Dimethyl acetylenedicarboxylate

Manufactured by Merck Group

Dimethyl acetylenedicarboxylate is a chemical compound used as a laboratory reagent. It is a colorless crystalline solid with the molecular formula C₆H₈O₄. The compound serves as a precursor for the synthesis of various organic compounds and is widely utilized in chemical research and development.

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Lab products found in correlation

Potassium bromide, by Thermo Fisher Scientific (1 mentions) Methyl tert butyl ether (mtbe), by Thermo Fisher Scientific (1 mentions) Anhydrous dichloromethane dcm, by Merck Group (1 mentions) Diethyl ether et2o, by Thermo Fisher Scientific (1 mentions) Tetrahydrofuran thf, by Merck Group (1 mentions) Polyphosphoric acid, by Merck Group (1 mentions) Tert butyl bromoacetate, by Merck Group (1 mentions) Dry solvents, by Merck Group (1 mentions) 2 nitroaniline, by Merck Group (1 mentions) Dioleoylphosphatidylcholine dopc, by Avanti Polar Lipids (1 mentions) Dioleoylphosphatidylglycerol dopg, by Avanti Polar Lipids (1 mentions)

2 protocols using dimethyl acetylenedicarboxylate

Synthesis of Organic Compounds Using Common Reagents

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Anhydrous dichloromethane (DCM) and tetrahydrofuran (THF) were purchased from Sigma Aldrich. Absolute ethanol was obtained from Decon Laboratories. Diethyl ether (Et₂O), methyl tert‐butyl ether (MTBE), and sodium azide were purchased from Fisher Scientific. Triethylamine (NEt₃) and methanesulfonyl chloride (MsCl) were obtained from Acros and distilled from CaH₂ and P₂O₅, respectively. Trifluoroacetic acid (TFA) was purchased from Oakwood Products. Pearlman's catalyst (Pd(OH)₂/C), 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO), phenylacetylene (PA), diphenylacetylene (DPA), dimethyl acetylenedicarboxylate (DMAD), and diethyl acetylenedicarboxylate (DEBD) were purchased from Sigma Aldrich and used as received. Potassium bromide and di‐tert‐butyl dicarbonate ((Boc)₂O) were purchased from Acros and used as received.

Edward Semple J., Sullivan B., Vojkovsky T, & Sill K.N. (2016). Synthesis and facile end‐group quantification of functionalized PEG azides. Journal of Polymer Science. Part A, Polymer Chemistry, 54(18), 2888-2895.

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Fluorescent Dye Binding Assay

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ThT was purchased from Acros Organics (Fair Lawn, New Jersey). Lipids [dioleoylphosphatidylglycerol (DOPG) and dioleoylphosphatidylcholine (DOPC)] were purchased from Avanti Polar Lipids, Inc. (Alabaster, Al). The 96-well plates (coated, non-binding surface, black, flat bottom) were bought from Greiner Bio-One (Monroe, NC). All of the chemicals were purchased from commercial suppliers and used without further purification. Silica plates (w/UV254, aluminum backed, 200 micron) and silica gel (standard grade, particle size = 40–63 micron, 230 × 400 mesh) for flash column chromatography were purchased from Sorbent Technologies (Atlanta, GA). Dry solvents were purchased from Sigma Aldrich (St. Louis, MI) or VWR (Bridgeport, NJ). Triethylamine (dry), 2-chloro-1-methylpyridinium iodide, tert-Butyl bromoacetate, 2-nitroaniline, dimethylacetylene dicarboxylate, and polyphosphoric acid were purchased from Sigma Aldrich (St. Louis, MI).

Kumar S., Brown M.A., Nath A, & Miranker A.D. (2014). Folded Small Molecule Manipulation of Islet Amyloid Polypeptide. Chemistry & biology, 21(6), 775-781.

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