Sixty minutes after [68Ga]PSMA-11 administration, 58/73 patients underwent PET/MRI (SIGNA PET/3.0 T MRI, GE Healthcare) and 15/73 PET/CT (Discovery VCT 690 or Discovery MI PET/CT, GE Healthcare) scans for staging PCa with an administered [68Ga]PSMA-11 dose of 2 MBq/kg (mean activity 132.9 ± 19.1 MBq, range 94–177). Scans were performed with the same protocol for prostate imaging as recently described [15 (link)]. To reduce the radiopharmaceutical activity in the urinary system, furosemide was injected intravenously 30 min before the tracer injection (0.13 mg/kg), and patients were asked to void before the scan. The institutional protocol was in agreement with the joint EANM-SNMMI procedure guidelines [16 (link)].
Discovery 690 vct
Manufactured by GE Healthcare
Sourced in United States
The Discovery 690 VCT is a high-performance computed tomography (CT) system designed for advanced imaging applications. It features a 64-slice detector configuration and a gantry rotation speed of up to 0.35 seconds per rotation, enabling rapid image acquisition. The system is capable of producing high-quality images with excellent spatial and temporal resolution.
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6 protocols using discovery 690 vct
1
Ga-PSMA-11 PET/MRI and PET/CT for Prostate Cancer Staging
2
Ga-PSMA-11 PET/MRI or PET/CT Imaging
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Patients underwent a clinical routine 68Ga-PSMA-11 PET/MRI (SIGNA PET/MR, GE Healthcare, Waukesha, WI, USA) or 68Ga-PSMA-11 PET/CT (Discovery VCT 690 or Discovery MI PET/CT, GE Healthcare, Waukesha, WI, USA). Images were acquired 60 min after injection of 68Ga-PSMA-11 (mean dose ± standard deviation (SD), 131 ± 19 MBq, range 81–160 MBq). To reduce activity in the urinary system, furosemide was injected intravenously 30 min prior to the tracer injection (0.13 mg/kg) and patients were asked to void prior to the scan. The institutional protocol was in agreement with the EANM and SNMMI procedure guidelines [17 (link)]. Studies were reported in clinical routine by experienced dual board-certified radiologists and nuclear medicine physicians, avoiding known PSMA-positive pitfalls [18 (link), 19 (link)]. More details regarding imaging protocol and analysis are given in the supplements.
3
Prostate Cancer Imaging with 18F-FCH PET/CT
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PET/CT was performed after intravenous injection of 18F-FCH (IASOcholine®, Graz, Austria), according to the body weight of the patient (about 3.5 MBq/kg). The mean radiopharmaceutical dose injected to the patients was 213 MBq (range: 176–346 MBq). 18F-FCH PET/CT images were acquired in median 22 days (range: 8–38) before starting the treatment with docetaxel and in median 26 days (range: 14–58) after the treatment.
Images' acquisition was performed after an uptake time of approximately 60 min on a Discovery-690 VCT (General Electric Medical Systems, GEMS, Milwaukee, WI) scanner [23 (link)].
18F-FCH PET/CT data were acquired for 3 minutes per bed position and reconstructed by using OSEM algorithm (3 iterations, 18 subsets, full width at half maximum (FWHM) of smoothing filter equals to 5 mm) including time of flight and resolution recovery.
Images' acquisition was performed after an uptake time of approximately 60 min on a Discovery-690 VCT (General Electric Medical Systems, GEMS, Milwaukee, WI) scanner [23 (link)].
18F-FCH PET/CT data were acquired for 3 minutes per bed position and reconstructed by using OSEM algorithm (3 iterations, 18 subsets, full width at half maximum (FWHM) of smoothing filter equals to 5 mm) including time of flight and resolution recovery.
4
Multimodal Imaging with Discovery 690 VCT
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All measurements were performed on a Discovery 690 VCT (GE Healthcare, Milwaukee, USA) scanner, which was equipped with 64-slice CT (Light Speed VCT). The 58368 solid state detector elements of the CT scanner were arranged in 912 channels, in 64 rows. The PET component of the Discovery 690 VCT used 4.2×6.3×25 mm3 lutetiumyttrium oxyorthosilicate (LYSO) crystals. The PET scanner consisted of 24 detector rings, with a 157 mm axial field of view (FOV). In the PET scanner, the timing resolution and coincidence time window of the TOF method were approximately 500 ps and 4.9 ns, respectively.
5
PET/CT Imaging Protocol for NSCLC
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All PET/CT imaging was acquired using a Discovery 690 VCT (GE Healthcare, Milwaukee, WI) that is equipped with 64-slice CT (Light Speed VCT; GE Healthcare, Milwaukee, Wisconsin). All patients fasted for at least 4 to 6 hours before 18F-FDG PET scanning and whole-blood glucose concentrations were less than 150 mg/dL before 18F-FDG administration. Whole-body image acquisition was started about 45 to 60 minutes after intravenous injection of 370 to 555 MBq of 18F-FDG (4.6 MBq/kg or 0.125 mCi/kg). The emission scan time per bed position was 2.5 minutes. The PET data were reconstructed using a standard iterative algorithm with attenuation correction based on the CT scan data. SUVmax was determined by drawing regions of interest on the attenuation corrected FDG-PET images around the tumor. It was then calculated by the software contained within the advantage work station (GE, ADW 4.5 PET/CT work station) according to the following formula[37 (link)]:
Maintenance and calibration of PET/CT camera and also the work station remained optimal according to manufacturer guideline to assure consistent and reproducible results. Figures1 and 2 demonstrate FDG-PET/CT scan in 2 NSCLC patients with adenocarcinoma and squamous cell carcinoma pathology, respectively.
Maintenance and calibration of PET/CT camera and also the work station remained optimal according to manufacturer guideline to assure consistent and reproducible results. Figures
6
Anti-NMDAr Encephalitis FDG PET Study
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We retrospectively reviewed the brain FDG PET results of 5 episodes of anti-NMDAr encephalitis in 4 patients. All PET were performed as part of the clinical work-up. To ascertain that the exam was performed interictally, all scans were performed under EEG monitoring beginning 20 minutes before the intravenous injection of 150 to 250 MBq of 18 F-FDG, until 20 minutes thereafter. A 20-minute 3D PET image of the brain was acquired (Discovery 690 VCT, GE Healthcare, Waukesha, Wisconsin, USA). All patients had a brain MRI as part of the clinical evaluation; T1 weighted images were fused to the FDG PET using the PMOD Software (version 3.403, PMOD Technologies Ltd., Zurich, Switzerland). MRI images were used to fit a 67 voxels of interest model to individual anatomical features for which FDG uptake was measured. The patient group was compared to 10 controls of the same mean age from a database of 25 healthy probands 4 . The healthy subjects were processed the same way using the PMOD software, and a voxel based group comparison was performed using SPM8 (P-value < 0.001, corrected for the cluster).
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