Lats1 flox

Manufactured by Jackson ImmunoResearch

Lats1 flox is a lab equipment product designed for genetic manipulation. It is a DNA construct that contains loxP sites flanking the Lats1 gene, allowing for conditional deletion or modification of the Lats1 gene in target cells or organisms.

Automatically generated - may contain errors

Lab products found in correlation

Nf1 flox, by Jackson ImmunoResearch (2 mentions) Lats2 flox, by Jackson ImmunoResearch (2 mentions) Athymic nude mice foxn1, by Jackson ImmunoResearch (2 mentions) Hoxb7 cre, by Jackson ImmunoResearch (2 mentions) Yapflox, by Jackson ImmunoResearch (1 mentions) Taz flox, by Jackson ImmunoResearch (1 mentions) Rosa26 lacz, by Jackson ImmunoResearch (1 mentions) Rosa26yfp, by Jackson ImmunoResearch (1 mentions)

2 protocols using lats1 flox

Genotyping and Housing of Transgenic Mice

Cited 2 times

Check if the same lab product or an alternative is used in the 5 most similar protocols

Mice. The Nf1-KO (60 (link)), Nf1 flox (61 (link)), Hoxb7-Cre (62 (link)), Lats1 flox (63 (link)), Lats2 flox (63 (link)), Yap flox (64 (link)), Taz flox (65 (link)), and athymic nude mice (Foxn1^–/–) were purchased from Jackson Laboratory. Genotyping was performed by PCR as previously reported (60 (link)–65 (link)). All mice were housed in the Animal Care Facility at the UT Southwestern Medical Center (Dallas, Texas, USA).

Chen Z., Li S., Mo J., Hawley E., Wang Y., He Y., Brosseau J.P., Shipman T., Clapp D.W., Carroll T.J, & Le L.Q. (2020). Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling. JCI Insight, 5(20), e141514.

+ Open protocol

+ Expand

Genetically Engineered Mouse Models for NF1 and LATS Studies

Cited 2 times

Check if the same lab product or an alternative is used in the 5 most similar protocols

The Nf1 knockout (8 (link)), Nf1 flox (9 (link)), Hoxb7-Cre (47 (link)), Lats1 flox (48 (link)), Lats2 flox (48 (link)) ROSA26-YFP (49 (link)), ROSA26-lacZ and athymic nude mice (Foxn1^−/−) are available from Jackson Laboratory (Bar Harbor, ME). Genotyping was performed by PCR as previously reported (8 (link), 9 (link), 47 (link)–49 (link)). All mice were housed in the Animal Care Facility at The University of Texas Southwestern Medical Center (Dallas, TX), and all procedures were approved by Institutional Animal Care and Use Committee at University of Texas Southwestern Medical Center and conformed to NIH guidelines. Human subjects and cNF sample collection and use were approved by Institutional Review Board at University of Texas Southwestern Medical Center and conformed to NIH guidelines. Written informed consent was obtained from patients.

Chen Z., Mo J., Brosseau J.P., Shipman T., Wang Y., Liao C.P., Cooper J.M., Allaway R.J., Gosline S.J., Guinney J., Carroll T.J, & Le L.Q. (2018). Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the Hippo pathway. Cancer discovery, 9(1), 114-129.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!