Inveon

Manufactured by Siemens

Sourced in Germany, United States

The Inveon is a versatile and advanced pre-clinical imaging system designed for small animal research. It provides high-resolution imaging capabilities, supporting various modalities such as PET, SPECT, CT, and optical imaging. The Inveon is a robust and reliable platform that enables researchers to conduct non-invasive in vivo studies, facilitating the understanding of disease mechanisms and the evaluation of new therapies.

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Lab products found in correlation

Inveon research workplace, by Siemens (14 mentions) Inveon research workplace software, by Siemens (11 mentions) Inveon acquisition workplace, by Siemens (10 mentions) Pmod software, by PMOD Technologies (4 mentions) Vivoquant ver 4, by Invicro (4 mentions) Inveon acquisition workplace software, by Siemens (4 mentions) Microct, by MILabs (3 mentions) Inveon research workplace 4, by Siemens (3 mentions) In vivo multispectral imaging system fx, by Bruker (2 mentions) Accu chek performa, by Roche (2 mentions) Ncr nu nu male mice, by Charles River Laboratories (2 mentions) Isoflurane, by Abbott (2 mentions) L thyroxine l t4, by Merck Group (2 mentions) Asipro software, by Siemens (2 mentions) Gw4869, by Merck Group (2 mentions) Vasculocis, by PerkinElmer (2 mentions) Inveon micropet scanner, by Siemens (2 mentions) Microcat, by Siemens (2 mentions) Wizard2, by PerkinElmer (2 mentions) Micro pet scanner, by Siemens (2 mentions)

Close spelling variants of this product

Inveon micro PET/CT animal scanner (6 citations) Inveon Acquisition Workplace (IAW, (5 citations) Inveon microPET scanner (44 citations) Inveon Small Animal PET/SPECT/CT scanner (2 citations) INVEON PET/CT imaging system (4 citations) Inveon acquisition software (3 citations) Siemens Inveon PET module (2 citations) Inveon™ Hybrid Micro‐PET/CT Scanner (2 citations) Inveon software (29 citations) Inveon Acquisition Workspace (4 citations)

324 protocols using inveon

Micro-CT Analysis of Bone Regeneration

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Eight weeks after operation, the rats were sacrificed by intramuscular injection of overdose of Sumianxin II. All the 6 calvarial blocks of the sacrificed animals were harvested and immediately immersed into the 10% neutrally buffered formalin for fixation. Radiographic analysis of bone regeneration within the defects was performed using an X-ray unit (Vario^DG, Sirona), with the exposure time set at 0.03 seconds. After a 2-day fixation, the specimens were scanned along the sagittal direction though by micro-CT (Inveon, Siemens) with a resolution of 18 μm followed by an off-line reconstruction. After scanning, the selection of the area of interest was performed manually. Our preliminary study showed that the grey value of SMC-PHBHHx material was around −217, which was lower than water. The thresholding of mineralized bone was set at 500.
The following morphometric parameters obtained in direct mode were adopted to estimate the bone regeneration within the defects using software Siemens Inveon:

Relative bone volume (bone volume/tissue volume, BV/TV: %)

Trabecular number (Tb.N: 1/mm)

Trabecular separation (Tb.Sp: mm)

Trabecular thickness (Tb.Th: mm).

Liu T., Zhang X., Luo Y., Huang Y, & Wu G. (2016). Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects. Stem Cells International, 2016, 1416047.

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Micro-CT Analysis of Femur Bone Microstructure

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In order to evaluate the bone microstructure, the right femur was analyzed with high-resolution micro-CT using the micro-CT imaging system (Siemens, Inveon) according to the method described in the literature (Zhang et al., 2012 (link)). The femur was fixed in the centrifuge tube by the long axis, while the surrounding was filled with gauze. Quantitative parameters of bone microstructure including percent bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), structural model index (SMI) and bone mineral density (BMD) were measured. All the digital data, 2 D and 3 D images were provided by the built-in software of micro-CT (Siemens, Inveon).

Xi Y., Wang W., Ma L., Xu N., Shi C., Xu G., He H, & Pan W. (2022). Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats. Drug Delivery, 29(1), 2386-2402.

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Micro-CT Aortic Calcification Analysis

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Micro-CT analysis was performed to detect aortic calcification. The rats were anesthetized with isoflurane and scanned in a micro-CT scanner (Siemens inveon) at a resolution of 0.079 mm. Images were analyzed using the inveon research workplace software (Siemens inveon).

Zhang X., Li Y., Yang P., Liu X., Lu L., Chen Y., Zhong X., Li Z., Liu H., Ou C., Yan J, & Chen M. (2020). Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals. Arteriosclerosis, thrombosis, and vascular biology, 40(3).

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Multimodal PET Imaging in Parkinson's Rat Model

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Multimodal PET data were acquired from rats with unilateral 6-OHDA lesions of the medial forebrain bundle (n = 10) or sham lesions (n = 13). Rats received a single s.c. injection of saline 30 minutes before anesthesia induction with isofluorane and scanned before treatment on a Siemens Inveon (Siemens, Munich, Germany) at The Feinstein Institute for Medical Research. Following completion of a pre-treatment scan (PRE), 6-OHDA lesioned rats received two daily s.c. injections of levodopa (6 mg/kg) plus benserazide (12 mg/kg) for six days per week for a total of three weeks (21 days), which served as chronic levodopa treatment. AIMs were assessed according to well-validated criteria (See Behavioral assessment section below).
Upon completion of chronic treatment, animals underwent scanning under two conditions: after s.c. injections of saline (OFF) or levodopa (ON). OFF and ON scans occurred one week apart; half of the animals underwent OFF scanning first, and the other half underwent ON scanning first. During the week between the OFF and ON scanning sessions, after completion of their 21-day treatment and until the time of their transcardial perfusion, animals continued receiving one daily s.c. levodopa injection, for treatment and dyskinesia maintenance.

Lerner R.P., Francardo V., Fujita K., Bimpisidis Z., Jourdain V.A., Tang C.C., Dewey S.L., Chaly T., Cenci M.A, & Eidelberg D. (2017). Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia. Scientific Reports, 7, 16005.

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X-ray Imaging of Pressurized Vein Samples

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For the pretreatment optimization experiment, the vein sections were placed inside a PBS-filled 3.0 ml syringe serving as sample holder, and imaged on a Siemens Inveon instrument (Siemens Medical Solutions, PA, USA). Three-dimensional images of 23 × 23 × 55 mm field-of-view with 17 μm voxels were acquired using 701 projections with the source operating at 80 kVp and 120 μA, which took 60 min. In post-processing, the image contrast, for each vein section was quantified by,

c o n t r a s t = \frac{H_{t} - H_{b}}{H_{b}} .

where H_t and H_b were the average Hounsfield intensities of the tissue and the background, respectively.
For the pressurization experiment, the pretreated sample was rinsed in PBS, mounted on the pressurization apparatus, and imaged using the same protocol, except with reduced resolution (100 μm) to minimize scan time (18 min) to minimize possible contrast reduction due to diffusion. Jugular vein was first imaged in its unloaded state, which corresponded to approximately 60% shrinkage from its in situ length. The sample was then stretched to its estimated in situ length (100%) and imaged at each 2, 10, and 20 mmHg pressurization. Finally, the vein was stretched to 1.2 times its in situ length (120%), and imaged at the same pressure levels.

Gomez A.D., Zou H., Shiu Y.T, & Hsu E.W. (2014). Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis. Cardiovascular engineering and technology, 5(4), 359-370.

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In Vivo Mouse PET Imaging

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Mice were anesthetized by Matrx VMR, and ¹⁸F-FDG (185 MBq/kg) was given through the tail vein to initiate emission scan. Images were acquired on microPET (Siemens Inveon, Siemens Healthcare, Erlangen, Germany). To quantify ¹⁸F-FDG uptake on the last frame (corresponding to 40–60 min), the obtained tissue activity [counts (kBq)/ml] was divided by the injected activity in kBq per gram of body weight (185 kBq/g) to give a standardized uptake value. Animal maintenance and experimental procedures were approved by the Institutional Animal Care and Use Committee of Soochow University.

Ren Y.J., Wang X.H., Ji C., Guan Y.D., Lu X.J., Liu X.R., Zhang H.H., Guo L.C., Xu Q.H., Zhu W.D., Ming Z.J., Yang J.M., Cheng Y, & Zhang Y. (2017). Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol. Frontiers in Pharmacology, 8, 804.

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In Vivo PET Imaging of Tumor Targeting

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Nineteen days post-cell implantation, mice were anesthetized with 2% isoflurane, injected with 13–15 MBq of [¹⁸F]TFB in 50–150 μ L, and imaged dynamically with a microPET system (Siemens Inveon ©2011 by Siemens Medical Solutions USA, Inc.). Animal breathing rate and body temperature were monitored and maintained between 40 and 70 bpm and at 37 °C, respectively. Dynamic PET data were acquired for 40 min, and images were reconstructed using 2D filtered back projection. Quantification of PET signal was performed by manual segmentation of ROIs using Horos Project software v3.3.6. Maximum activity projections (MAPs) were generated. SUV was calculated with the below equation:

S U V (\frac{g}{m L}) = \frac{Pixelvalue (\frac{B q}{m L}) * weight (kg)}{Dose (Bq)} * 1000 (\frac{g}{kg})

Shalaby N., Kelly J., Martinez F., Fox M., Qi Q., Thiessen J., Hicks J., Scholl T.J, & Ronald J.A. (2022). A Human-derived Dual MRI/PET Reporter Gene System with High Translational Potential for Cell Tracking. Molecular imaging and biology, 24(2), 341-351.

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Microcomputed Tomography Lung Tissue Analysis

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Mice were initially anesthetized with 4% isoflurane gas and maintained with 2% isoflurane during whole-body micro-computed tomography (μCT) on a Siemens Inveon (Siemens Healthineers, Knoxville, TN) at the University of Wisconsin-Madison Small Animal Imaging and Radiotherapy Facility (SAIRF). Imaging was performed with the following parameters: 360 rotation degrees and rotation steps, binning 4, 250 ms exposure time, 80 kVp, 1 mA and ~105 μm resolution. Reconstructions were performed with no down-sampling using a Shepp-Logan filter and Hounsfield Unit (HU) calibration.
Image analysis assessing μCT lung tissue density was performed using Image Research Workplace similarly as before (Tian et al., 2019a (link)), by selecting and outlining 16 axial lung slices, starting with one immediately superior to the liver in n = 4–10 mice/condition. HU values associated with each voxel in the outlined volume were binned into indicated groups with lowest density voxels being in the < −600 HU group and highest density being between 0 and 100 HU. Percent voxels in each group of HU values were calculated based on the total number of voxels in the mouse lung. Individual axial slices were reconstructed in MATLAB and HU represented with a heat map for ease of visualization (Higham and Higham, 2016 ).

Bernau K., Skibba M., Leet J.P., Furey S., Gehl C., Li Y., Zhou J., Sandbo N, & Brasier A.R. (2022). Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis. Frontiers in molecular medicine, 2, 842558.

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Microcomputed Tomography Lung Tissue Analysis

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High-Resolution Micro-CT Imaging of Ischemic Limbs

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Sham or ischemic limbs were dissected at the head of the femur for individual scanning at high resolution using the micro-CT scanner in the Tri-modal Siemens Inveon (Siemens Healthcare, Hoffman Estates, IL) and the Inveon Acquisition Workplace (IAW) (version 1.5.28) software. Each ex vivo limb was placed on the imaging pallet with a field of view (FOV) of 18 x 25mm, positioned on the dorsal side, and scanned from thigh to ankle. CT scanning parameters were 80kVp and 300μA (voltage and current) with 0.5mm Al filtration. A 192° half scan was performed for 384 steps with an exposure time of 2100ms for each step. Center offset and dark/light calibrations were performed immediately prior to scanning for image optimization. The acquisition protocol included using a high system magnification with 2x2 binning to generate an isotropic voxel size of 17μm³. Raw data reconstruction was performed with a Shepp-Logan filter. Prior to image reconstruction, beam hardening correction was applied to ensure the quantitative accuracy of the Hounsfield Units (HUs) in the final images. Images are reconstructed with the standard Filtered Back-Projection (FBP) algorithm with no additional down-sampling of the raw data (binning of image voxels).

Adeyemo A., Johnson C., Stiene A., LaSance K., Qi Z., Lemen L, & Schultz J.E. (2020). Limb functional recovery is impaired in fibroblast growth factor-2 deficient (FGF2) mice despite chronic ischemia-induced vascular growth. Growth factors (Chur, Switzerland), 38(2), 75-93.

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