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Teklad 2018

Manufactured by Inotiv
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Sourced in United States

Teklad 2018 is a laboratory animal diet that provides a nutritionally complete and balanced diet for rodents. It is formulated to meet the nutritional requirements of laboratory animals and is designed to support their health and well-being. The product's core function is to serve as a consistent and reliable source of nutrition for laboratory animals used in research and testing.

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Lab products found in correlation

Male sprague dawley rats, by Inotiv (2 mentions) Wistar rats, by Inotiv (2 mentions) C57bl 6j mice, by Jackson ImmunoResearch (2 mentions) Long evans rat, by Inotiv (1 mentions) B6 cg tg actflpe 9205dym j, by Jackson ImmunoResearch (1 mentions) Actin flpase mice, by Jackson ImmunoResearch (1 mentions) High fat diet (hfd), by Research Diets (1 mentions) Recombinant irisin, by Adipogen (1 mentions) Ain93g chow, by Research Diets (1 mentions) Sprague dawley rats, by Inotiv (1 mentions) Irisin, by Adipogen (1 mentions) Sprague dawley rat, by Charles River Laboratories (1 mentions) Adult male sprague dawley rats, by Inotiv (1 mentions)

15 protocols using teklad 2018

1

Sprague Dawley Rats in Behavioral Testing

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Male Sprague Dawley rats were purchased from Envigo Laboratories (Indianapolis, IN). Rats were maintained in standard rodent plastic shoebox cages until at least 1 week before behavioral testing, at which time they were singly housed in hanging wire-mesh stainless steel cages affixed with an electrically isolated metal plate with 3.2 mm openings through which rats need to lick to reach a spout on the other side. Rats had ad libitum access to food (Teklad 2018; Envigo Laboratories) tap water, and were also given a second bottle containing 1.5% saline for at least a week before the start of experiments, and throughout the entire experiment. The temperature- and humidity-controlled colony rooms were maintained on a 12:12 h light-dark cycle. All experiments occurred during the early portion of the light phase. All experimental protocols were approved by the University at Buffalo Institutional Animal Care and Use Committee, and the handling and care of the animals was in accordance with the NIH Guide for the Care and Use of Laboratory Animals.
Pang H.W., Linares A., Couling L., Santollo J., Ancheta L., Daniels D, & Speth R.C. (2019). Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways. Endocrine, 66(2), 349-359.
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2

Sprague Dawley Rat Housing and Care

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Male Sprague Dawley rats (200–250 g) were ordered from Envigo Laboratories (Indianapolis, IN). All rats were individually housed in hanging stainless-steel, wire mesh cages (Unifab, Kalamazoo, MI) in a temperature and humidity controlled room on a fixed 12-h light, 12-h dark cycle. Experimental injections started during the first 2–4 h of the light portion of the cycle. Food (Teklad 2018; Envigo Laboratories) and tap water were accessible ad libitum, unless otherwise noted. All experimental procedures were approved by the Institutional Animal Care and Use Committee of the State University of New York at Buffalo.
Postolache M., Santollo J, & Daniels D. (2017). Associative learning contributes to the increased water intake observed after daily injections of angiotensin II. Physiology & behavior, 179, 340-345.
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3

Wistar Rat Diet and Acclimation

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Adult male Wistar rats (220‐250 g starting bodyweight, Harlan, San Diego, CA and Envigo, Tampa, FL) were individually housed at 22°C under a 12‐h light‐dark cycle with ad libitum access to water and either chow (3.1 kcal/g, Teklad 2018, Envigo, Sommerset, NJ) or HFHS diet (45% calories from fat; 4.7 kcal/g, Research Diets D12451, New Brunswink, NJ), unless stated otherwise. Animals were allowed for 1 week to acclimate before any experiments were started. All experiments were approved by the University of Florida, and John B. Pierce Laboratory Institutional Animal Care and Use Committees (IACUC).
McDougle M., Quinn D., Diepenbroek C., Singh A., de la Serre C, & de Lartigue G. (2020). Intact vagal gut‐brain signalling prevents hyperphagia and excessive weight gain in response to high‐fat high‐sugar diet. Acta Physiologica (Oxford, England), 231(3), e13530.
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4

Murine Model of Mucopolysaccharidosis Type I

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All studies were approved by the University of Southern California Institutional Animal Care and Use Committee and conducted following the NIH Guide for the Care and Use of Laboratory Animals. Breeder pairs of NOD.129(B6)‐Prkdcscid Iduatm1Clk mice heterozygous for the IDUA mutation (#004083) were obtained from The Jackson Laboratory (The Jackson Laboratory, Bar Harbor, ME, www.jax.org/), housed under specific‐pathogen‐free conditions and provided with standard chow (TEKLAD #2018, Envigo, Huntingdon, Cambridgeshire, UK, www.envigo.com) and sterile/acidified water. Homozygous knockout (MPS1) mice start to develop disease phenotype including flattened facial profile, broadened head, thickened digits at 3 weeks of age. Severe phenotypes such as defective bone formation and broadening of the zygomatic bone have established by 8 weeks 34 (Supporting Information Fig. S2A). PCR‐based genotyping was performed with specific primers according to the Jackson Laboratory's instructions.
Rodriguez N.S., Yanuaria L., Parducho K.M., Garcia I.M., Varghese B.A., Grubbs B.H, & Miki T. (2017). Liver‐Directed Human Amniotic Epithelial Cell Transplantation Improves Systemic Disease Phenotype in Hurler Syndrome Mouse Model. Stem Cells Translational Medicine, 6(7), 1583-1594.
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5

Long Evans Rat Housing and Care

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Adult female Long Evans rats (Envigo) were used throughout the experiments. Rats were between 75 and 120 days of age at the start of the experiments. Rats were singly housed in modified shoebox cages (two external lick blocks) with ad libitum access to food (Teklad 2018; Envigo), tap water, and 1.5% saline solution (Experiment 1b) unless otherwise noted. The temperature- and humidity-controlled colony rooms were maintained on a 12:12 h light-dark cycle (lights on at 0100 h Experiment 1, 2, & 3; lights on at 0700 h Experiment 4). All experimental protocols were approved by the Animal Care and Use Committee at the University of Kentucky, and the handling and care of the rats was in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals.
Santollo J., Edwards A.A., Howell J.A, & Myers K.E. (2021). Bidirectional effects of estradiol on the control of water intake in female rats. Hormones and behavior, 133, 104996.
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6

Wistar Rat Dietary Intake Study

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Adult male Wistar rats (220–250 g starting bodyweight, Harlan, San Diego, CA and Envigo, Tampa, FL) were individually housed at 22°C under a 12-h light-dark cycle with ad libitum access to water and either chow (3.1 kcal/g, Teklad 2018, Envigo, Sommerset, NJ) or HFHS diet (45% calories from fat; 4.7 kcal/g, Research Diets D12451, New Brunswink, NJ), unless stated otherwise. Animals were allowed one week to acclimate before any experiments were started. All experiments were approved by the University of Florida, and John B. Pierce Laboratory Institutional Animal Care and Use Committees (IACUC).
McDougle M., Quinn D., Diepenbroek C., Singh A., de la Serre C, & de Lartigue G. (2020). Intact vagal gut‐brain signalling prevents hyperphagia and excessive weight gain in response to high‐fat high‐sugar diet. Acta Physiologica (Oxford, England), 231(3), e13530.
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7

Wistar Rat Habituation and Feeding Protocol

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Male (n = 16) and female (n = 14) Wistar rats (weighing 200–224 g for females and 250–274 g for males and matched for age at arrival) from Envigo Inc. (Madison, WI, United States) were used as subjects. Rats were initially housed in pairs in plastic home cages for a minimum of 3 days to allow for habituation to the facility. Food (Teklad 2018, Envigo Inc.) and water were available ad libitum during habituation. At the start of the experiment, rats were housed individually in experimental chambers. Rooms were maintained at 24° C and 40–50% humidity. All experiments occurred during the light cycle with a 12 h on/12 h off cycle (lights on at 600). Access to water was ad libitum during the experiments, but food was limited to 16 g for female rats and 20 g for male rats and was given 4 h after session conclusion. All experimental details were approved by the Institutional Animal Care and Use Committee at the University of Minnesota and performed in compliance with the Guide for the Care and Use of Animals (National Research Council, 2011 ). Research facilities were accredited by the American Association for the Accreditation of Laboratory Animal Care.
Swalve N., Smethells J.R., Younk R., Mitchell J., Dougen B, & Carroll M.E. (2017). Sex-specific attenuation of impulsive action by progesterone in a Go/No-go task for cocaine in rats. Psychopharmacology, 235(1), 135-143.
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8

Behavioral Characterization of S426A/S430A Mutant Mice

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This study was performed using 235 experimentally naïve male S426A/S430A mutant (n = 115) and wild-type (n = 120), 8-12-week-old, littermate-controlled mice on a C57BL/6 background. The generation of S426A/S430A mutant mice has been described previously (Morgan et al., 2014 (link)). After weaning, mice were group housed, with a standard 12:12h light/dark cycle (lights on at 07:00, lights off at 19:00). Mice were provided with ad libitum access to standard rodent chow (Teklad 2018, Envigo, Indianapolis, IN) and water. All animal care procedures were performed in accordance with the Guidelines of the National Institutes of Health on the Care and Use of Animals and with approval from the Pennsylvania State University College of Medicine Institutional Animal Care and Use Committee (IACUC).
Nealon C.M., Henderson-Redmond A.N., Hale D.E, & Morgan D.J. (2019). Tolerance to WIN55,212-2 is delayed in desensitization-resistant S426A/S430A mice. Neuropharmacology, 148, 151-159.
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9

Generation and Characterization of Transgenic Mice

Cited 2 times
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WT/SAVI(N153S) mice were purchased from The Jackson Laboratory. HAQ, AQ mice were previously generated in the lab 33 (link),34 (link). The Q293 mice were generated by Cyagen Biosciences. Briefly, the linearized targeting vector was transfected into JM8A3.N1 C57BL/6N embryonic stem cells. A positive embryonic stem clone was subjected to the generation of chimera mice by injection using C57BL/6J blastocysts as the host. Successful germline transmission was confirmed by PCR sequencing. The heterozygous mice were bred to Actin-flpase mice [The Jackson Laboratory, B6.Cg-Tg (ACTFLPe)9205Dym/J] to remove the neo gene and make the Q293 knock-in mouse. Age- and gender-matched mice (2 – 6 month old, both male and female) were used for indicated experiments. WT/SAVI (male) x WT/HAQ (female), WT/SAVI (male) x WT/AQ (female) breeders were set up to generate HAQ/SAVI, AQ/SAVI mice. Mice were housed at 22°C under a 12‐h light‐dark cycle with ad libitum access to water and a chow diet (3.1 kcal/g, Teklad 2018, Envigo, Sommerset, NJ) and bred under pathogen-free conditions in the Animal Research Facility at the University of Florida. Littermates of the same sex were randomly assigned to experimental groups. All mouse experiments were performed by the regulations and approval of the Institutional Animal Care and Use Committee at the University of Florida, IACUC202200000058.
Aybar-Torres A., Saldarriaga L.A., Pham A.T., Emtiazjoo A.M., Sharma A.K., Bryant A.J, & Jin L. (2024). The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice. bioRxiv.
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10

Dietary Impacts on Wistar Rat Physiology

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Adult, male Wistar rats (n = 20; 200–224 g upon receipt; Envigo, Indianapolis, IN) were used exclusively to limit additional hormonal variability. Rats were randomized and remained on a standard laboratory diet (STD; Teklad 2018, 6.2% kcal from fat, 4.00 kcal/g; Envigo) or fed a Western HFD (HFD; 60% kcal from fat, 5.13 kcal/g; Research Diets, New Brunswick, NJ) beginning 1 week before assignment into the experimental groups in order to acclimate to the novel diet. Animals were initially housed 2 per cage on a 12-h light/dark cycle with food and water provided ad libitum and were housed singly with environmental enrichment after the first surgical procedure.
Holmes G.M., Willing L.B., Horvath N, & Hajnal A. (2022). Feasibility Study of Bariatric Surgery in a Rat Model of Spinal Cord Injury to Achieve Beneficial Body Weight Outcome. Neurotrauma Reports, 3(1), 292-298.
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