Moclobemide

Manufactured by Selleck Chemicals

Sourced in United States

Moclobemide is a laboratory equipment product designed for use in scientific research and analysis. It is a reversible inhibitor of monoamine oxidase A (RIMA) enzyme. The core function of Moclobemide is to inhibit the breakdown of neurotransmitters, such as serotonin and norepinephrine, in the brain and other tissues.

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Lab products found in correlation

2 protocols using moclobemide

Harmine-Induced Adipocyte Regulation

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Differentiated adipocytes were treated in DMEM plus 10% FBS, with addition of 1 μM harmine or DMSO (as vehicle control) in the presence or absence of 1 μM inhibitors for 24 h. After that, the cells were harvested for real time qPCR analysis. TBB (sc-202830) was purchased from Santa Cruz Biotechnology; moclobemide, ZD6244, SB202190, LY294002 and GW9662 were from Selleck.

Nie T., Hui X., Mao L., Nie B., Li K., Sun W., Gao X., Tang X., Xu Y., Jiang B., Tu Z., Li P., Ding K., Han W., Zhang S., Xu A., Ding S., Liu P., Patterson A., Cooper G, & Wu D. (2016). Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis. Scientific Reports, 6, 36382.

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Pharmacological Screening of Cellular Modulators

Cited 1 time

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Acetylcysteine, astaxanthin, epigallocatechin gallate, harmine, LY294002, metformin, moclobemide, phenformin, piperlongumine, rapamycin, resveratrol, sirtinol, spermidine, and tetrahydrocurcumin were purchased from Selleck Chemicals (Houston, TX, USA). rapamycin was purchased from LC Laboratories (Woburn, MA, USA); dihydroethidium, hydroxyurea, and phenformin hydrochloride were obtained from Sigma (St. Louis, MO, USA); and leptomycin B (LMB) was purchased from Alomone Labs (Jerusalem, Israel). AnnH75 was developed and synthesized in the Bracher Lab (Ludwig-Maximilians University, Munich, Germany) (16 (link)).

Jimenez L., Silva A., Calissi G., Grenho I., Monteiro R., Mayoral-Varo V., Blanco-Aparicio C., Pastor J., Bustos V., Bracher F., Megías D., Ferreira B.I, & Link W. (2021). Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 77(8), 1485-1493.

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