After environmental adaption for one week, the rats were assigned to one of the following groups according to their sucrose preference ratio and body weight: normal control group (only saline treatment and no chronic unpredictable stress (CUS)); CUS depression group (saline treatment and CUS); paroxetine group (1.8 mg/kg, GlaxoSmithKline, England, paroxetine treatment group and CUS); HJDT groups (2, 4, and 8 g/kg, HJDT treatment and CUS). Rats were given intragastrically either paroxetine, HJDT, or saline for 42 days after the CUS, and at 1 h before the beginning of the CUS procedure or behavioral tests. The dose of paroxetine and HJDT were chosen based on the previous reports [7 (link), 17 (link)].
Paroxetine
Manufactured by GlaxoSmithKline
Sourced in United Kingdom
Paroxetine is a selective serotonin reuptake inhibitor (SSRI) medication. It is a lab equipment product used in the research and development of pharmaceutical drugs.
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Lab products found in correlation
4 protocols using paroxetine
1
Antidepressant Effects of HJDT in Rats
2
Individual Patient Data Analysis of SSRI/SNRI Trials for Anxiety Disorders
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We requested IPD from Clinical Study Data Request (CSDR, https://clinicalstudydatarequest.com ). We first identified all selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) developed by participating sponsors. These were paroxetine (GlaxoSmithKline), fluoxetine (Lilly), and duloxetine (Lilly). Although other SSRIs and SNRIs are also used for anxiety disorders, these were not available through CSDR. We then identified all double‐blind, placebo‐controlled, and short‐term (≤16 weeks) randomized controlled trials (RCTs) of these antidepressants for an anxiety disorder, OCD, or PTSD in adults that were mentioned in Food and Drug Administration (FDA) drug approval packages (Roest et al., 2015 ) or the GlaxoSmithKline (https://www.gsk-clinicalstudyregister.com ) and Lilly (https://www.lilly.com/clinical-study-report-csr-synopses ) trial registries.
3
Placebo-Controlled Trials for Major Depression
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Patient-level data from 28 industry-sponsored, placebo-controlled, acute phase trials for adults with major depression using the HDRS-17 as symptom inventory were obtained for citalopram (Lundbeck, Valby, Denmark), paroxetine (GlaxoSmithKline, Brentford, UK) and sertraline (Pfizer, New York, NY, USA). In two of the paroxetine studies and one sertraline study, fluoxetine was used as active control; while these patients were also included, those treated with non-SSRI comparators were not. To corroborate results obtained using data from the SSRI trials, we also analysed patient-level data from 13 trials comparing duloxetine to placebo (Lilly, Indianapolis, IN, USA). SSRI comparators (escitalopram, fluoxetine and paroxetine) were excluded. Both these data sets have been previously described in greater detail [7 , 8 (link)].
4
Formulation and Evaluation of Paroxetine Orally Disintegrating Tablets
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Paroxetine (PX) was provided by Glaxosmithkline Beecham, England. Pectin was purchased from Alpha Chemika (Mumbai, India). Carboxymethyl cellulose (CMC) was provided by Dow Wolff Cellulosics (Bomlitz, Germany). Poloxamer 188, citric acid, menthol, and Tween 80 were provided by Sigma Aldrich Co. (St. Louis, MO, USA). Polyethylene glycol 400 (PEG 400), glycerol, and Propylene glycol (PG) were obtained from Prolabo Co. (Paris, France). Sucralose was from El- Gomhouria Chemical Co. (Cairo, Egypt). Paroxetine® 25 mg oral market tablets were from EVA Pharma Co., (Cairo, Egypt). The rest of the solvents and chemicals were of analytical grade.
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