Atazanavir

Manufactured by Gilead Sciences

Atazanavir is an antiretroviral medication used in the treatment of HIV-1 infection. It functions as a protease inhibitor, which helps to prevent the HIV virus from replicating and spreading within the body.

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Lab products found in correlation

Emtricitabine, by Gilead Sciences (2 mentions) Tenofovir alafenamide, by Gilead Sciences (2 mentions) Bevirimat, by Gilead Sciences (1 mentions) Lenacapavir, by Gilead Sciences (1 mentions) Danoprevir, by Selleck Chemicals (1 mentions) Ym 53403, by Gilead Sciences (1 mentions) Efavirenz, by Gilead Sciences (1 mentions) Azidothymidine azt, by Merck Group (1 mentions) Puromycin, by Merck Group (1 mentions) Remdesivir, by Gilead Sciences (1 mentions) Elvitegravir, by Gilead Sciences (1 mentions)

2 protocols using atazanavir

Synthesis and Evaluation of HIV Inhibitors

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GS-CA1, PF74, emtricitabine (FTC), tenofovir (TFV), tenofovir alafenamide (TAF), elvitegravir (EVG), darunavir (DRV), atazanavir (ATV) and bevirimat (BVM) were synthesized at Gilead Sciences (Foster City, CA). Efavirenz (EFV), rilpivirine (RPV), dolutegravir (DTG) and raltegravir (RAL) were purchased from Toronto Research Chemicals, Curragh Chemistries, Porton Shanghai R&D Center and Expicor, respectively.

Yant S.R., Mulato A., Hansen D., Tse W.C., Niedziela-Majka A., Zhang J.R., Stepan G.J., Jin D., Wong M.H., Perreira J.M., Singer E., Papalia G.A., Hu E.Y., Zheng J., Lu B., Schroeder S.D., Chou K., Ahmadyar S., Liclican A., Yu H., Novikov N., Paoli E., Gonik D., Ram R.R., Hung M., McDougall W.M., Brass A.L., Sundquist W.I., Cihlar T, & Link J.O. (2019). A Highly Potent Long-Acting Small-Molecule HIV-1 Capsid Inhibitor with Efficacy in a Humanized Mouse Model. Nature medicine, 25(9), 1377-1384.

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Comprehensive Synthesis of Antiviral Compounds

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GS-9770, atazanavir (ATV), darunavir (DRV), amprenavir (APV), bictegravir (BIC), elvitegravir (EVG), lenacapavir (LEN), tenofovir alafenamide (TAF), emtricitabine (FTC), efavirenz (EFV), stavudine (d4T), the RSV control inhibitor YM-53403, and the SARS CoV-2 control inhibitor remdesivir (RDV) were all synthesized at Gilead Sciences (Foster City, CA). Ribavirin (RBV) was purchased from Combi-Blocks (San Diego, CA). The protein synthesis inhibitor puromycin and the HIV-positive control azidothymidine (AZT) were purchased from Sigma-Aldrich (St. Louis, MO). The HBV control inhibitor ND-654 was purchased from Pharmaron (Beijing, China). The HCV protease inhibitor danoprevir was purchased from Selleck Chemicals (Houston, TX). All drug stocks were prepared in 100% dimethyl sulfoxide (DMSO) and stored frozen at −20°C.

Mulato A., Lansdon E., Aoyama R., Voigt J., Lee M., Liclican A., Lee G., Singer E., Stafford B., Gong R., Murray B., Chan J., Lee J., Xu Y., Ahmadyar S., Gonzalez A., Cho A., Stepan G.J., Schmitz U., Schultz B., Marchand B., Brumshtein B., Wang R., Yu H., Cihlar T., Xu L, & Yant S.R. (2024). Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrobial Agents and Chemotherapy, 68(4), e01373-23.

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