Biograph 16 hirez scanner

Manufactured by Siemens

Sourced in Germany

The Biograph 16 HiREZ scanner is a medical imaging device designed for positron emission tomography (PET) and computed tomography (CT) imaging. It is capable of capturing high-resolution images of the human body to assist in clinical diagnosis and research.

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Lab products found in correlation

Achieva 3t mri scanner, by Philips (1 mentions) 8 channel phased array head coil, by Philips (1 mentions)

Close spelling variants of this product

Hirez-Biograph 16 Biograph 16 scanner Biograph 16 Siemens scanners

4 protocols using biograph 16 hirez scanner

Phantom-based Evaluation of Attenuation Correction Methods

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To compare the effects of µ-map_MR and µ-map_CT in AC on PET data,
anthropomorphic numerical phantoms of the pelvis were generated from CT data (Figure 2) by simulating the average
18 F-fluoro-deoxy-glucose (FDG) uptake of a normal healthy patient.^{30 (link)} This procedure imitates the generation of emission phantoms from CT data as
described by Catana et al.^{22 (link)} The generated emission phantoms were smoothed using a 3-D Gaussian kernel with an
FWHM of 5 mm.
As shown in Figure 2, the
simulated PET data was converted to projection data (sinogram) and attenuated with
µ-map_CTref as the reference CT-derived µ-map and then mixed with Poisson
noise to generate PET raw data.^{18 (link)} The work simulated the geometry of the Biograph 16 Hi-REZ scanner (Siemens,
Germany) for generating PET raw data and photon attenuation. Note that the steps of
forward projection, photon attenuation, and AC were performed using an software for
Tomographic Image Reconstruction (STIR) package.^{31 (link)}

Shandiz M.S., Rad H.S., Ghafarian P., Yaghoubi K, & Ay M.R. (2018). Capturing Bone Signal in MRI of Pelvis, as a Large FOV Region, Using TWIST Sequence and Generating a 5-Class Attenuation Map for Prostate PET/MRI Imaging. Molecular Imaging, 17, 1536012118789314.

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Multimodal Neuroimaging of Brain Structure and Function

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Structural brain images were acquired on a Philips Achieva 3T MRI scanner equipped with an 8-channel phased-array head coil (Philips, Best, Netherlands). A whole-brain T1-weighted magnetization prepared rapid gradient echo (MPRAGE) was acquired with the following parameters: sagittal slice orientation, repetition time (TR) = 2300 ms, echo time (TE) = 4.5 ms, matrix = 320 × 320, flip angle = 8°, voxel resolution = 0.8 mm³ isotropic, no gap between slices, acquisition time = 9.1 min. Head motion was minimized by using a head restraint system and placing foam padding around the subject's head. Participants were provided with headphones and foam earplugs to attenuate scanner noise.
FDG-PET brain images were acquired on a whole-body PET-CT Siemens Biograph 16 HiREZ scanner (Siemens Medical Systems, Germany) in 3D mode. Subjects fasted for at least 8 h before PET examination, and they were scanned at the same time of the day (8:00-9:00 am). Participants were injected with 370 MBq of FDG in a quiet, dimly-lit room. FDG-PET images were acquired in static mode 30 min after injection with scan duration of 10 min. FDG brain scans were corrected for attenuation, scatter and decay, smoothed, and reconstructed with 2.6 x 2.6 x 2 mm voxel resolution using back-projection filters.

Cantero J.L., Atienza M., Ramos-Cejudo J., Fossati S., Wisniewski T, & Osorio R.S. (2020). Plasma tau predicts cerebral vulnerability in aging. Aging (Albany NY), 12(21), 21004-21022.

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FDG and Florbetaben PET Imaging Protocol

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PET examinations (2-[ 18 F]fluoro-2-deoxy-D-glucose-FDG-and Florbetaben) were performed in a whole-body PET-CT Siemens Biograph 16 HiREZ scanner (Siemens Medical Systems, Erlangen, Germany). FDG-PET imaging was first performed, followed by FBB-PET scans two weeks later. PET data were corrected for radioactive decay, dead time, attenuation, and scatter. PET brain images were reconstructed iteratively with an isotropic voxel resolution of 2 mm 3 .
Subjects fasted for at least 8 h before FDG-PET examination. Participants were injected with 185 MBq of FDG in a quiet, dimly lit room. FDG-PET images were acquired 30 min after injection with a scan duration of 10 min. For Aβ PET imaging, participants were injected with 300 MBq of [ 18 F]florbetaben (FBB) (NeuraCeq™, Piramal Pharma) 90 min before acquisition. Subjects underwent a 20-min FBB PET scan in dynamic mode consisting of 4 frames of 5 min each. Each frame was inspected for excessive motion. As excessive head motion was not detected in any scans, images from the four frames were averaged to create a single static FBB brain image used for quantitative analysis.

Palomar-Bonet M., Atienza M., Hernández-Ledesma B, & Cantero J.L. (2021). Associations of Salivary Total Antioxidant Capacity With Cortical Amyloid-Beta Burden, Cortical Glucose Uptake, and Cognitive Function in Normal Aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(10).

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FDG-PET/CT Imaging in Animal Models

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FDG-PET/CT scans were performed on a Biograph 16 HireZ scanner (Siemens Healthcare, Forchheim, Germany). All animals were fasted overnight before the scans. To reduce myocardial fatty acid metabolism and to stimulate insulin-dependent glucose uptake, plasma glucose levels were titrated using a hyperinsulinemic euglycemic clamping method as described previously. 17 (link) Thirty minutes after intravenous injection of 370 MBq (10 mCi) FDG, animals underwent a CT scan for attenuation correction and a 30-minute PET emission scan. During all acquisitions, ECG and breathing (thoracic belt) information was recorded for later motion correction.

Duchenne J., Turco A., Ünlü S., Pagourelias E.D., Vunckx K., Degtiarova G., Bézy S., Cvijic M., Nuyts J., Claus P., Rega F., Gheysens O, & Voigt J.U. (2019). Left Ventricular Remodeling Results in Homogenization of Myocardial Work Distribution. Circulation. Arrhythmia and electrophysiology, 12(5).

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