The local institutional review board approved all procedures and all participants provided informed consent before data collection commenced. As part of a larger study, all participants completed a neuropsychological battery designed to characterize their functioning on tests of memory and processing speed. The following battery was given during a baseline visit.
After approximately one week (M=7.1 days, SD=0.9, range=6 – 11), the HVLT-R, BVMT-R, SDMT, TMT-A, and TMT-B were repeated. The same form of each test was used to maximize practice effects.
MRI was acquired on a Siemens
Trio 3.0T scanner with a
standard head coil (Siemens, Erlangen, Germany). The imaging protocol was a sagittal 3D magnetization prepared rapid acquisition gradient-echo (MPRAGE) T1-weighted acquisition (inversion time=1000 ms, echo time=2.08 ms, repetition time=2400 ms, flip angle=8 degrees, field of view=224 mm, slice thickness=0.7 mm, 256 slices). All MRI scans were processed on the same workstation using FreeSurfer image analysis suite v5.3.0 (
http://surfer.nmr.mgh.harvard.edu/) to estimate total intracranial and hippocampal volumes. Technical details are described previously [22 (
link)–24 (
link)]. Hippocampal volumes were normalized to total intracranial volume.
Duff K., Anderson J.S., Mallik A.K., Suhrie K.R., Atkinson T.J., Dalley B.C., Morimoto S.S, & Hoffman J.M. (2018). Short-term repeat cognitive testing and its relationship to hippocampal volumes in older adults. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 57, 121-125.