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5 protocols using scotch blue painter s tape 50 mm

1

Screening Polymers for 3D Printing and Formulation

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A variety of polymers was screened to investigate their window of feed-and printability. Thermoplastic polyurethanes (Tecoflex R EG-72D, Tecophilic R SP-60D-60 Tecophilic R SP-93A) (Lubrizol, Ohio, USA) and ethylene-vinyl-acetates (EVA1070, EVA2825A) (Celanese, UK) were processed as pellets. Polycaprolactone (CAPA 6506, Perstorp, UK), polyethylene-oxide (Polyox WSR N10, Dupont, Germany), polymethacrylates (Eudragit EPO, Evonik, Germany), hydroxy-propylcellulose (Klucel EF, Ashland, Switzerland), polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus R ,BASF, Germany) and copovidone (Kollidon VA64 R , BASF, Germany) were processed as powder. From this list of polymers, the TPUs and CAPA6506 are at this moment not approved for pharmaceutical use in Europe. Black polylactic acid filament was purchased from 3D4Makers (Haarlem, Netherlands). Ibuprofen (SI group, USA) was added as active pharmaceutical ingredient (API) to Polyox WSR N10 (PEO N10) and polycaprolactone (PCL) in 20% (w/w) and 40% (w/w). Scotch blue painter's tape 50 mm was supplied by 3M (Bracknell, UK).
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2

Formulation of Theophylline and Dipyridamole

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Theophylline (melting point 270 o C) (21) was purchased from Acros Organics.
Polyvinylpyrrolidone (PVP, MW 40,000) and dipyridamole (melting point 165 o C) (22) were purchased from Sigma-Aldrich (UK). Talc was ordered from Fluka Analytical (UK). Triethyl citrate was purchased from Sigma-Aldrich (Dorset,UK) and Scotch blue painter's tape 50 mm was supplied by 3M (Bracknell, UK).
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3

Warfarin Formulation Development

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Warfarin (sodium salt) was purchased from Arcos (UK). Eudragit E was donated from Evonik Industries (Darmstadt, Germany). Triethyl citrate (TEC) and tri-calcium phosphate (TCP) were supplied by Sigma-Aldrich (UK). Acetonitrile and methanol were supplied by British Drug Houses (BDH, London, UK). Scotch Blue Painter's tape 50 mm was supplied by 3M (Bracknell, UK).
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4

Theophylline and Eudragit EPO Formulations

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Theophylline (Tm=273°C) was purchased from Arcos (UK). Eudragit EPO was donated by Evonik Industries (Darmstadt, Germany). Triethyl citrate (TEC), tri-Calcium phosphate (TCP), talc, 5-ASA (Tm=283°C), captopril (Tm=103°C) and prednisolone (Tm=230°C) were supplied by Sigma-Aldrich (UK). Scotch blue painter's tape 50 mm was supplied by 3M (Bracknell, UK). Spray-dried lactose, directly compressible lactose Ludipress ® and microcrystalline cellulose (MMC) Avicel ® were purchased from FMC biopolymers (UK).
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5

Theophylline Controlled-Release Formulations

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Theophylline was purchased from Arcos (UK). Eudragit® RL100 and Eudragit® RS100 formulation were donated by Evonik Industries (Darmstadt, Germany). Hydroxypropyl cellulose SSL grade was donated by Nisso Chemical Europe GmbH (Dusseldorf, Germany).
Triethyl citrate (TEC) and triacetin were supplied by Sigma-Aldrich (UK). Scotch blue painter's tape 50 mm was supplied by 3M (Bracknell, UK).
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