Verapamil

Manufactured by Abbott

Sourced in United States

Verapamil is a pharmaceutical compound used in the production of medical laboratory equipment. It functions as a calcium channel blocker, helping to regulate the flow of calcium ions across cell membranes. This property can be utilized in various laboratory applications, such as the study of cellular processes and the development of diagnostic or therapeutic tools. The specific details of Verapamil's intended use and applications are not included in this factual description.

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Lab products found in correlation

Phenylephrine, by Abbott (2 mentions) Phosphate buffer saline (pbs), by Thermo Fisher Scientific (1 mentions) Cell cycle determination kit, by Cayman Chemical (1 mentions) Acridine orange, by Thermo Fisher Scientific (1 mentions) Trypan blue powder, by Merck Group (1 mentions) Trypsin edta 0.05, by Thermo Fisher Scientific (1 mentions) Vanadate, by Merck Group (1 mentions) Vinblastine, by Merck Group (1 mentions) Doxorubicin, by Merck Group (1 mentions) Ponatinib, by Selleck Chemicals (1 mentions) Vincristine, by Merck Group (1 mentions) Bisindolylmaleimide 1 bim 1, by Cayman Chemical (1 mentions) Calcein am, by Thermo Fisher Scientific (1 mentions) Pd173074, by Selleck Chemicals (1 mentions) Nintedanib, by Selleck Chemicals (1 mentions) Azd4547, by Selleck Chemicals (1 mentions) Elacridar, by Merck Group (1 mentions)

4 protocols using verapamil

Cardiac Injury Biomarker Evaluation

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DOX, DIL and Trypan blue powder were purchased from Sigma Aldrich Co. (Saint Louis, Missouri, USA) while Verapamil was purchased from Abbott. Fetal bovine serum (FBS), Dulbecco’s Modified Eagle Medium (DMEM), Trypsin–EDTA (0.05%) and phosphate buffer saline (PBS, pH 7.4) were purchased from Thermo Fisher Scientific Inc (USA). Acridine orange (AO) (Molecular Probes, Eugene, OR, cat. no. A1301) and Giemsa stain (GS-10), rhodamine 123 (R8004 SIGMA) have been also supplied. The cell cycle determination kit was purchased from Cayman Chemical Company (USA). Animal kits include Rat CK-MB (Catalog No: E-EL-R1327 (USA)), MDA (Catalog No: E-EL-0060 (USA)), TAC (Catalogue No. 201-11-1187 (USA)) and GPx (Catalog No: CAT. No. GP 2524 (Biodiagnostic, Dokki, Egypt).

Al-malky H.S., Osman A.M., Damanhouri Z.A., Alkreathy H.M., Al Aama J.Y., Ramadan W.S., Al Qahtani A.A, & Al Mahdi H.B. (2019). Modulation of doxorubicin-induced expression of the multidrug resistance gene in breast cancer cells by diltiazem and protection against cardiotoxicity in experimental animals. Cancer Cell International, 19, 191.

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Phenylephrine-Induced Arrhythmia in Mice

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Phenylephrine 1mg/g(West-Ward Pharmaceutical, Eatontown, NJ, USA) or saline was injected IP to 3-month old mice following 10 minutes of recording at rest. These young animals do not have arrhythmia under resting conditions. An ECG recording was initiated 5 min after the injection and continued for another 10 minutes. On the next day mice were pretreated by IP verapamil (2.5 mg/g, Abbott, IL, USA) prior to Phenylephrine.

Kurtzwald-Josefson E., Hochhauser E., Bogachenko K., Harun-Khun S., Katz G., Aravot D., Seidman J.G., Seidman C.E., M.i.c.h.a.e.l.E.l.d.a.r., Shainberg A, & Arad M. (2014). Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice. Heart rhythm : the official journal of the Heart Rhythm Society, 11(8), 1471-1479.

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Comprehensive Drug Screening Protocol

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Nintedanib, ponatinib, AZD4547, PD173074 and QNZ were purchased from Selleckchem (Munich, Germany), bisindolylmaleimide I (BIMI) from Cayman Chemical (Michigan, USA), FGF2 from Eubio (Peprotech, Rocky Hill, USA), verapamil from Abbott (Illinois, USA), Calcein AM from eBioscience (San Diego, USA), vanadate, elacridar, vincristine, vinblastine, doxorubicin from Sigma. Tezosentan was obtained from Actelion Pharm, Allschwil, Switzerland.

Englinger B., Lötsch D., Pirker C., Mohr T., van Schoonhoven S., Boidol B., Lardeau C.H., Spitzwieser M., Szabó P., Heffeter P., Lang I., Cichna-Markl M., Grasl-Kraupp B., Marian B., Grusch M., Kubicek S., Szakács G, & Berger W. (2016). Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression. Oncotarget, 7(31), 50161-50179.

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Biochemical Analysis of Cardiac Biomarkers

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Methanol was purchased from Lahore Laboratory Chemicals, Lahore, PB, Pakistan. Verapamil and phenylephrine were purchased from Abbott Laboratories, KPK, Pakistan (PVT) Ltd. Adrenaline was purchased from Ameer Pharmaceuticals, Lahore, PB, Pakistan. LDH, troponin, CK-MB and ALT, ALP, CRP, AST kits were obtained from Pakistan Scientific traders, Lahore, PB, Pakistan. All other chemicals/reagents and solutions utilized in the experiments were of analytical grade.

Khan I.A., Hussain M., Syed S.K., Saadullah M., Alqahtani A.M., Alqahtani T., Aldahish A.A., Asiri S, & Zeng L.H. (2021). Pharmacological Justification for the Medicinal Use of Plumeria rubra Linn. in Cardiovascular Disorders. Molecules, 27(1), 251.

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