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Tq 320 gc ms ms mass spectrometer

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The TQ 320 GC/MS/MS is a gas chromatography-tandem mass spectrometer (GC/MS/MS) instrument manufactured by Agilent Technologies. The core function of the TQ 320 is to perform high-sensitivity and high-selectivity analysis of complex samples through the combination of gas chromatography and tandem mass spectrometry technologies.

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Ft ir perkin elmer spectrometer, by PerkinElmer (5 mentions) 500 or 700 mhz spectrometer, by Bruker (3 mentions) 240 analyser, by PerkinElmer (2 mentions) 700 mhz spectrometer, by Bruker (1 mentions) Apex 2 d8 venture area diffractometer, by Bruker (1 mentions) 240 analyzer, by PerkinElmer (1 mentions)

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GC-MS Spectrometers

5 protocols using tq 320 gc ms ms mass spectrometer

1

Synthetic Procedures for Thione Derivatives

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Melting points were recorded on a Barnstead 9100 electrothermal melting point apparatus (UK). IR spectra (KBr) were recorded on a FT-IR Perkin-Elmer spectrometer (Perkin Elmer Inc., MA). NMR (1H and 13C NMR) spectra were recorded with Bruker 700 MHz spectrometers (Zurich, Switzerland). Micro-analytical data (C, H, and N) were obtained using a Perkin-Elmer 240 analyser (Perkin Elmer Inc., MA) and agreed with the proposed structures within ±0.4% of the theoretical values. Mass spectra were recorded on a Varian TQ 320 GC/MS/MS mass spectrometer (Varian, Palo Alto, CA). Thione 1 and compounds 8–20 were prepared as described earlier50 (link),51 (link).
El-Azab A.S., Abdel-Aziz A.A., Bua S., Nocentini A., AlSaif N.A., Alanazi M.M., El-Gendy M.A., Ahmed H.E, & Supuran C.T. (2020). S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 733-743.
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2

Characterization of NSAID Thioester Compounds

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Melting points were recorded on a Barnstead 9100 Electrothermal melting apparatus. IR spectra (KBr) were recorded on an FT-IR Perkin-Elmer spectrometer (ν cm−1). 1H and 13C NMR spectra were recorded on Bruker 500 or 700 MHz spectrometers using DMSO-d6 or CDCl3 as the solvent. Microanalytical data (C, H and N) were obtained using a Perkin-Elmer 240 analyser and the proposed structures were within ±0.4% of the theoretical values. Mass spectra were recorded on a Varian TQ 320 GC/MS/MS mass spectrometer. NSAIDs thioester was obtained according to reported method43 .
El-Azab A.S., Abdel-Aziz A.A., Abou-Zeid L.A., El-Husseiny W.M., El_Morsy A.M., El-Gendy M.A, & El-Sayed M.A. (2018). Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 989-998.
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3

Characterization of Compound 8 Crystal

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Melting points were recorded on a Barnstead 9100 electrothermal melting apparatus. IR spectra (KBr) were recorded on an FT-IR Perkin-Elmer spectrometer (ν cm−1). 1H and 13C NMR spectra were recorded on Bruker 500 or 700 MHz spectrometers using DMSO-d6 as the solvent. Microanalytical data (C, H, and N) were obtained using a Perkin-Elmer 240 analyser and the proposed structures were within ±0.4% of the theoretical values. Mass spectra were recorded on a Varian TQ 320 GC/MS/MS mass spectrometer. Data of compound 8 were collected on a Bruker APEX-II D8 Venture area diffractometer (Billerica, MA), equipped with graphite monochromatic Mo Kα radiation, λ = 0.71073 Å at 296 (2) K. Cell refinement and data reduction were carried out by Bruker SAINT. SHELXT35 ,36 was used to solve the structure.
El-Azab A.S., Abdel-Aziz A.A., Ghabbour H.A, & Al-Gendy M.A. (2017). Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 1229-1239.
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4

Synthesis and Characterization of 2-[(3-Substituted-4(3H)-quinazolinon-2-yl)thio]acetohydrazides

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Melting points were recorded on Barnstead 9100 Electrothermal melting point apparatus (UK). IR spectra (KBr) were recorded on a FT-IR Perkin-Elmer spectrometer (Perkin Elmer Inc., MA). Nuclear magnetic resonance (1H and 13C NMR) spectra were recorded on Bruker 500 or 700 MHz spectrometers (Zurich, Switzerland) using DMSO-d6 as the solvent. Microanalytical data (C, H, and N) were performed on a Perkin-Elmer 240 analyzer (Perkin Elmer Inc., MA) and agreed with the proposed structures within ±0.4% of the theoretical values. Mass spectra were recorded on a Varian TQ 320 GC/MS/MS mass spectrometer (Varian, Palo Alto, CA). 2-[(3-Substituted-4(3H)-quinazolinon-2-yl)thio]acetohydrazides (11–15) were prepared according to previously reported methods11 (link),19 (link),22 (link).
El-Azab A.S., Al-Dhfyan A., Abdel-Aziz A.A., Abou-Zeid L.A., Alkahtani H.M., Al-Obaid A.M, & Al-Gendy M.A. (2017). Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 935-944.
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5

Synthesis of 4-(2-(4-Oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl)ethyl)benzenesulfonamide

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Melting points were recorded on a Barnstead 9100 electrothermal melting point apparatus (UK). IR spectra (KBr) were recorded on a FT-IR Perkin-Elmer spectrometer (Perkin Elmer Inc., Waltham, MA). Nuclear magnetic resonance (1H and 13C NMR) spectra were recorded with Bruker 500 or 700 MHz spectrometers (Zurich, Switzerland) using DMSO-d6 as the solvent. Micro-analytical data (C, H, and N) were obtained using a Perkin-Elmer 240 analyser (Perkin Elmer Inc., MA) and agreed with the proposed structures within ±0.4% of the theoretical values. Mass spectra were recorded on a Varian TQ 320 GC/MS/MS mass spectrometer (Varian, Palo Alto, CA).
4-(2-(4-Oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl)ethyl)benzenesulfonamide compound 1 was prepared by heating anthranilic acid with 4-(2-isothiocyanatoethyl)benzenesulfonamide in ethanol in the presence of triethylamine40 (link).
El-Azab A.S., Abdel-Aziz A.A., Ahmed H.E., Bua S., Nocentini A., AlSaif N.A., Obaidullah A.J., Hefnawy M.M, & Supuran C.T. (2020). Exploring structure-activity relationship of S-substituted 2-mercaptoquinazolin-4(3H)-one including 4-ethylbenzenesulfonamides as human carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 598-609.
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