Aicar

Manufactured by Apexbio

Sourced in United States

AICAR is a chemical compound that acts as an AMPK activator. It is primarily used for research purposes in various scientific fields, including cell biology and biochemistry. AICAR's core function is to stimulate the AMP-activated protein kinase (AMPK) pathway, which plays a role in cellular energy metabolism.

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Lab products found in correlation

Anti srebp 1c sc 13551, by Santa Cruz Biotechnology (1 mentions) Ab2413, by Abcam (1 mentions) Ab34710, by Abcam (1 mentions) Ab23875, by Abcam (1 mentions) Ab126611, by Abcam (1 mentions) Ab50533, by Abcam (1 mentions) Ab131512, by Abcam (1 mentions) Sbi 0206965, by Merck Group (1 mentions) Anti lamin b 12987 1 ap, by Proteintech (1 mentions) Anti lc3b 3868, by Cell Signaling Technology (1 mentions)

2 protocols using aicar

AICAR Activates AMPK in KGN Cells

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AICAR was used as a pharmacological activator of AMPK, which was purchased from APExBIO (USA). KGN cells were treated with AICAR at the final concentration of 0.1 mM for 24 h to evaluate the effect of AMPK activation.

Li D., Wang X., Li G., Dang Y., Zhao S, & Qin Y. (2021). LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA. Cell Death Discovery, 7, 107.

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Investigating Adiponectin Receptor Signaling

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We used the following commercially available antibodies: The anti-AdipoR1 (ab126611), anti-FN (ab2413), anti-Collagen I (ab34710), anti-AMPKα1 + AMPKα2 (ab131512), anti-AMPK alpha 1 (phospho T183) + AMPK alpha 2 (phospho T172) (ab23875), anti-RAB7(ab50533) and anti-ADRP (ab52356) antibodies were from Abcam; the anti-phospho-AMPKα(Thr172) (2535), anti-mTOR(2972), anti-phospho-mTOR(Ser2448)(5536), anti-ULK1 (8054), anti-phospho-ULK1 (Ser555) (5869), anti-SQSTM1/p62(5114) and anti-LC3B (3868) antibodies were from Cell Signaling Technology; and the anti-SQSTM1/P62 (18420-1-AP), anti-LC3B (18725-1-AP), anti-Beclin1 (11306-1-AP), anti-ADRP (15294-1-AP), anti-ATG5 (10181-2-AP), anti-TFEB (13372-1-AP), anti-β-actin (60008-1-Ig), anti-GAPDH (60004-1-Ig) and anti-Lamin B(12987-1-AP) antibodies were from Proteintech. The anti-SREBP-1c(sc-13551) was from Santa Cruz Biotechnology. AdipoRon and CQ was obtained from Selleckchem. AICAR was provided by Apexbio Technology, SBI-0206965 was purchased from Sigma-Aldrich.

Han Y., Xiong S., Zhao H., Yang S., Yang M., Zhu X., Jiang N., Xiong X., Gao P., Wei L., Xiao Y, & Sun L. (2021). Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy. Cell Death & Disease, 12(11), 1031.

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