Succinic anhydride

Manufactured by Adamas

Sourced in China, Saudi Arabia

Succinic anhydride is a cyclic organic compound with the chemical formula C4H4O3. It is a colorless, crystalline solid that is commonly used as a reagent in organic synthesis and the production of various chemicals and materials.

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Lab products found in correlation

2 protocols using succinic anhydride

Succinic anhydride-conjugated PEI for P-glycoprotein silencing

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Succinic anhydride, b-PEI (MW 1,800), b-PEI (MW 250,000), 2-(7-Azabenzotriazol-1-yl)-N, N, N', N'-tetramethyluronium hexafluorophosphate (HATU), N-ethyldiisopropylamine (DPIEA) et.al was purchased from Adamas-beta (Shanghai, China). All of solvent were purchased from Macklin (Shanghai, China). Chloroquine Phosphate was obtained from Sigma-Aldrich (St. Louis, MO, USA). Antibodies used for Western Blotting and immunofluorescence including rabbit anti-LC3B, anti-p62, anti-Pgp, goat anti-rabbit IgG (H + L) (HRP, Cora Lite 594) were obtained from Proteintech (Wuhan, China). Alexa fluor 647-labeled goat anti-rabbit IgG (H + L), rabbit anti-CD44, anti-ki67, Ad-GFP-LC3B, Lyso-Tracker Red, TUNEL Apoptosis Assay Kit, acid phosphatase assay kit et.al were purchased from Beyotime (Shanghai, China). All other reagents for western blotting and gel electrophoresis were obtained from Solarbio (Beijing, China).
Targeting human P-gp siRNA sequences:
Sense: 5’-AAGAAGGAAAAGAAACCAACUdTdT-3’;
Anti-sense: 5’-AGUUGGUUUCUUUUCCUUCUUdTdT-3’.
All of siRNA were obtained by GenePharma Co. Ltd. (Shanghai, China).

Wang C., Li Z., Xu P., Xu L., Han S, & Sun Y. (2022). Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance. Journal of Nanobiotechnology, 20, 476.

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Synthesis and Characterization of PEGylated Nanoparticles

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PTX was purchased from Beijing Huafeng United Technology Co., Ltd (Beijing, People’s Republic of China). DSF was obtained from Aladdin (Shanghai, People’s Republic of China). Succinic anhydride (SA) and DMA were purchased from Adamas Reagent Co., Ltd (Shanghai, People’s Republic of China) and used as received. N,N-dimethylformamide (DMF) was stored over calcium hydride (CaH₂) and purified by vacuum distillation with CaH₂. Amino-terminated methoxy poly(ethylene glycol) (PEG-NH₂; molecular weight [MW] =5,000) was purchased from Shanghai Yare Biotech, Co., Ltd (Shanghai, People’s Republic of China) and used after dried under vacuum. ε-(Benzyloxycarbonyl)-l-lysine N-carboxyanhydride (Lys(Z)-NCA) were synthesized by the Fuchs-Farthing method using bis(trichloromethyl)carbonate (triphosgene) according to the literature.29 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and Hoechst 33342 were purchased from Beyotime Institute of Biotechnology and used without further purification.

Huo Q., Zhu J., Niu Y., Shi H., Gong Y., Li Y., Song H, & Liu Y. (2017). pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer. International Journal of Nanomedicine, 12, 8631-8647.

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