Oncentra

Manufactured by Elekta

Sourced in Sweden

Oncentra is a comprehensive treatment planning system designed for radiation therapy. It provides a platform for the planning, preparation, and delivery of radiotherapy treatments. Oncentra offers advanced tools and features for efficient and accurate treatment planning, without interpretation or extrapolation on its intended use.

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Lab products found in correlation

Brilliance big bore ct scanner, by Philips (1 mentions) Spss statistics version 21, by IBM (1 mentions) Primus hi, by Siemens (1 mentions) Pinnacle3 9, by Philips (1 mentions)

Close spelling variants of this product

Oncentra Treatment Planning System, version 4.3 Oncentra External Beam Oncentra MasterPlan Oncentra Brachy

14 protocols using oncentra

Radiation Therapy for Locally Advanced Cervical Carcinoma

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A total of 20 patients with locally advanced cervical carcinoma were selected for this planning study. These patients were randomly enrolled in this study between 2019 and 2020 in the department. Age ranged from 46 to 64 years, with a median age of 50 years. According to the International Federation of Gynecology and Obstetrics, [ 9 ] the clinical stage was as follows: stage IIA, five patients (25%) and Stage IIB, 15 patients (75%).
All the patients received a planning computed tomography (CT) scan (Brilliance Big Bore CT scanner, Philips Healthcare, Cleveland, OH, USA) in a supine treatment position with arms elevated above the head. CT images were reconstructed using a 0.3 cm thickness. Each patient's images were sent for contouring (Oncentra, Elekta AB, Stockholm, Sweden) and planning (HT, Tomotherapy Inc., Madison, WI, USA). The clinical target volume (CTV) was contoured according to the Radiation Therapy Oncology Group reports.[ 10 ] The CTV was defined as the cervix, uterus, upper half of the vagina, and pelvic lymph nodes. The planning target volume (PTV) was defined as the CTV plus 0.5-1.0 cm margins. The OARs include the rectum, bladder, intestine, spinal cord, bone, and femoral head. The mean volume of the CTV was 700.6 ± 40.6 cm 3 (range, 529.5-895.2 cm 3 ), and PTV was 1272.6 ± 60.2 cm 3 (range, 1020.8-1596.6 cm 3 ).

Wu J., Liu X., Wang P., Li J., Wu F., Tang B, & Kang S. (2021). Dosimetric and delivery comparison of helical tomotherapy with dynamic jaw and fixed jaw for cervical carcinoma. Journal of cancer research and therapeutics, 17(7).

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Intraoperative Ultrasound-Guided HDR-BT

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HDR-BT was performed using intra-operative real time 3D ultrasound planning with Oncentra (Elekta AB, Stockholm, Sweden). A standardised template-based catheter configuration was used, and dwell time optimization performed using ultrasound. The Clinical Target Volume (CTV) was defined as the prostate capsule plus any macroscopic extracapsular disease or SV involvement identified on diagnostic images expanded by 3 mm to encompass potential microscopic disease. The CTV was used as the PTV.

Crowther K., Cole A., Shiels P., Jain S., Shepherd P, & Mitchell D. (2019). A pilot study of patient reported outcomes evaluating treatment related symptoms and quality of life for men receiving high dose rate brachytherapy combined with hypo-fractionated radiotherapy or hypo-fractionated radiotherapy alone for the treatment of localised prostate cancer. Technical Innovations & Patient Support in Radiation Oncology, 9, 18-25.

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Radiation Exposure of Hippocampi in GBM Patients

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The cohort consists of 61 GBM patients who were treated for the first time with radio(−chemo-) therapy at the University hospital of Munich, Department of Radiation Oncology in 2011. All patients had a histologically and radiologically (using magnetic resonance imaging (MRI) with contrast media) proven GBM and had a treatment plan based on Oncentra® (by Elekta, Stockholm, Sweden). The contours of the patients’ hippocampi were outlined directly in the Oncentra® cases in order to retrospectively determine its radiation exposure. Some patients’ hippocampi could not be located in their entirety due to the size and location of the tumor. For these patients, the hippocampus on the tumor’s side was left out partly or entirely, thus only leaving the contralateral side to be contoured. The statistical data were analyzed with IBM SPSS Statistics® Version 21.

Bodensohn R., Söhn M., Ganswindt U., Schupp G., Nachbichler S.B., Schnell O., Belka C, & Niyazi M. (2014). Hippocampal EUD in primarily irradiated glioblastoma patients. Radiation Oncology (London, England), 9, 276.

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3D Printed Phantoms for Dosimetry Verification

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A 4x4x7 cm³ ABS block was 3D printed using a commercially available 3D printer (Taz 6, Aleph Objects Inc., Loveland, CO) with 100% infill and a 0.2 mm layer height. The center of the catheter channel was offset by 1 cm from midline with the film placed along the surface of the block 3 cm from the catheter (see Figs. 2, 3 and 4). The treatment planning software (Oncentra, Elekta, Stockholm, Sweden) was again used to measure dose to water ranging 50–800 cGy to the film. This procedure was repeated for a similar block made of PLA. ABS and PLA were assumed to be near water equivalent in the treatment planning system (TPS) [6 ].Fig. 2

A 3D printed ABS block, 4x4x7 cm³, with catheter placement 3 cm from base

Fig. 3

Film is placed 3 cm from the catheter and source, below the 3D printed block

Fig. 4

The 3D printed block, and film are surrounded by solid water to create scatter

Oare C., Wilke C., Ehler E., Mathew D., Sterling D, & Ferreira C. (2019). Dose calibration of Gafchromic EBT3 film for Ir-192 brachytherapy source using 3D-printed PLA and ABS plastics. 3D Printing in Medicine, 5, 3.

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Left-Sided Modified Radical Mastectomy and Adjuvant Radiotherapy

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All 25 patients enrolled in the prospective study underwent left-sided modified radical mastectomy and chemotherapy as per initial protocol. On completion of chemotherapy, postoperative irradiation was initiated within 3-4 weeks. The patients underwent CT simulation, and the CT images acquired were uploaded on treatment planning system (TPS) (Oncentra, version 4.3, Elekta). EBRT planning was done and the radiation treatment was delivered to the chest wall (left) using standard opposing medial and lateral tangential fields, and a single anterior field was used to treat the supraclavicular fossa (in patients requiring supraclavicular nodal irradiation) using 6 MV photons on linear accelerator (Primus HI, Siemens) machine to a total dose of 50 Gy in week, and for 5-6 weeks.

Taneja S., Mukherjee D., & Tyagi K. (2020). Patient setup variations in computed tomography-based treatment planning for left-sided breast cancer using electronic portal images. Journal of Marine Medical Society, 22(1), 30-30.

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Brachytherapy Boost for Head and Neck Cancer

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All patients in this study who were treated with brachytherapy received external beam radiotherapy to 68 Gy (as described above) followed by brachytherapy, which was given as a boost to the primary tumour with a safety margin of 5–10 mm, approximately one week after completion of the external beam radiotherapy. Implantation of catheters was done under general anaesthesia in an operating theatre by a radiation oncologist specialized in head and neck brachytherapy in collaboration with an ear, nose and throat surgeon. The technique used is the same as in Centre Alexis Vautrin in Nancy, France, described in an article by Pernot et al. [23 (link)]. The typical treatment (94% of patients receiving a brachytherapy boost) was a brachytherapy boost using pulsed dose rate (PDR) consisting of 15 fractions, 0.56–0.66 Gy per fraction [total dose in EQD2 = 75.4–76.8 Gy (α/β = 10)], delivered every hour during office hours, over a total time of 2–3 days (Fig. 1c). Seven patients (5%) received high dose rate brachytherapy (HDR) by clinician’s choice. All brachytherapy was delivered using an afterloading device and treatments were planned in Oncentra (Elekta, Sweden). A detailed list of all fractionation schedules used is supplied in the Additional file 1 (Table S1).
All doses reported in this study are prescribed doses.

Embring A., Onjukka E., Mercke C., Lax I., Berglund A, & Friesland S. (2023). Dose escalation in oropharyngeal cancer: a comparison of simultaneous integrated boost and brachytherapy boost. Radiation Oncology (London, England), 18, 65.

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IMRT for Whole Breast Irradiation

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Ten patients (mean 41 years old, range: 34–46) who underwent BCS for breast cancer were enrolled. Six of right and four of left breast. All patients diagnosed pT_1‐2 N₀M₀ would accept whole breast irradiation. Patients underwent simulation by 16‐slice CT (Brilliance; Philips Amsterdam, the Netherlands) in the supine position free breathing with contiguous slices (thickness, 5 mm). The Posirest two‐arm support (Civco Medical Solutions, Kalona, IA, USA) combined with a vacuum (Figure 2) was used for patient setup. The delineation of target volume was segmented in the treatment planning system (Oncentra; Elekta) and used as the reference for CBCT. Area of interest, such as CTV, and organ at risk (OARs) (ipsilateral lung and heart) were defined. The CTV was defined as the entire breast tissue starting 5 mm below the skin. The PTV was defined by adding a 5‐mm margin to the CTV except the direction of the skin. IMRT using four fields to a total prescribing dose of 46 Gy in 23 fractionations was implemented in all cases. Subsequently, all patients received an electron‐boost dose of 14 Gy in seven fractionations to the surgical bed.

Jiang P., Liu Z., Jiang W., Qu A., Sun H, & Wang J. (2022). Detection of setup errors with a body‐surface laser‐scanning system for whole‐breast irradiation after breast‐conserving surgery. Journal of Applied Clinical Medical Physics, 23(5), e13578.

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Brachytherapy Protocol for Gynecological Cancers

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All brachytherapy plans were generated using the Oncentra (Elekta, Stockholm, Sweden, version 4.6) treatment planning system according to the OAR dose constraints and HR‐CTV prescribed dose recommended by the American Brachytherapy Society (ABS)⁵⁰ and GEC‐ESTRO⁵⁰, ⁵¹, ⁵² guidelines. Assuming α/β = 10, a prescribed dose (EB + brachy) of D₉₀ > 80 Gy_EQD2 for the HR‐CTV and assuming an α/β = 3, the maximum dose (D_2cc) to the bladder and rectum (EB + brachy) of 90 Gy_EQD2 and 75 Gy_EQD2 respectively. To evaluate the dosimetric differences between the manual contours and predicted contours, the predicted segmentations were converted to DICOM before importing into the planning system and the original dose distribution was overlaid and cumulative dose volume histograms (DVHs) generated. The Dosimetric discrepancies of D_90% for HR‐CTV and D_2cc for the OARS were evaluated and compared with the DVH statistics generated from the manual contours.

Duprez D., Trauernicht C., Simonds H, & Williams O. (2023). Self‐configuring nnU‐Net for automatic delineation of the organs at risk and target in high‐dose rate cervical brachytherapy, a low/middle‐income country's experience. Journal of Applied Clinical Medical Physics, 24(8), e13988.

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Rectal Dose Evaluation in CBCT-guided Radiotherapy

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In each patient, eight CBCT-scans (slice thickness 2 mm) obtained at fraction number 1, 6, 11, 16, 21, 26, 31 and 36 (CBCT1-8) were transferred to the Oncentra© (Elekta AB, Stockholm, Sweden) treatment planning system. The RV was manually outlined on the planning CT (CT1) and CBCT1-8, resulting in 9 rectum contours for each patient (270 in total for all 30 patients). One Clinical Oncologist (HT) outlined the RVs including the outer wall from the recto-sigmoid transition to the caudal part of the anus on all CBCTs, and the RVs (cm³) were calculated automatically. The eight rectum contours obtained from each patient were imported and merged with CT1 using the prostatic fiducial gold markers as reference. Recalculation of rectal dose was done for each CBCT1-8 using CT1 and set up beams. Dose-volume histograms (DVHs) for RVs receiving 50, 60, 65, and 70 Gy (V50Gy, V60Gy, V65Gy and V70Gy) were software estimated, both in cm³ and in percentage of irradiated RV.

Tøndel H., Solberg A., Lydersen S., Jensen C.A., Kaasa S, & Lund J.Å. (2019). Rectal volume variations and estimated rectal dose during 8 weeks of image-guided radical 3D conformal external beam radiotherapy for prostate cancer. Clinical and Translational Radiation Oncology, 15, 113-117.

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3D Brachytherapy Imaging Protocol Analysis

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We retrospectively studied 70 patients who completed CT-based 3D brachytherapy. All patients used a CT/magnetic resonance imaging (MRI) Fletcher applicator (Elekta part # 189.730). The resolution of CT images was 1 mm × 1 mm, and the slice thickness was 3 mm. The number of CT slices was 69 to 100 (average, 87). The 70 patients were divided into training data, validation data, and test data according to the ratio of 50 : 10 : 10. The annotating of applicator was performed by an experienced physicist using Oncentra (Elekta AB, Stockholm, Sweden, version 4.3) treatment planning system. The tandem diameter of CT/MRI Fletcher applicator was 4 mm, and the inner lumen of tandem was about 2 mm, so the applicator from the middle of each channel was annotated and depicted in a circle with a 2 mm radius. The number of CT slices containing mask images (ground truth) was from 38 to 71, and the average number of slices for training data and validation data was 58 and 56, respectively.

Hu H., Yang Q., Li J., Wang P., Tang B., Wang X, & Lang J. (2021). Deep learning applications in automatic segmentation and reconstruction in CT-based cervix brachytherapy. Journal of Contemporary Brachytherapy, 13(3), 325-330.

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