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Klucel exf

Manufactured by Ashland
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Sourced in United States

Klucel EXF is a high-viscosity hydroxypropylcellulose (HPC) product manufactured by Ashland. It is a water-soluble, nonionic cellulose ether that functions as a thickener, binder, and stabilizer in various formulations.

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Lab products found in correlation

Warfarin sodium, by Merck Group (1 mentions) Phenacetin, by Tokyo Chemical Industry (1 mentions) Soluplus, by BASF (1 mentions) Kollidon 12 pf, by BASF (1 mentions) Benecel k15m, by Ashland (1 mentions) Avicel ph 101, by FMC Biopolymer (1 mentions) Qicpic, by Sympatec (1 mentions)

3 protocols using klucel exf

1

Warfarin sodium polymer formulation

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Warfarin sodium was purchased from Sigma-Aldrich (USA), polyvinyl alcohol (PVA) (Mowiol 4-98, MW ~27,000) was purchased from Sigma-Aldrich (Germany), hydroxypropyl cellulose (HPC) (Klucel EXF) was kindly provided by Ashland (Switzerland) and ethanol (Etax A, min. 94.0 w-%) was purchased from Altia (Finland). The water that was used was purified by Millipore SA-67120 from Millipore (France) and all reagents were of analytical grade and used without further purification.
Sjöholm E, & Sandler N. (2019). Additive manufacturing of personalized orodispersible warfarin films. International journal of pharmaceutics, 564.
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2

Aripiprazole Formulation Development and Characterization

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Aripiprazole (melting point at 137–142°C) was obtained from Nexconn Pharmatechs Ltd. (Tseung Kwan O, Hong Kong). Phenacetin (internal standard, IS, Figure S1B) was purchased from Tokyo Chemical Industry Co., Ltd (Tokyo, Japan). Acidifiers (adipic acid, citric acid, fumaric acid, malic acid, maleic acid, stearic acid, succinic acid, and tartaric acid) were purchased from Spectrum Quality Products, Inc. (Gardena, CA, USA). Kollidon® 12 PF and Soluplus® were generously supplied by BASF Corporation (Florham Park, NJ, USA). AquaSolve™, HPMCAS-LG, Klucel™ EXF, Benecel™ E15, Benecel™ K15M, and Natrosol™ 250L were gifted by Ashland, Inc. (Lexington, KY, USA). All other chemicals used were reagent grade and were used without further purification.
McFall H., Sarabu S., Shankar V., Bandari S., Murthy S.N., Kolter K., Langley N., Kim D.W, & Repka M.A. (2018). Formulation of aripiprazole-loaded pH-modulated solid dispersions via hot-melt extrusion technology: In vitro and In vivo studies. International journal of pharmaceutics, 554, 302-311.
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3

Granulation of Lactose-Cellulose Formulation

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For granulation experiments a formulation consisting of 75% alpha lactose monohydrate (316/FAST-FLO®, Foremost Farms, USA), 20% Microcrystalline Cellulose (Avicel PH101, FMC BioPolymer, Ireland) and 5% Hydroxypropyl Cellulose (Klucel EXF, Ashland Inc, USA) was used. The formulation was blended in a Pascal lab mixer for 25 minutes to ensure homogenous mixing. Median particle size was determined to be ~125 μm through image size analysis (Sympatec QICPIC).
Chan Seem T., Rowson N.A., Gabbott I., de Matas M., Reynolds G.K, & Ingram A. (2016). Asymmetric distribution in twin screw granulation. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 106.
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