Pathogen-free, male C57BL/6 mice, 6 to 8 weeks old, weighing 19 to 21 g were purchased from Orient Bio (Sungnam, Korea). B6.129-Mertktm1Gr1/J (MerTK−/−) and wild-type (WT) control mice with an identical background (B6.129SF2/J) were obtained from The Jackson Laboratory (Bar Harbor, Maine, USA). STAT1−/− mice were from the Charles River Laboratory. STAT1−/− mice were on a C57BL/6 background (Orient Bio). MerTK−/−, STAT1−/−, and the respective WT mice were age-matched (7 to 10 weeks old) and sex-matched for all experiments. The Animal Care Committee of the Ewha Medical Research Institute approved the experimental protocol. Mice were cared for and handled in accordance with the National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals.
Stat1 mice
Manufactured by Charles River Laboratories
STAT1−/− mice are genetically engineered mice that have a disruption in the STAT1 gene, resulting in the absence of the STAT1 protein. STAT1 is a key signaling molecule involved in the immune response. These mice can be used to study the role of STAT1 in various biological processes.
Automatically generated - may contain errors
2 protocols using stat1 mice
1
Pathogenic Mouse Models for Immunological Research
2
Transgenic Mouse Strains for Immunology Research
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WT C57BL/6J mice were purchased from Janvier Elevage. C57BL/6J (originally from Janvier Elevage), Maxi transgenic (CD45.1) mice expressing a TCR specific for MCMV peptide M38316–323 (Torti et al., 2011 (link)), P14 transgenic (CD45.1) mice expressing a TCR specific for LCMV peptide gp3333–41 (Pircher et al., 1990 (link); Torti et al., 2011 (link)), PKOB−/− (Kägi et al., 1994 (link)), CD45.1 OT-I mice expressing a TCR specific for OVA257–264 SIINFEKL peptide (Hogquist et al., 1994 (link)), CD45.1 OT-I Rag1−/−, and CD45.1 OT-I Stat1−/− (the Stat1−/− mice were purchased from Charles River Laboratories and crossed to the CD45.1 OT-I line) were housed and bred under specific pathogen–free conditions at the ETH Phenomics Center Hönggerberg. All KO and transgenic mice strains were crossed on a C57BL/6 background for >10 generations. All mice were used between 6–12 wk of age and sex-matched within all experiments. All animal experiments were performed according to the institutional policies and Swiss federal regulations, and those were approved by the Cantonal Veterinary Office of Zürich (Animal experimentation permissions 228/2013, 166/2016).
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