Multilink 8

Manufactured by Abbott

Sourced in United States

The MultiLink 8 is a compact and versatile laboratory equipment designed for various applications. It features eight independent channels that allow users to perform multiple experiments or procedures simultaneously. The device is capable of controlling and monitoring a range of parameters, making it a useful tool for researchers and technicians in various scientific fields.

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Lab products found in correlation

Xience prime, by Abbott (2 mentions) Promus, by Boston Scientific (1 mentions) Promus premier, by Boston Scientific (1 mentions) Resolute integrity, by Medtronic (1 mentions)

4 protocols using multilink 8

Stent Design and Side-Branch Access

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Stents were deployed on the bench in a silicone bifurcation model with an angle B7 of 30^° in a water bath. An 0.014" percutaneous interventional wire was passed through the side of the stent to the side‐branch then there was attempted balloon access to the side‐branch between struts. The balloon passage was recorded cine angiographically. The balloon tips were photographed microscopically before and after side‐branch access.
Side‐branch access was attempted with a total of 125 SC Trek balloons of 2.5 mm nominal diameter. For each stent design, we tested the passage of 5 balloons through the sides of 5 examples of 5 different stent designs which were Integrity (Medtronic), MultiLink 8 (Abbott Vascular), Onyx (Medtronic), Rebel (Boston), and Synergy (Boston). In addition, the stents were photographed to assess distortion after access by a balloon and the most damaged stents were imaged by microcomputed tomography (microCT). Ease of crossing was recorded as failed, encountering resistance or no resistance. Stent distortion was graded with moderate or severe distortion defined as ≥0.4 mm malapposition and/or ≥0.4 mm protrusion into the side branch after 2.5 mm Trek balloon side‐branch access.

Barkholt T.Ø., Ormiston J.A., Ding P., Webber B., Ubod B., Waite S, & Webster M.W. (2017). Coronary balloon catheter tip damage. A bench study of a clinical problem. Catheterization and Cardiovascular Interventions, 92(5), 883-889.

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Comparison of Coronary Stent Designs and Materials

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Coronary stents used in the study were Multi-Link8, Integrity, Omega and BioMatrix which were purchased from Abbott Vascular, Medtronic Ltd, Boston Scientific and Biosensors International Group Ltd, respectively (Table 1). Stainless steel 316L was used as the stent material for initial optimising conditions of laser surface engineering.Table 1

Coronary stents used in the study.

Table 1

Stents	Company	Image (the design)	Stent type	Strut material	Strut thickness (Measured on SEM images)
Omega	Boston Scientific	Image 1	BMS	Platinum chromium	77 μm
Integrity	Medtronic	Image 2	BMS	Cobalt chromium	97 μm
Multi-Link8	Abbott Vascular	Image 3	BMS	Cobalt chromium	73 μm
BioMatrix	Biosensors	Image 4	DES (PLA biodegradable, Biolimus A9)	316L Stainless steel	114 μm

Mirhosseini N., Li L., Liu Z., Mamas M., Fraser D, & Wang T. (2024). A comparison of endothelial cell growth on commercial coronary stents with and without laser surface texturing. Heliyon, 10(5), e26425.

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Comparison of DES, BMS, and UHS-Treated Stents

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We compared contemporary DES and BMS with UHS-treated stents. Our main analyses considered the Integrity BMS and the Resolute Integrity^® DES (3.0×18 mm platforms; Medtronic, Minneapolis, MN, USA). Pooled analyses using additional DES and BMS (XIENCE PRIME^® vs. MULTI-LINK 8™; Abbott Vascular, Santa Clara, CA, USA; PROMUS™ vs. Omega™; Boston Scientific, Marlborough, MA, USA) assessed consistency. For reporting, UHS, DES, and BMS labels reference the main treated-Integrity/Resolute/Integrity comparisons, respectively, unless indicated.
All UHS were prepared by surface treatment of corresponding BMS^{6 (link)}. The treatment reduces nickel and cobalt concentrations in the surface oxide and simultaneously removes organic contamination, leading to ultra-hydrophilic surfaces. The water contact angle on CoCr discs fell from 75°±5° to 10°±5° after treatment (Figure 1).

Kolandaivelu K., Bailey L., Buzzi S., Zucker A., Milleret V., Ziogas A., Ehrbar M., Khattab A.A., Stanley J.R., Wong G.K., Zani B., Markham P.M., Tzafriri A.R., Bhatt D.L, & Edelman E.R. (2017). Ultra-hydrophilic stent platforms promote early vascular healing and minimise late tissue response: a potential alternative to second-generation drug-eluting stents. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 12(17), 2148-2156.

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Comparison of Five Stent Platforms

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We compared five platforms: Omega (Boston Scientific), Multilink 8 (Abbott Vascular, Redwood City, California, USA), Integrity (Medtronic, Minneapolis, USA), Biomatrix Flex (Biosensors, Singapore) and Promus Premier (Boston Scientific). The former three bare metal stents were chosen as they are the identical platforms to the drug-eluting Promus and Taxus Element (Boston Scientific), Xience Prime (Abbott Vascular,) and Resolute Integrity (Medtronic) stents, respectively. The Biomatrix Flex and Promus Premier stents do not have bare metal equivalents. We chose 3.5 mm diameter stents for all platforms to avoid testing a mixture of small and large vessel platforms that exist for 3 mm diameter stents depending on the manufacturer. Stent length was greater than 18 mm in all cases. Table 1 shows the stent platform structures and characteristics for the stents used.

Choudhury T.R., Al-Saigh S., Burley S., Li L., Shakhshir N., Mirhosseini N., Wang T., Arnous S., Khan M.A., Mamas M.A, & Fraser D.G. (2017). Longitudinal deformation bench testing using a coronary artery model: a new standard?. Open Heart, 4(2), e000537.

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