All patients underwent 18F-FDG PET/CT scan using either a Biograph 40 TruePoint PET/CT scanner (Siemens Healthcare, Erlangen, Germany) or Discovery STe PET/CT scanner (GE Healthcare, Waukesha, WI, USA). The patients fasted for at least 6 h, and glucose levels in the peripheral blood were confirmed to be lower than 140 mg/dL before 18F-FDG injection. Approximately 5.5 MBq of 18F-FDG per kilogram of body weight was administered intravenously 1 h before image acquisition. After the initial low-dose CT (Biograph 40 TruePoint, 36 mA, 120 kVp; Discovery STe, 30 mA, 130 kVp) without contrast-enhancement, standard PET imaging from the neck to the proximal thighs with an acquisition time of 2.5 min/bed position in 3-dimensional mode was performed. The PET images were reconstructed using ordered-subset expectation maximization (2 iterations, 20 subsets).
Biograph 40 truepoint pet ct scanner
Manufactured by Siemens
Sourced in United States
The Biograph 40 Truepoint PET/CT scanner is a medical imaging device that combines Positron Emission Tomography (PET) and Computed Tomography (CT) technologies. It is designed to acquire high-quality, three-dimensional images of the body's internal structures and functions.
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Lab products found in correlation
Biograph vision 450 pet ct scanner, by Siemens (2 mentions)
Discovery ste pet ct scanner, by GE Healthcare (1 mentions)
Omnipaque 350, by GE Healthcare (1 mentions)
Biograph 16 pet ct scanner, by Siemens (1 mentions)
Discovery st pet ct instrument, by GE Healthcare (1 mentions)
18f av 1451 pet scans, by Siemens (1 mentions)
Aquarius intuition viewer software, by TeraRecon (1 mentions)
Somatom definition flash, by Siemens (1 mentions)
Somatom sensation 64, by Siemens (1 mentions)
Biograph mmr pet mr scanner, by Siemens (1 mentions)
10 protocols using biograph 40 truepoint pet ct scanner
1
18F-FDG PET/CT Imaging Protocol
2
PET Imaging of Dopamine Metabolism
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All participants were asked to fast and abstain from smoking and drinking from midnight on the day of the scan and received 400 mg of entacapone, a peripheral catechol-o-methyl-transferase inhibitor, and 150 mg of carbidopa to prevent formation of radiolabeled metabolites that may cross the blood-brain barrier [34 (link)]. Imaging data were obtained on a Biograph 40 Truepoint PET/CT scanner (Siemens, Knoxville, TN, USA) and after acquiring a computed tomography scan for attenuation correction, [18F] DOPA was administered by bolus intravenous injection of 370 MBq or less (10 mCi) of [18F] DOPA with minimum specific activity of 1.30×107 Ci/mol. Head position was marked and monitored, and movement was minimized using a head strap. After routine corrections for uniformity, decay corrections, and attenuation (using the CT), the PET imaging data acquired in a list mode were reconstructed with a filtered back projection using a Gaussian filter. PET data were acquired for 95 min in a three-dimensional mode with 148 axial slices, an image size of 256×256, a pixel size of 1.3364×1.3364 mm2, and a slice thickness of 3 mm. The dynamic volumetric images were sequenced using the following framing: 2×30, 4×60, 3×120, 3×180, and 15×300 s.
3
FDG PET/CT Patient Preparation
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Patient preparation for 18F-FDG PET/CT included a minimum of 4 h of fasting which is in keeping with published guidelines [25 (link),26 (link)]. Blood sugar before 18F-FDG injections was less than 7.1 mmol/L in all cases. The injected activity of 18F-FDG was between 3–5 MBq/kg. We imaged patients after an uptake period of 60 min. Thirteen of the patients were imaged on a Biograph 40 Truepoint PET/CT scanner (Siemens Medical Solutions, Lincolnshire, IL, USA), while the other seven were imaged on a Biograph Vision 450 PET/CT scanner (Siemens Medical Solutions, Lincolnshire, IL, USA). We performed a vertex to mid-thigh CT scan with parameters adjusted for patients’ weight (120 KeV, 40–150 mAs) with a section width of 5 mm and pitch of 0.8.
4
Synthesis and PET Imaging of [68Ga]Ga-FAPI-46
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The synthesis of [68Ga]Ga-FAPI-46 was performed as previously described [15 (link)]. Briefly, we obtained 68Ga from our in-house 68Ge/68Ga generator (iThemba LABS, Somerset West, South Africa). The FAPI peptide was obtained from SOFIE Biosciences, Inc., Culver City, CA, USA. The radiolabeling was conducted in-house and the labelling efficiency exceeded 95%. There was no specific patient preparation applied for the [68Ga] Ga-FAPI PET scan. The mean injected activity of [68Ga]Ga-FAPI was 5 ± 0.6 mCi/185 ± 22.2 MBq (range: 4.2–6 mCi). After an uptake period of 60 min, we acquired whole-body (vertex to mid-thigh) images. PET imaging was acquired in 3D mode at 3 min per bed position. Ordered subset expectation maximization (OSEM) iterative reconstruction algorithm (four iterations, eight subsets) was performed on the images followed by post-reconstruction filtering. The CT scan was a non-diagnostic scan and was performed in line with recommendations and as per our departmental protocol (previously published [26 (link)]). All patients were imaged on one of two systems, namely the Biograph 40 Truepoint PET/CT scanner (Siemens Medical Solutions, Hoffman Estates, IL, USA) and the Biograph Vision 450 PET/CT scanner (Siemens Medical Solutions, IL, USA).
5
Protocol for 68Ga-PSMA-11 PET/CT Imaging
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68Ga-PSMA-11 was prepared in house as previously described by our group [13 (link)]. An average of 1.85 MBq per kilogram 68Ga-PSMA-11 was injected intravenously. The median injected activity was 133 MBq (range, 59.2–247.9 MBq). Radiochemical purity of injected radiopharmaceutical was above 95% in all participants. Whole-body PET/CT imaging from vertex to mid-thigh was performed at 60 min post-injection (range, 60–70 min). A low-dose non-diagnostic CT without contrast was performed for anatomical localization and attenuation correction. There was no special preparation prior to imaging. Patients were requested to void fully just prior to imaging beginning. All patients were imaged on a Biograph 40 Truepoint PET/CT scanner (Siemens Medical Solution, Malvern, PA, USA). Image reconstruction was completed with an ordered subset expectation maximization iterative reconstruction algorithm (four iterations, eight subsets). A Gaussian filter was applied at 5.0 mm FWHM.
6
Standardized PET/CT Imaging Protocol
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Imaging was done as previously reported. 11 Briefly, all patients fasted for a minimum of six hours. Blood sugar before imaging was B 11.0 mmol/L in all patients. The activity of FDG administered was weight-based, and calculated using the formula: Activity administered = [(body weight in Kg 7 10)?1] 9 37 Mega Becquerel (MBq). Imaging was See related editorial, pp. 1266-1268 acquired on a Biograph 40 Truepoint PET/CT scanner (Siemens Medical Solution, Illinois, USA). Intravenous contrast, 100 mL Omnipaque 350 (GE Healthcare, Wisconsin, USA) was given after a scan delay time of 80 seconds. CT parameters were adjusted for patients' weight (120KeV, 40-150 mAs) with a section width of 5 mm and pitch of 0.8. Vertex to midthigh PET imaging was acquired in 3D mode at 3 minutes per bed position. Computed tomography data were used for attenuation correction. Image reconstruction was done with the ordered subset expectation maximization iterative reconstruction algorithm (4 iterations, 8 subsets). A Gaussian filter was applied at 5.0 mm full width at half maximum (FWHM).
7
Standardized PET/CT Imaging Protocol
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PET/CT scans were acquired after a single FDG injection. Patients fasted for 6 hours before the 18F-FDG injection (serum glucose level <180 mg/dL). FDG dose was corrected for body mass index at all centers. The scan was obtained from the subcranial region to the upper thigh (torso) 60 to 90 minutes after the injection. A low-dose CT acquisition without contrast enhancement (NE CT) was initiated first, followed by PET acquisition. Then, the CE CT scans were collected. Iterative reconstruction was done using ordered-subset expectation maximization software. The attenuation was corrected by NE CT. NE PET/CT was not performed at one institution, and CE PET/CT was used for attenuation correction in these patients (n=14).
The PET/CT machines used in this study were as follows: the Biograph TruePoint 40 PET/CT scanner (Siemens Medical Solutions, Knoxville, TN, USA) or the Biograph 16 PET/CT scanner (Siemens Medical Solutions), the Discovery ST PET/CT instrument (GE Medical Systems, Milwaukee, WI, USA), the Discovery ST PET/CT instrument (GE Medical Systems), the Discovery VCT PET/CT instrument (GE Medical Systems), and the Gemini TF (Philips-ADAC Medical Systems, Cleveland, OH, USA). The workstations used for reconstruction were the Syngo multimodality workplace, Exeleris Advanced Workstation 4.4 (GE Medical Systems).
The PET/CT machines used in this study were as follows: the Biograph TruePoint 40 PET/CT scanner (Siemens Medical Solutions, Knoxville, TN, USA) or the Biograph 16 PET/CT scanner (Siemens Medical Solutions), the Discovery ST PET/CT instrument (GE Medical Systems, Milwaukee, WI, USA), the Discovery ST PET/CT instrument (GE Medical Systems), the Discovery VCT PET/CT instrument (GE Medical Systems), and the Gemini TF (Philips-ADAC Medical Systems, Cleveland, OH, USA). The workstations used for reconstruction were the Syngo multimodality workplace, Exeleris Advanced Workstation 4.4 (GE Medical Systems).
8
Quantifying Cerebral Tau Deposition via AV-1451 PET
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A subset of subjects (n = 107) underwent [18F] AV-1451 PET scans (Siemens) using a Biograph True point 40 PET/CT scanner (Siemens), in accordance with the manufacturer’s guidelines. While all the other neuroimaging scans were performed during the baseline visit, AV-1451 PET imaging was performed at an average of 2.6 (standard deviation 0.3) years after the baseline visit. The details of AV-1451 PET imaging acquisition and preprocessing were described previously (Park et al., 2019 (link)). To estimate cerebral tau deposition, we quantified AV-1541 SUVR of an a priori ROI of “AD-signature regions” of tau accumulation, which comprised a size-weighted average of partial volume-corrected uptake in entorhinal, amygdala, parahippocampal, fusiform, inferior temporal, and middle temporal ROIs, in accordance with the method used in a previous report (Jack et al., 2017 (link)). The AV-1541 SUVR of the abovementioned ROI was used as an outcome variable for cerebral tau deposition.
9
Skeletal Muscle Area Measurement via CT
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Skeletal muscle area was measured at the level of the L3 vertebra, with the patients in the supine position, using either a dual-source, 128-slice CT scanner (Somatom Definition Flash; Siemens Healthcare, Forchheim, Germany), a 64-slice CT scanner (Somatom Sensation 64; Siemens Healthcare), a 128 slice Discovery 710 PET-CT scanner (General Electric Medical Systems, Milwaukee, WI, USA), a 40 slice Biograph TruePoint 40 PET-CT scanner (Siemens Medical Solutions, Hoffman Estates, IL, USA), or a 16 slice Discovery 600 PET-CT scanner (General Electric Medical Systems). The muscle area was identified as having attenuation values between –29 and 150 Hounsfield units, and the total lumbar skeletal muscle area (psoas, erector spinae, quadratus lumborum, transversus abdominus, external and internal obliques, and rectus abdominus), measured in cm2, was defined as the region with density ranging from –29 to –150 Hounsfield units, as measured using Aquarius Intuition Viewer software, version 4.4.12 (Terarecon, San Mateo, CA, USA). Boundaries were corrected manually as necessary. To determine the lumbar skeletal muscle index (LSMI; cm2/m2), the skeletal muscle area at the L3 vertebra was normalized to the square of the patient’s height (m2).16 (link),17 (link)
10
Multimodal Neuroimaging Protocol for Alzheimer's
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All participants underwent simultaneous three‐dimensional [11C] Pittsburgh compound B (PiB) PET and MRI, including three‐dimensional (3D) T1‐weighted images, 3D fluid‐attenuated inversion‐recovery (FLAIR) images, T2‐weighted images, and susceptibility‐weighted images using a 3.0 T Biograph mMR (PET‐MR) Scanner (Siemens, Washington DC, USA). Three‐dimensional T1‐weighted images and FLAIR images were acquired in the sagittal plane. Acquisition parameters for 3D T1‐weighted images were as follows: repetition time (TR), 1670 ms; echo time (TE), 1.89 ms; field of view (FOV), 250 mm; matrix, 256 × 256; slice thickness, 1.0 mm. The parameters for acquiring 3D FLAIR images were as follows: TR, 5000 ms; TE, 173 ms; echo spacing, 3.46 ms; FOV, 250 mm; matrix size, 256 × 256; slice thickness, 1.0 mm. Acquisition parameters for T2‐weighted images were as follows: TR, 5000 ms; TE, 91 ms; FOV, 199 × 200 mm; matrix size, 640 × 348; and slice thickness, 3.0 mm. Acquisition parameters for susceptibility‐weighted images were as follows: TR, 1670 ms; TE, 1.9 ms; FOV, 250 mm; matrix size, 448 × 255; and slice thickness, 3.0 mm. All participants also underwent [18F] AV‐1451 PET scans using a Biograph True Point 40 PET/CT Scanner (Siemens, Washington DC, USA).
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