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Signr1 apc

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SIGNR1-APC is a fluorescently-labeled antibody that binds to the SIGNR1 protein. SIGNR1 is a C-type lectin receptor expressed on macrophages and dendritic cells. The APC (Allophycocyanin) fluorescent label allows for flow cytometric detection and analysis of SIGNR1-expressing cells.

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Lab products found in correlation

Mhc 2 pacific blue, by Thermo Fisher Scientific (1 mentions) Anti mouse cd11c pe cy7, by Thermo Fisher Scientific (1 mentions)

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SIGNR1 (2 citations)

2 protocols using signr1 apc

1

Tracking Antigen-Presenting Cells in Mice

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BALB/c mice (n=15/group) were injected subcutaneously in the footpad with 3×1010 vector genomes of ID-VP02 encoding GFP, control ID-VP02 encoding the cancer-testis antigen NY-ESO-1, or left untreated. Four days later, the draining popliteal or nondraining cervical lymph nodes were pooled from 5 mice (3 pools per treatment group) and live (L/D singlet events (L/D NIR−, SSH=SSA) were analyzed for the presence of GFP. The phenotype of GFP+ cells was determined by costaining with anti-mouse CD11c-PE-Cy7 (eBioscience), MHC II-Pacific Blue (eBioscience), SIGNR5-PE (eBioscience), and SIGNR1-APC (eBioscience).
Odegard J.M., Kelley-Clarke B., Tareen S.U., Campbell D.J., Flynn P.A., Nicolai C.J., Slough M.M., Vin C.D., McGowan P.J., Nelson L.T., ter Meulen J., Dubensky TW J.r, & Robbins S.H. (2015). Virological and Preclinical Characterization of a Dendritic Cell Targeting, Integration-deficient Lentiviral Vector for Cancer Immunotherapy. Journal of Immunotherapy (Hagerstown, Md. : 1997), 38(2), 41-53.
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2

Quantifying Marginal Zone B Cells

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A histological examination was performed as described recently [19 ]. In addition, anti B220-eFluor570 (eBioscience, 41-0452-80, 1:200) or CD1d-Pacific Blue (BioLegend, 123516, 1:50) was applied to the frozen sections with CD169-FITC (AbD Serotec, MCA947F, 1:100) and SIGNR1-APC (eBioscience, 17-2093-80, 1:20). Image J (NIH, USA) was used to measure the MZ B cell region. One marginal zone B cell region was chosen per figure. The maximum width (along with the radial axis from around the center point of white pulp) of the MZ B region per figure was selected for data sampling. Between 3 and 4 mice per group were analyzed.
Matsuda T., Yanase S., Takaoka A, & Maruyama M. (2015). The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation. Immunity & Ageing : I & A, 12, 1.
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