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2 2 azobis isobutyronitrile aibn

Manufactured by Sinopharm
Sourced in China

2,2'-azobis(isobutyronitrile) (AIBN) is a chemical compound commonly used as a free radical initiator in various chemical processes. It functions by generating free radicals through thermal decomposition, enabling the initiation of polymerization reactions.

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4 protocols using 2 2 azobis isobutyronitrile aibn

1

Synthesis of Cationic Polymers

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Diallyl dimethylammonium chloride ([DADMA]Cl, 60% wt% in water), p-vinylbenzyl trimethylammonium chloride ([VBTMA]Cl), 97%), bromoethane (99%), 1-vinylimidazole (99%), potassium hexafluorophosphate (KPF6, 99%). 2,2’-azobis(isobutyronitrile) (AIBN) was purchased from Sinopharm Chemical Reagent Co. Ltd., Shanghai, China. These chemicals were used as received except that AIBN was purified by recrystallization in methanol.
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2

Synthesis of Stimuli-Responsive Polymers

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1-Vinylimidazole (Vim), Bis(trifluoromethane)sulfonamide (HTFSI), and diethyl ether were purchased from Alfa Aesar (Tianjin, China) and used as received. Toluene (Sinopharm, China) was distilled over sodium under reduced pressure using benzophenone as indicator. 2,2′-Azobisisobutyronitrile (AIBN, Sinopharm, China) was recrystallized in ethanol. Styrene (Sty, Alfa Aesar) was purified through a basic alumina column to remove inhibitor. Pt/C catalyst (20 wt %, Hispec 3000) was purchased from Hesen Electric Co (Shanghai, China). Co3O4 (99%) was supplied by Alfa Aesar (Tianjin, China). IrO2 (85%) was purchased from Kaida Chemical Engineering Company (Shanxi, China). Water was deionized using a Ulupure-H ultrapure water generator (Ulup, China) with resistivity of 18.2 MΩ cm−1.
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3

Synthesis and Characterization of Insulin-Loaded Polymeric Nanoparticles

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AAPBA was purchased from the Beijing Pure Chem. Co., Ltd. (Beijing, China) and DEGMA (98%) and S-1-dodecyl-S′-(α,α′,-dimethyl-α″-acetic acid) trithiocarbonate (DDATC) from Sigma-Aldrich (Shanghai, China). Dimethyl formamide (DMF) and 2,2-azo-bis-isobutyronitrile (AIBN; 97%) were procured from the Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China); the latter was purified by recrystallization from a 5% w/v solution in water before use. Dimethyl sulfoxide (DMSO) was sourced from the China National Medicines Corporation Ltd. (Beijing, China). Insulin with a nominal activity of 28 IU/mg was obtained from the Xuzhou Wanbang Biochemical Co., Ltd. (Jiangsu, China). All solvents used in this work were of analytical grade and were dried by storing over activated 4 Å molecular sieves for 24 h prior to use. Water was triple distilled before use.
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4

Boronic Acid-Functionalized PLGA Microgels for Insulin Delivery

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Poly(lactic-co-glycolic acid) (PLGA; D,L-lactide/glycolide 50/50; Mw 12 kDa) was purchased from the Jinan Daigang Biomaterial Co., Ltd (Jinan, China). Poly(vinyl alcohol) (PVA-1788, medical grade) was obtained from Xi’an Tianzheng Medicinal Materials Co., Ltd (Xian, China). 3-Acrylamido phenylboronic acid (AAPBA) was sourced from the Beijing Pure Chemical Co., Ltd. (Beijing, China), N-vinylcaprolactam (NVCL) was purchased from Hubei Jusheng Co., Ltd. (Wuhan, China) and dimethyl formamide (DMF) and 2,2-azobisisobutyronitrile (AIBN) from the Sinopharm Chemical Reagent Co. (Shanghai, China). Insulin was obtained from Sigma-Aldrich (San Francisco, CA). Dimethyl sulfoxide (DMSO), sodium hydroxide (NaOH) and phosphate buffered saline (PBS) were purchased from the China National Medicines Corporation Ltd. (Beijing, China). All solvents used in this work were of analytical grade.
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