Pearl scope software

Manufactured by Thermo Fisher Scientific

The Pearl Scope software is a tool designed for analyzing and visualizing data from Thermo Fisher Scientific's Pearl imaging systems. It provides users with the ability to process and view images and videos captured by the Pearl instruments.

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Lab products found in correlation

Excelsior es tissue processor, by Thermo Fisher Scientific (2 mentions) Shandon finesse 325 manual microtome, by Thermo Fisher Scientific (2 mentions) Evos fl auto microscope, by Thermo Fisher Scientific (2 mentions) Hematoxylin, by Thermo Fisher Scientific (1 mentions) Origin 2017, by OriginLab (1 mentions) Buffered formalin, by Thermo Fisher Scientific (1 mentions)

2 protocols using pearl scope software

Histological Assessment of Tissue Inflammation

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Tissues were excised and immediately placed in 10% buffered formalin (Fisher) for at least 48 h to ensure enough penetration, then processed with Excelsior ES tissue Processor (Thermo). Tissues were embedded in paraffin blocks and 4 μm sections were cut with Shandon Finesse 325 Manual Microtome (Thermo). Slides were stained with hematoxylin and eosin (both from Fisher) according to a standard protocol. Slides were analyzed by an experienced clinical pathologist (N.S.) in a blinded manner. At least three fragments of each tissue were photographed (EVOS FL Auto microscope (×10 magnification) equipped with Pearl Scope software (Fisher). Scale 0-4 was applied: 0-no inflammation (no discernible inflammation), 1-mild (small, focal focus of inflammation), 2-moderate (small, multiple foci of inflammation), 3-strong (multiple large foci of inflammation), and 4- severe (significant inflammation with parenchymal destruction). Data were analyzed with Origin 2017 (OriginLab).

Cebula A., Kuczma M., Szurek E., Pietrzak M., Savage N., Elhefnawy W.R., Rempala G., Kraj P, & Ignatowicz L. (2019). Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice. Nature Communications, 10, 4882.

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Histological Assessment of Colitis

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Tissues were excised and placed in 10% buffered formalin (Fisher Scientific) for 24 hours and processed with Excelsior ES tissue Processor (Thermo). Tissues were embedded in paraffin blocks, and 4-μm sections were cut with Shandon Finesse 325 Manual Microtome (Thermo). Slides were stained with hematoxylin and eosin (H&E) (Fisher Scientific) according to a standard protocol. Three fragments of each tissue were photographed [EVOS FL Auto microscope (×40 magnification) equipped with Pearl Scope Software (Fisher Scientific)], and average colitis scores (0, no discernible inflammation; 1, small, focal focus of inflammation; 2, small, multiple foci of inflammation; 3, multiple large foci of inflammation; and 4, significant inflammation with parenchymal destruction) were calculated.

Kuczma M.P., Szurek E.A., Cebula A., Chassaing B., Jung Y.J., Kang S.M., Fox J.G., Stecher B, & Ignatowicz L. (2020). Commensal epitopes drive differentiation of colonic Tregs. Science Advances, 6(16), eaaz3186.

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