Male nude mice

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Male nude mice are laboratory animals that lack a functional immune system due to genetic modifications. They are commonly used in biomedical research to study the effects of various treatments and interventions without interference from the immune system.

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Lab products found in correlation

C57bl 6, by Orient Bio (1 mentions) Balb c, by Orient Bio (1 mentions)

2 protocols using male nude mice

1

Mouse Models for Immunological Studies

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Six- to seven-week-old male C57BL/6, female BALB/c and male nude mice were obtained from Orient Bio. OT-I mice (Tg(TcraTcrb)1100Mjb) and Batf3^−/- mutant mice (B6.129S(C)-Batf3^tm1.1Kmm/J)in the C5BL/6 background and FVB/N female mice (Tg(MMTVPyVT) 634Mul/J) were purchased from Jackson Laboratory. All animals were maintained in pathogen-free specific facilities and were used in accordance with protocols approved by the Korea Institute Science and Technology (KIST).

Hong Y., Kim Y.K., Kim G.B., Nam G.H., Kim S.A., Park Y., Yang Y, & Kim I.S. (2019). Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity. Journal of Extracellular Vesicles, 8(1), 1670893.

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2

Orthotopic Xenograft HCC Model

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Orthotopic xenografts were established in 8–10-week-old male nude mice (Orient Bio. Gyonggi-Do, Korea). The HCC mice model was created by direct intrahepatic injection of 1 × 10⁶ HLE cells under anesthesia. The HLE cells were transfected with either empty vector, a FAM83H-specific shRNA expression vector, or an overexpression vector for FAM83H. Three mice were used in each experimental group. Animals were euthanized by exsanguination under sodium pentobarbital anesthesia at three weeks after transplantation of HLE cells. Tumor volume in mm³ was calculated by the formula: tumor volume = [(width)² × length/2] mm³.

Kim K.M., Park S.H., Bae J.S., Noh S.J., Tao G.Z., Kim J.R., Kwon K.S., Park H.S., Park B.H., Lee H., Chung M.J., Moon W.S., Sylvester K.G, & Jang K.Y. (2017). FAM83H is involved in the progression of hepatocellular carcinoma and is regulated by MYC. Scientific Reports, 7, 3274.

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