Deltarasin

Manufactured by Bio-Techne

Sourced in Germany

Deltarasin is a chemical compound developed by Bio-Techne for use in laboratory research. It functions as a potent and selective inhibitor of the KRAS protein, a key regulator of cellular signaling pathways. Deltarasin is primarily utilized by researchers in the field of molecular biology and cancer biology to study the role of KRAS in cellular processes and disease mechanisms.

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Lab products found in correlation

Resazurin, by R&D Systems (1 mentions) Victor2 multilabel plate reader, by PerkinElmer (1 mentions) Cysmethynil, by Cayman Chemical (1 mentions)

2 protocols using deltarasin

Organoid Proliferation Assay with Deltarasin

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Organoids were mechanically dissociated by vigorous pipetting. 100 fragments were seeded in 10 µl BME in a 24-well plate. 24 h after seeding, media was removed and replaced with fresh media containing either Deltarasin (Tocris, 5424) (10 µM) or DMSO. Cell proliferation was assessed after 48 h adding 10% Resazurin (R&D systems, AR002). Fluorescence was measured using Victor2 Multilabel Plate Reader (PerkinElmer) as already described.

Hall A.E., Pohl S.Ö., Cammareri P., Aitken S., Younger N.T., Raponi M., Billard C.V., Carrancio A.B., Bastem A., Freile P., Haward F., Adams I.R., Caceres J.F., Preyzner P., von Kriegsheim A., Dunlop M.G., Din F.V, & Myant K.B. (2022). RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nature Communications, 13, 2791.

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KRAS Inhibitor Compound Preparation

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Deltarasin (CAS #1440898-82-7; Tocris Bio-Techne #5424; Wiesbaden-Nordenstadt, Germany), KRAS^G12C inhibitor 12 (AA12; CAS #1469337-95-8; Selleckchem #S7331; Houston, TX, USA), and cysmethynil (CAS #851636-83-4; Cayman Chemicals #14745; Ann Arbor, MI, USA) were dissolved in dimethylsulfoxide (DMSO) until 10 mM stock concentration and stored at −80 °C. For in vitro and in vivo experiments, drugs were further diluted in saline. Equimolar DMSO solutions were used as controls.

Arendt K.A., Ntaliarda G., Armenis V., Kati D., Henning C., Giotopoulou G.A., Pepe M.A., Klotz L.V., Lamort A.S., Hatz R.A., Kobold S., Schamberger A.C, & Stathopoulos G.T. (2022). An In Vivo Inflammatory Loop Potentiates KRAS Blockade. Biomedicines, 10(3), 592.

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