Uk 356618

Unless otherwise stated, all chemicals were purchased from Sigma (St. Louis, MO). Cell culture plastics were obtained from Nunc (Roskilde, Denmark). SB202190 (p38 MAPK inhibitor) and MG-132 (NF-κB inhibitor) were purchased from Cell Signaling Technology (Danvers, MA), SB431542 (Smad inhibitor) from Abcam (Cambridge, UK) and GN-25 (Snail inhibitor) from Cayman Chemical (Ann Arbor, MI). Neutralizing antibodies against CCL2, CXCL1, CXCL8, ICAM-1, IL-6, PAI-1, TGF-β1 and VEGF were from R&D Systems (Abingdon, UK). The antibody against TSP-1 was from Abcam (Cambridge, UK; anti-TSP-1). UK-356618 and BC 11 hydrobromide, selective inhibitors of MMP-3 and uPA, respectively, were obtained from R&D Systems. The GRGDSP peptide that blocks fibronectin from binding to its receptors was purchased from Sigma.

Unless otherwise stated, all chemicals and plastics were from Sigma (St. Louis, MO, USA). Recombinant proteins were from R&D Systems (Abingdon, UK). The neutralizing antibodies, UK-356618 and BC 11 hydrobromide were from R&D Systems (the antibody against TSP-1 was from Abcam (Cambridge, UK)). GRGDSP was from Sigma and SB202190 from Cell Signaling Technology (Danvers, MA, USA).