Caspase 3 8g10 and parp 46d11

Manufactured by Cell Signaling Technology

Caspase-3 (8G10) and PARP (46D11) are primary antibodies produced by Cell Signaling Technology. Caspase-3 (8G10) recognizes the full-length and cleaved forms of caspase-3 protein, which is a key executioner of apoptosis. PARP (46D11) recognizes the full-length and cleaved forms of PARP, a substrate of caspase-3 and indicator of apoptosis.

Automatically generated - may contain errors

Lab products found in correlation

Mdm2 sc 965, by Santa Cruz Biotechnology (2 mentions) Pumaα β sc 374223, by Santa Cruz Biotechnology (2 mentions) Mdm2 op46, by Merck Group (2 mentions) P21 dcs60, by Cell Signaling Technology (2 mentions) Hrp conjugated gapdh, by Santa Cruz Biotechnology (2 mentions) Caspase 3 aap 113, by Stressgen (2 mentions)

Close spelling variants of this product

Caspase-3 (2138 citations) PARP (46D11) (15 citations) Caspase-3 (8G10) (10 citations) Caspases (2 citations)

2 protocols using caspase 3 8g10 and parp 46d11

Immunoblotting Protein Expression Assay

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For tumor cell lines, the following primary antibodies were used: PUMAα/β (sc-374223) and MDM2 (SMP-14, sc-965) from Santa Cruz; p53 (DO-1, OP43) and MDM2 (OP46) from Millipore; p21 (DCS60) and Caspase-3 (8G10) and PARP (46D11) from the Cell Signaling Technology. For tumor tissues, the following antibodies were used: p53 (OP43, Millipore), MDM2 (sc-965, Santa Cruz), p21 (556431, BD Biosciences), PARP (9542, Cell Signaling Technology), caspase-3 (AAP-113, Stressgen Bioreagents) and HRP-conjugated GAPDH (sc-5778; Santa Cruz).

Wang S., Sun W., Zhao Y., McEachern D., Meaux I., Barrière C., Stuckey J., Meagher J., Bai L., Liu L., Hoffman-Luca C.G., Lu J., Shangary S., Yu S., Bernard D., Aguilar A., Dos-Santos O., Besret L., Guerif S., Pannier P., Gorge-Bernat D, & Debussche L. (2014). SAR405838: An optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer research, 74(20), 5855-5865.

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Western Blot Analysis of Cellular Proteins

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For western blot analysis in cells, the following primary antibodies were used: PUMAα/β (sc-374223) and MDM2 (SMP-14, sc-965) from Santa Cruz; p53 (DO-1, OP43) and MDM2 (OP46) from Millipore; p21 (DCS60) and Caspase-3 (8G10) and PARP (46D11) from the Cell Signaling Technology. For tumor tissues, the following antibodies were used: p53 (OP43, Millipore), MDM2 (sc-965, Santa Cruz), p21 (556431, BD Biosciences), PARP (9542, Cell Signaling Technology), caspase-3 (AAP-113, Stressgen Bioreagents) and HRP-conjugated GAPDH (sc-5778; Santa Cruz).

Lu J., McEachern D., Li S., Ellis M.J, & Wang S. (2016). Reactivation of p53 by MDM2 inhibitor MI-77301 for the treatment of endocrine-resistant breast cancer. Molecular cancer therapeutics, 15(12), 2887-2893.

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