Sts 135

Manufactured by Cayman Chemical

STS-135 is a laboratory centrifuge designed for general purpose applications. It has a maximum speed of 4,500 RPM and can accommodate a variety of rotor types. The centrifuge is suitable for common laboratory procedures such as sample preparation and separation.

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Lab products found in correlation

Methanol, by Thermo Fisher Scientific (2 mentions) Lc ms grade acetonitrile, by Merck Group (1 mentions) Lc ms water, by Thermo Fisher Scientific (1 mentions) Nadph regenerating systemsolutions a and b, by Corning (1 mentions)

2 protocols using sts 135

Cryopreserved Hepatocyte Protocol

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Cryopreserved human hepatocytes, human liver microsomes, thawing and incubation media and NADPH regenerating system solutions were purchased from BioreclamationIVT (Baltimore, MD). STS-135 was obtained from Cayman Chemicals (Ann Arbor, MI). LC-MS-grade acetonitrile and water were supplied by Sigma-Aldrich (St. Louis, MO).

Gandhi A.S., Wohlfarth A., Zhu M., Pang S., Castaneto M., Scheidweiler K.B, & Huestis M.A. (2014). High-resolution mass spectrometric metabolite profiling of a novel synthetic designer drug, N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135) using cryopreserved human hepatocytes and assessment of metabolic stability with human liver microsomes. Drug testing and analysis, 7(3), 187-198.

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STS-135 Metabolism in Biological Samples

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All chemicals used for this study were of at least reagent grade. STS‐135 was obtained from Cayman Chemical. Pooled HLMs, genotyped HLMs, recombinant P450s, human brain microsomes (HBMs), and NADPH Regenerating System Solutions A and B were purchased from Corning. Human intestinal microsomes (HIMs) were purchased from Xenotech. LC/MS water, methanol, and acetic acid grade were purchased from Thermo Fisher Scientific. All other chemicals and reagents were purchased from Sigma‐Aldrich or Thermo Fisher Scientific, unless specified otherwise.

Jones S., Yarbrough A.L., Fantegrossi W.E., Prather P.L., Bush J.M., Radominska‐Pandya A, & Fujiwara R. (2020). Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1H‐indole‐3‐carboxamide (STS‐135). Pharmacology Research & Perspectives, 8(1), e00561.

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