The study was comprised of 3 periods: acclimation (days −13 to −7), baseline (days −6 to 0), and treatment (days 1‐28). During the acclimation period, dogs were administered fenbendazole (50 mg/kg q24h, PO, days −13 to −9) and ivermectin (200 μg/kg SC once, day −13). As part of routine colony prophylaxis, dogs also received imidacloprid and moxidectin (Advantage Multi for dogs; Bayer HealthCare, LLC, Shawnee Mission, Kansas), dosed per manufacturer's instructions.
All dogs received water ad libitum and were fed a commercial kibble once daily in quantities sufficient to maintain ideal body condition. An observer not associated with the study and blinded to the treatment groups, medications, and all study‐related findings collected observations twice daily throughout the study (days −13 to 28). Attitude was characterized as normal or abnormal. Food intake was recorded to the nearest quartile consumed (0%, 25%, 50%, or 100%). The presence of vomiting, melena, or hematochezia was recorded, and feces were scored using a standard scale.15
All dogs received water ad libitum and were fed a commercial kibble once daily in quantities sufficient to maintain ideal body condition. An observer not associated with the study and blinded to the treatment groups, medications, and all study‐related findings collected observations twice daily throughout the study (days −13 to 28). Attitude was characterized as normal or abnormal. Food intake was recorded to the nearest quartile consumed (0%, 25%, 50%, or 100%). The presence of vomiting, melena, or hematochezia was recorded, and feces were scored using a standard scale.