1 β d ribofuranosyl 1 2 4 triazole 3 carboxamide

Manufactured by Merck Group

Sourced in United States

1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is a chemical compound. It is a synthetic nucleoside analog that exhibits antiviral properties.

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Lab products found in correlation

Ribavirin, by Merck Group (2 mentions) Milli q h2o, by Merck Group (1 mentions) Sofosbuvir, by MedChemExpress (1 mentions)

Close spelling variants of this product

Triazole (2 citations)

2 protocols using 1 β d ribofuranosyl 1 2 4 triazole 3 carboxamide

Synthesis and Preparation of 6MMPr and Ribavirin

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6-methylmercaptopurine riboside (6MMPr) (Fig. 1) and 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) were purchased from Sigma-Aldrich (Saint Louis, USA). ribavirin (RIB) was used as the positive control. Stock solutions of the compounds were prepared in Milli-Q H₂O and sterilized by filtering through a Millipore 0.22 μM filter. All stock solutions were stored at −20 °C and the working solutions were prepared immediately before the start of each experiment.Fig. 1

Chemical structure of 6-methylmercaptopurine riboside (6MMPr)

de Carvalho O.V., Félix D.M., de Camargo Tozato C., Fietto J.L., de Almeida M.R., Bressan G.C., Pena L.J, & Silva-Júnior A. (2017). 6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro. Virology Journal, 14, 124.

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Validating Anti-Hepatitis C Assay

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The FDA-approved anti-hepatitis C virus compounds sofosbuvir (β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine; MedChemExpress, Monmouth Junction, NJ, USA, cat. HY-15005) and ribavirin (1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide; Sigma Aldrich, St. Louis, MO, USA, cat. R9644) were used to validate the system. The inhibitor of viral protein glycosylation celgosivir (6-O-butanoyl castanospermine; Sigma Aldrich cat. SML2314), acting at the late stage of DENV replication, was used to evaluate the ability of the assay to discriminate between early and late antiviral effects. All reference compounds were supplied as powder; ribavirin and sofosbuvir were dissolved in 100% DMSO, while celgosivir was dissolved in bi-distilled sterile water.

Vicenti I., Dragoni F., Giannini A., Giammarino F., Spinicci M., Saladini F., Boccuto A, & Zazzi M. (2020). Development of a Cell-Based Immunodetection Assay for Simultaneous Screening of Antiviral Compounds Inhibiting Zika and Dengue Virus Replication. SLAS discovery : advancing life sciences R & D, 25(5).

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