Flash 3d software

Three hours after injection of approximately 185 MBq of ¹²³I-FP-CIT, projection data were obtained in a 128 × 128 matrix on a Siemens Symbia T16 mounted with low- to medium-energy general purpose (LMEGP) collimators. Projection data were acquired for 28 min. Data were reconstructed by ordered subset expectation maximization (OSEM) method (iteration 8, subset 6) using Flash 3D software (Siemens) and corrected for attenuation by CT. The specific binding ratio (SBR) was semiquantitatively calculated using DAT VIEW software (Nihon Medi-Physics, Tokyo, Japan) based on Bolt’s method, as described in detail elsewhere [40 (link)]. For this study, we used SBR as the mean value of the right and left SBRs. The control group for DAT SPECT consisted of 18 subjects without any present or previous neurological disease (7 men and 11 women, mean age 78.6 ± 6.5 years). The mean SBR of the controls was 5.84 ± 0.83. Values were considered abnormal if they were less than 2 SDs below the control mean.

All studies were uniformly processed with commercially available E.soft software (Siemens, USA) on a Syngo nuclear medicine workstation (Siemens, USA). SPECT images were reconstructed with the Flash-3D software (Siemens Medical Solutions, USA) with 8 subsets and 4 iterations. Subsequently, tomographic slices were generated and displayed as transaxial, coronal, and sagittal slices. SPECT emission images were co-registered and fused with CT images using the object versus the target matrix method.