group. The CT value of each group was recorded to evaluate the CT contrast properties of the IL@ZrO2 nanoparticles.
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2

PET Imaging of [18F]-FLT Uptake

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Patients received an intravenous injection of 185 MBq of [18F]-FLT and then rested for 60 minutes prior to imaging. Imaging was performed with an integrated PET/CT scanner (Discovery LS, GE Healthcare), consisting of a combined full-ring PET scanner (Advance NXi) and an eight-section helical CT scanner (Light Speed Plus). The CT was performed with 140 kV, 80 mA, a tube-rotation time of 0.8 seconds per rotation, a pitch of 1.675 mm/rotation, with CT slice thickness of 3.75 mm at intervals of 3.27 mm and a matrix of 512 by 512 pixels. The CT data were reconstructed with a slice thickness of 5.0 mm and a matrix of 512 by 512 pixels. Patients were allowed normal, quiet breathing during imaging. PET data sets were reconstructed iteratively using the ordered subsets expectation maximization (OSEM) algorithm with segmented attenuation correction (two iterations). PET images were up-interpolated by vendor-provided software to match the CT matrix for image fusion. Independent as well as co-registered images were displayed by using a vendor provided workstation (Xeleris; GE Medical Systems). Images were evaluated by a qualified nuclear medicine physician (RCW).
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3

PET/CT Imaging and Nodular FDG Uptake

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FDG PET/CT images were acquired using a PET/CT device (Discovery LS; GE Healthcare, Milwaukee, WI, USA), which consisted of a PET scanner (Advance NXi; GE Healthcare) and an eight-slice CT scanner (Light-Speed Plus; GE Healthcare). A nuclear medicine physician who was unaware of clinicopathologic information interpreted the PET images. ROIs were drawn over the most intense area of FDG uptake for semi-quantitative analysis. When it was not possible to evaluate nodular FDG uptake, an ROI was drawn in a presumed nodular location considering CT component images of PET/CT. FDG uptake within the ROIs was calculated as SUVmax.
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4

Quantitative Assessment of Tibial Bone Density

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The bone mineral density (BMD) of all the collected tibiae was analyzed using quantitative computed tomography (QCT) at the college of Veterinary Medicine, Konkuk University (Korea, Seoul). Three positions of each tibia including neck (section of the mastoid arthrodesis), 1/3 of the proximal portion, and 2/3 of the distal portion were scanned using a CT scanner (LightSpeed Plus, GE Healthcare, Amersham, UK). The scanning conditions were as follows: 120 kV and 200 mA, slice thickness 1.25 mm, slice interval 1.25 mm, pitch 1.5:1, rotation time 0.6 s, and scanning speed 7.5 mm/rotation. The scanned images were archived in DICOM (Digital Imaging and COmmunications in Medicine) format and were evaluated by using a 3D slicer software (Version 4.6.2 r25516, National Alliance for Medical Image Computing). The Hounsfield unit (HU) values of each standard point of the three positions in a tibia were taken and the trend equation was obtained using a single-layer computerized photograph through QCT calibration phantom (QRM-BDC/3, QRM GmbH, Moehrendorf, Germany). The HU values obtained from the QCT scans were used to calculate BMD (mg/cm3).
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5

Contrast-Enhanced CT Imaging Protocol for Tumor Evaluation

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All patients underwent contrast enhanced CT examination of their chest, abdomen and pelvis (GE Lightspeed Plus or GE Lightspeed VCT) following injection of 100 ml of an iodinated contrast agent (Omnipaque 300, Iohexol, GE Healthcare, Princeton, NJ, USA) at a rate of 3 ml/s via an automated injector.
Images of the thorax were analyzed in arterial phase (25-s delay) and images of the abdomen and pelvis were analyzed in portal venous phase (70-s delay) with the following acquisition parameters: 120 kV; auto mA and Smart mA (angular and z-axis modulation); pitch 0.75:1 and 0.9:1; 20 mm collimation, 5 mm slice thickness and 40 mm collimation reconstructed; scan field of view (FOV) 50 cm and display FOV adjusted to patient size; matrix: 512x512 (pixel spacing: 0.933 mm). Region of interest (ROI) was drawn by a radiologist with 6 years of experience of reporting abdominal CT who was blinded to the clinical outcome. Each ROI was drawn on the slice through the largest diameter of the tumor site.
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6

Fluoroscopic Liver Embolization Imaging

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Fluoroscopic images for angiography were acquired using a portable C-arm unit. Computed tomography data were acquired on a 4-slice Lightspeed Plus scanner (General Electric Medical Systems, Milwaukee, WI, USA) at 120 kVp with a slice thickness of 5 mm. DICOM images were then post-processed using Osirix MD 8.5.1 (Pixmeo, Geneva, Switzerland). Reformats were produced in various projections with sculpting of extraneous tissue performed to disclose the liver. This was then windowed and leveled using a pseudo-color scheme to depict the distribution of embolic material in the liver.
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7

CT Imaging Protocol for Respiratory Studies

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All patients were placed in the supine position and scanning was performed at end-inspiration. One unit (HiSpeed Advantage; GE Medical Systems, Milwaukee, Wisconsin, USA) was used in eight patients with the following parameters: section thickness = 1 mm; gap = 10 mm; scanning time per section = 1 or 2 s; 120 kV; and 240 mA. Another unit (Lightspeed plus; GE Medical Systems) was used in three patients with the following parameters: section thickness = 1.3 mm; gap = 10 mm; scanning time per section = 1 s; 120 kV; and 264 mA. A third unit (Philips Ingenuity; Philips, Netherlands) was used in three patients with the following parameters: section thickness = 1.0 mm; gap = 10 mm; scanning time per section = 1 s; 120 kV; and 269 mA. The images were photographed at lung (window width = 1000–  1600 HU; window level = – 600 HU) and mediastinal (window width = 350 HU; window level = 35– 40 HU) settings.
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8

Chest CT Imaging Protocol for COVID-19

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LightSpeed Plus (GE, Medical System, Milwaukee, WI) and UCT 780 (United Imaging, Shanghai, China) were employed for scanning chest CT images with a tube voltage of 120 kV combined with automatic tube current modulation (100–400 mA). Images were reconstructed with a slice thickness of 1.25 mm and an interval of 1.25 mm, respectively. All patients underwent initial CT 3 days after the onset of symptoms. The interval time from initial to follow-up examination was 5 days.
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9

Framingham Heart Study Cross-Sectional Analysis

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Subjects for a cross-sectional analysis were selected from the Framingham Heart Study Multidetector CT Study cohort(19 (link)) in a sex- and age-stratified manner, with 25 men and 25 women included in each of five age groups (40–49, 50–59, 60–69, 70–79, 80+). The 125 men were the same subjects included in our prior study,(20 (link)) and the 125 women were selected in a similar manner. Subjects were sampled from cohort participants who had previously collected computed tomography (CT) scans of the chest and abdomen including approximately levels T4 to L4. Scans were collected on an eight-detector helical CT scanner (Lightspeed Plus, General Electric, Milwaukee, WI, USA; scan settings: 120 kVP, 320 mAs, in-plane pixel size 0.68 × 0.68 mm, slice thickness 2.5 mm). Subjects were scanned with a three-chamber hydroxyapatite phantom (Image Analysis, Inc., Lexington, KY, USA). Use of these previously collected, de-identified data was approved by the Institutional Review Board of Beth Israel Deaconess Medical Center.
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10

Multi-Center CT Imaging Protocols

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As shown in Figure 2, 62 patients from Harbin (Heilongjiang Province) were scanned using a 256-slice CT scanner (Philips Healthcare, Cleveland, OH, US), 30 patients from Shuangyashan (Heilongjiang Province) were scanned with a Somatom Balance CT scanner (Siemens Healthcare, Forchheim, Germany), 27 patients from the Uygur autonomous region (Xinjiang Province) were examined with LightSpeed Plus (GE, Medical System, Milwaukee, USA), 21 patients from Chengdu (Sichuan Province) were examined with a 128-slice dual-source CT (Siemens Healthcare, Forchheim, Germany), and 10 patients from Xinxiang (Henan Province) were imaged with a Somatom definition 64 slice CT scanner (Siemens Healthcare, Forchheim, Germany). Twenty-five patients from Ankang (Shaanxi Province) were imaged with 16 slice, Optimal CT 520 (GE, Medical System, Milwaukee, USA), 34 patients from Langfang (Hebei Province) were imaged with BrightSpeed (GE, Medical System, Milwaukee, USA), and 12 patients from Tianjin (Hebei Province) were imaged with Aquilion 16 slice CT scanner (TOSHIBA, Medical Systems, Tokyo, Japan). All these CT images were reconstructed into a slice thickness of 1.0–5.0 mm. Scan were performed in the supine position during end-inspiration.
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