Sprague dawley rats

Manufactured by Japan SLC

Sourced in Japan

Sprague-Dawley rats are a commonly used laboratory animal model. They are a breed of albino rats developed for use in scientific research. Sprague-Dawley rats are known for their calm temperament and reliable breeding characteristics, making them a widely accepted choice for various experimental studies.

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Lab products found in correlation

C57bl 6j mice, by Japan SLC (3 mentions) Clea rodent diet ce 2, by CLEA Japan (2 mentions) Wild type c57bl 6 mice, by Japan SLC (2 mentions) Streptozotocin (stz), by Merck Group (2 mentions) Cd 1 mice, by Japan SLC (2 mentions) Sod assay kit wst, by Dojindo Laboratories (2 mentions) Glutamax, by Thermo Fisher Scientific (2 mentions) Glutathione (gsh), by Fujifilm (2 mentions) Isoflurane, by Fujifilm (2 mentions) Metaphosphoric acid, by Fujifilm (2 mentions) Sodium selenite, by Fujifilm (2 mentions) 3 aminopropionitrile, by Tokyo Chemical Industry (1 mentions) Ddy mice, by Japan SLC (1 mentions) Balb c mice, by Japan SLC (1 mentions) Bs 300cp, by EXAKT (1 mentions) Standard diet, by CLEA Japan (1 mentions) α mem, by Nacalai Tesque (1 mentions) Alexa fluor 488 conjugated wheat germ agglutinin, by Thermo Fisher Scientific (1 mentions) Lipopolysaccharide lps, by Merck Group (1 mentions) Hydrocortisone, by Merck Group (1 mentions)

Close spelling variants of this product

Male Sprague-Dawley rats (71 citations) Female Sprague Dawley rats (6 citations)

115 protocols using sprague dawley rats

Ovalbumin-Induced Allergy Model in Rats

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Sixty-six male Sprague-Dawley rats weighing 370±8 g (Japan SLC, Shizuoka, Japan) were maintained at 23°C and under pathogen-free conditions on a 12:12-h dark/light cycle and allowed food and water ad libitum. The present experiments were conducted according to the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised in 1978) and approved by the Animal Research Committee of Kanazawa Medical University (2016–51). Rats were divided into two groups of the shock and control groups: the shock group animals were sensitized with subcutaneous injections of ovalbumin antigen (1 mg, 0.5 ml) and complete Freund’s adjuvant (0.5 ml), as described previously [15 (link), 16 (link)], while the control group animals were injected with adjuvant only without ovalbumin. Two weeks after injection, rats were used for the following experiments.
All drugs were purchased from Sigma Chemical Company (St Louis, MO, USA) and were dissolved in saline. The lot number of the ovalbumin was SLBQ9036V.

Zhang T., Shibamoto T., Tanida M., Taniguchi M., Kuda Y., Yang W, & Kurata Y. (2020). Angiopoietin-2 is released during anaphylactic hypotension in anesthetized and unanesthetized rats. PLoS ONE, 15(11), e0242026.

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Sprague-Dawley Rat Housing and Care

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10- to 12-week-old female Sprague–Dawley rats (190–250 g) purchased from Japan SLC (Shizuoka, Japan) were housed at a constant temperature of 23 °C and 50–60% humidity under a regular 12-h light/dark schedule at the University of Fukui Animal Center. Tap water and standard rat chow were freely available. All animal experiments were conducted according to Fukui University’s Animal Care and Use Committee guidelines, and all experimental protocols were approved by the Fukui University Ethics Commission (number R02059). This study was carried out in compliance with the ARRIVE guidelines.

Oe H., Yoshiki H., Zha X., Kobayashi H., Aoki Y., Ito H, & Yokoyama O. (2021). Urinary reabsorption in the rat kidney by anticholinergics. Scientific Reports, 11, 9191.

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Rat Rotator Cuff Tear Model

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Ninety-six adult (12-week-old) Sprague–Dawley rats (Japan SLC Inc., Hamamatsu, Shizuoka, 380–460 g) were used in this study. The rats were divided into two groups according to the method of evaluation, which included imaging or histologic examination. The following three RCT types were created on the left side, with an equal number of animals in each group: anterior group, subscapularis tear only; anterosuperior group, subscapularis, supraspinatus, and infraspinatus tear; superior group, supraspinatus and infraspinatus tear; and control group, no tear. Group classifications are shown in Fig. 1.Fig. 1

Group classification

Kajiwara D., Ochiai N., Hashimoto E., Hirosawa N., Akimoto K., Nojima D., Shimada Y., Ise S, & Ohtori S. (2023). Imaging and histological evaluation of the long head of the biceps tendon in the presence of different types of rotator cuff tears. BMC Musculoskeletal Disorders, 24, 230.

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Evaluation of SOKT and Duloxetine on Neuropathic Pain

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Animals Six-week old male Sprague-Dawley rats (200-250 g, Japan SLC, Inc., Shizuoka, Japan) were divided into groups of four rats per cage and kept under lights from 7:00 to 19:00. ) or a vehicle (saline) was treated on the same schedule. To determine the effects of SOKT and duloxetine on paclitaxel and bortezomib-induced mechanical allodynia, the tests were performed on days 12 and 13. SOKT extract (0.3 or 1.0 g/kg), duloxetine hydrochloride (30 mg/kg) or a vehicle (distilled water) was treated orally, and behavioral tests were assessed immediately before and 30-120 min after drug treatment. The clinical dose of SOKT is about 0.1 g/kg/d in human. Considering species differences, 0.3 and 1 g/kg were used. For reference, 0.3 and 1 g/kg of Goshajinkigan have been used in animal studies, 4, (link)5) (link) although the clinical dose of it is also about 0.1 g/kg/d.

Nakamura H., Kawashiri T., Kobayashi D., Uchida M., Egashira N, & Shimazoe T. (2021). Analgesic Effects of Sokeikakketsuto on Chemotherapy-Induced Mechanical Allodynia and Cold Hyperalgesia in Rats. Biological & pharmaceutical bulletin, 44(2).

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Sprague–Dawley Rat Housing and Care

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Eight‐week‐old male Sprague–Dawley rats (weight, 240–280 g) were purchased from Japan SLC, Inc. (Shizuoka, Japan). All animals were housed in polycarbonate cages in a room with controlled conditions of ambient temperature (23 ± 3 °C), humidity (50 ± 20%), and lighting (12‐h light : dark cycle). Animals were maintained with water and standard laboratory food ad libitum. Access to standard laboratory food was removed 16 h before experiments. All experimental procedures were performed according to the Guidelines for the Care and Use of Laboratory Animals and approved by the Laboratory Animal Committee (Permit nos. 10‐113, 10‐139, 11‐031, 11‐046, 13‐080, and 14‐008) of Tsumura & Co. (Tokyo, Japan).

Harada Y., Ro S., Ochiai M., Hayashi K., Hosomi E., Fujitsuka N., Hattori T, & Yakabi K. (2015). Ghrelin enhancer, rikkunshito, improves postprandial gastric motor dysfunction in an experimental stress model. Neurogastroenterology and Motility, 27(8), 1089-1097.

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Sprague Dawley Rat Model for Pharmacological Evaluation

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Thirty-seven adult male Sprague Dawley rats (10 weeks old) weighing 330–350 g were purchased from Japan SLC, Inc. (Hamamatsu, Japan) and housed under a temperature- (23 ± 0.5 °C) and humidity- (55 ± 10%) controlled environment with a 12/12 h light–dark cycle. The rats were provided with standard rodent chow (CE-2, CLEA Japan, Inc., Tokyo, Japan) and water ad libitum. All rats were acclimated to the environment for 1 week. FA and FAD012 were dissolved in saline containing 0.5% carboxymethyl cellulose and prepared at the time of use (Figure 1). All experiments were performed in compliance with the Guiding Principles for the Care and Use of Laboratory Animals approved by the Japanese Pharmacological Society, and the guidelines were approved by the Ethics Committee on Animal Care and Animal Experimentation at Josai University (approval number H28094, H29063, JU18060). The number of animals used was carefully estimated and kept to the minimum necessary for meaningful interpretation of the data. Animal discomfort was also minimized.

Asano T., Xuan M., Iwata N., Takayama J., Hayashi K., Kato Y., Aoyama T., Sugo H., Matsuzaki H., Yuan B., Kamiuchi S., Hibino Y., Sakamoto T, & Okazaki M. (2023). Involvement of the Restoration of Cerebral Blood Flow and Maintenance of eNOS Expression in the Prophylactic Protective Effect of the Novel Ferulic Acid Derivative FAD012 against Ischemia/Reperfusion Injuries in Rats. International Journal of Molecular Sciences, 24(11), 9663.

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Sprague-Dawley Rat Housing and Handling

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All Sprague-Dawley rats (male, 8 weeks of age or retired; Japan SLC, Inc) were housed in a conventional room with 12-hour light-dark cycles. All experiments conducted in this study were reviewed and approved by the institutional Animal Care and Use Committee (Approval #: 2015-P-026). The handling and care of the rats were done according to the National Institutes of Health guidelines. All surgical procedures for rats were performed under isoflurane anesthesia.

Tokuno M., Taguchi K., Sakai H., Ohtsuki S., Yamasaki K, & Otagiri M. (2020). Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles. Drug Metabolism and Pharmacokinetics, 35(5), 417-424.

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Sprague-Dawley Rat Model for Hypoxia Study

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A total of 30 5-week-old male Sprague-Dawley rats weighing 130-150 g were purchased from Japan SLC (Shizuoka, Japan). All rats were housed in the animal experimental facility of Chiba University and had free access to drinking water and food. The rats were kept at 24°C under a 12 h light/dark cycle in the animal experimental facility of Chiba University as described previously (16 (link)). All animal procedures were approved by the Review Board for Animal Experiments of Chiba University (approval no. 30-126) and were performed in accordance with the guidelines of the Animal Research Committee of Laboratory Animal Center, Graduate School of Medicine, Chiba University (17 ). The rats were divided into three groups (n= 10 rats per group) as follows: i) Untreated control (CTRL); ii) Su/Hx + vehicle (PBS) and iii) Su/Hx + CH administration (Fig. 1).

Kobayashi T., Kim J.D., Naito A., Yanagisawa A., Jujo-Sanada T., Kasuya Y., Nakagawa Y., Sakao S., Tatsumi K, & Suzuki T. (2022). Multi-omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin. International Journal of Molecular Medicine, 49(5), 69.

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Carotid Artery Bifurcation Model in Rats

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Seven-week-old male Sprague-Dawley rats were purchased from Japan SLC (Shizuoka, Japan). Rats were maintained on a light/dark cycle of 12 h/12 h and had free access to chow and water. Under general anesthesia by the inhalation of isoflurane (induction; 5.0 %, maintenance; 1.5~2.0 %), the left common carotid artery (CCA) was cut in the proximal portion and moved to the right side [33, 34] . The left CCA was then anastomosed to the right CCA in an end-to-side fashion with a 10-0 nylon suture to create a bifurcation. Hyper-volemic state was also induced by salt overloading and ligation of the left renal artery. Immediately after the above surgical manipulations, animals were fed the chow containing 8 % sodium chloride and 0.12 % 3-aminopropionitrile (Tokyo Chemical Industry, Tokyo, Japan), an inhibitor of lysyl oxidase that catalyzes the crosslinking of collagen and elastin, which facilitates degenerative changes of arterial walls.

Okada A., Koseki H., Ono I., Kayahara T., Kurita H., Miyamoto S., Kataoka H, & Aoki T. (2022). Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 31(12).

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Fasting Protocols for Rodent Studies

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Animal experiments were performed at Kobe Gakuin University and complied with the regulations of the Committee on Ethics in the Care and Use of Laboratory Animals (approved as A16-15 and A17-4). Male Sprague Dawley rats weighing 180–220 g and male ddY mice weighing 30–40 g were purchased from Japan SLC, Inc. (Shizuoka, Japan), housed in temperature controlled rooms (23 ± 1 °C) with a relative humidity of 55 ± 5% and had free access to water and food during acclimatization. Animals were fasted for 18 h (rats) and 24 h (mice) before the experiments; however, they were allowed to drink water ad libitum.

Kamei N., Tamiwa H., Miyata M., Haruna Y., Matsumura K., Ogino H., Hirano S., Higashiyama K, & Takeda-Morishita M. (2018). Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals. Pharmaceutics, 10(4), 182.

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