Pomc cre male mice

Manufactured by Jackson ImmunoResearch

POMC-Cre(+/−) male mice are genetically modified mice that express the Cre recombinase enzyme under the control of the proopiomelanocortin (POMC) gene promoter. The Cre enzyme can be used to induce targeted gene modifications in cells that express POMC.

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Lab products found in correlation

Wild type c57bl 6j male mice, by Jackson ImmunoResearch (2 mentions) R26 hm4di mcitrine, by Jackson ImmunoResearch (1 mentions)

2 protocols using pomc cre male mice

Entorhinal Cortex Contributions to Social Cognition

Cited 2 times

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All animal procedures were performed in accordance with the regulations of the Columbia University IACUC. 8- to 12-week-old male mice were used for most experiments. Male mice were used exclusively in this study, as there are significant differences in sociability and social recognition between male and female mice (Karlsson et al., 2015 (link); Krueger-Burg et al., 2016 (link)) that would complicate the present analyses. Future work will be required to study entorhinal cortical contributions to social cognition in females. The mice were group housed and maintained in a temperature- and humidity-controlled room on a 12:12 h light/dark cycle. All animals were provided with food and water ad libitum. All tests were conducted during the light cycle. Experiments were scored by an individual blind to the genotype and experimental design.
Wild-type C57BL/6J male mice (JAX Stock No: 000664) were obtained from the Jackson Laboratory. POMC-Cre(+/−) male mice (JAX Stock No: 010714) were obtained from Jackson Laboratory and were bred with R26-hM4Di/mCitrine female homozygous (JAX Stock No: 026219). Amigo-2 Cre male mice were obtained from Jackson Laboratory (JAX Stock No: 030215).

Lopez-Rojas J., de Solis C.A., Leroy F., Kandel E.R, & Siegelbaum S.A. (2022). A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory. Neuron, 110(9), 1559-1572.e4.

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Mouse Behavioral Study Procedures

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Experimental models. All animal procedures were performed in accordance with the regulations of the Columbia University IACUC. 8-to 12-week-old male mice were used for most experiments. The mice were group housed and maintained in a temperature-and humidity-controlled room on a 12:12 h light/dark cycle. All animals were provided with food and water ad libitum. All tests were conducted during the light cycle.
Wild-type C57BL/6J male mice were obtained from the Jackson Laboratory. POMC-Cre(+/-) male mice were obtained from Jackson Laboratory and were bred with R26-hM4Di/mCitrine female homozygous.

Lopez‐Rojas J., Solis C.A.d., Leroy F., Kandel E.R., & Siegelbaum S.A. (2021). A direct lateral entorhinal cortex to hippocampal CA2 circuit conveys social information required for social memory.

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