Poly lactic co glycolic acid

The optofluidic devices were implanted into the brain of adult mice following a similar method used for our previous soft neural implants.^{[25 (link)]} Animals were mounted into a stereotaxic apparatus and anesthetized using isoflurane, while they rested on a heating pad for the duration of the procedure. After securing its head onto the apparatus, the mouse’s skull was exposed via a superficial midline incision performed under aseptic conditions. Following the identification of the desired stereotaxic coordinates for the implantation of the device, it was proceeded to drill a small opening for placement of the optofluidic probe. The soft RF harvester was implanted under the skin, caudal to the injection site. Placement of the optofluidic probe into the brain cortex was performed using a stereotaxic holder adapted for these devices, following temporary stiffening of the implant with a biodegradable polymer (poly(lactic-co-glycolic acid); Sigma-Aldrich Inc.). After the implant was secured, the mouse’s skin was sutured and the animal was set aside for recovery. The step-by-step process of the surgery can be found in Figure S9 in the Supporting Information. This same method can be referenced in Park et al.^{[25 (link)]}