Immunoradiometric assay

Manufactured by Fujirebio

Sourced in Japan

An immunoradiometric assay (IRMA) is a type of immunoassay that uses radioactive isotopes to quantify the concentration of a specific analyte in a sample. It involves the use of antibodies labeled with radioactive elements to detect and measure the target analyte in a sample.

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Lab products found in correlation

Enzymatic method, by Toyobo (2 mentions)

4 protocols using immunoradiometric assay

Serum Biomarkers of Liver Status

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Serum albumin, total bilirubin, creatinine, sodium, Mac-2 binding protein glycosylation isomer (M2BPGi, a hepatic fibrosis marker), and PT were measured using standard laboratory methods. Serum IGF-1 levels were evaluated using an immunoradiometric assay (Fujirebio, Tokyo, Japan).

Saeki C., Kanai T., Ueda K., Nakano M., Oikawa T., Torisu Y., Saruta M, & Tsubota A. (2023). Insulin-like growth factor 1 predicts decompensation and long-term prognosis in patients with compensated cirrhosis. Frontiers in Medicine, 10, 1233928.

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Serum Biomarkers in Fasting Patients

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Blood samples were obtained from each patient after overnight fasting. The following serum parameters were measured using routine laboratory methods: total bilirubin, albumin, and zinc levels, and prothrombin time/international normalized ratio. Serum BCAA and IGF-1 were measured using an enzymatic method (TOYOBO, Osaka, Japan) and an immunoradiometric assay (Fujirebio, Tokyo, Japan), respectively.

Saeki C., Kanai T., Nakano M., Oikawa T., Torisu Y., Saruta M, & Tsubota A. (2020). Low Serum Branched-chain Amino Acid and Insulin-Like Growth Factor-1 Levels Are Associated with Sarcopenia and Slow Gait Speed in Patients with Liver Cirrhosis. Journal of Clinical Medicine, 9(10), 3239.

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Serum Biomarkers for Sarcopenia

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Serum total bilirubin, albumin, and prothrombin time-international normalized ratio (PT-INR) were measured using standard laboratory methods. In addition, serum branched chain amino acid (BCAA) and insulin like growth factor 1 (IGF-1) were measured using an enzymatic method (TOYOBO, Osaka, Japan) and an immunoradiometric assay (Fujirebio, Tokyo, Japan), respectively. BCAA and IGF-1 are involved in muscle protein synthesis via the activation of the mammalian target of the rapamycin pathway and are associated with sarcopenia [11 (link),23 (link)].

Saeki C., Saito M., Kanai T., Nakano M., Oikawa T., Torisu Y., Saruta M, & Tsubota A. (2021). Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease. Journal of Clinical Medicine, 10(18), 4080.

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Osteoporosis Risk Factors in PBC

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This cross-sectional study included 127 consecutive patients with PBC who visited the Jikei University School of Medicine (Tokyo, Japan) and Fuji City General Hospital (Shizuoka, Japan) between 2017 and 2021. The enrolled patients were 40–90 years of age as per the recommendation of the FRAX. All patients with osteoporosis were treatment-naïve at the time of entry. PBC was diagnosed according to the criteria proposed by the Japanese Intractable Hepatobiliary Disease Study Group [19 (link)]. A questionnaire and medical record data were used to investigate previous and family history of fracture, smoking status, glucocorticoid use, complications of rheumatoid arthritis (RA) and alcohol intake. The serum IGF-1 level was evaluated using an immunoradiometric assay (Fujirebio, Tokyo, Japan). The levels of serum zinc and Mac-2 binding protein glycosylation isomer (M2BPGi; liver fibrosis marker) were measured using routine laboratory methods. The current study was performed in accordance with the 2013 Declaration of Helsinki, and was approved by the ethics committee of the Jikei University School of Medicine (approval no. 28-194) and Fuji City General Hospital (approval no. 162). Written informed consent was obtained from all participants.

Saeki C., Oikawa T., Ueda K., Nakano M., Torisu Y., Saruta M, & Tsubota A. (2022). Serum Insulin-Like Growth Factor 1 Levels, Facture Risk Assessment Tool Scores and Bone Disorders in Patients with Primary Biliary Cholangitis. Diagnostics, 12(8), 1957.

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