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Adult female sprague dawley rats

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Adult female Sprague-Dawley rats are a widely used rodent model in biomedical research. They are characterized by their large size, docile temperament, and robust health. These rats are commonly utilized in studies related to physiology, pharmacology, and toxicology.

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Rodent chow 5001, by LabDiet (1 mentions) Snca knockout mice, by Jackson ImmunoResearch (1 mentions)

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Sprague-Dawley rats (3110 citations) Female Sprague-Dawley rats (164 citations) Sprague-Dawley (76 citations) Adult Sprague-Dawley rats (49 citations) Adult female rats (3 citations) Naïve adult female and male Sprague-Dawley rats (2 citations) Young-adult female Sprague-Dawley rats (2 citations)

29 protocols using adult female sprague dawley rats

1

Sprague-Dawley Rat Breeding and Care

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Adult female Sprague-Dawley rats weighing 200–250 g were purchased from the Vital River Laboratory Animal Technology (Beijing, China). The experimental animal protocols, including care, breeding, and operative procedures, were approved by the Animal Care and Use Committee of South China Agricultural University (2019-D096).
Wang N., Yang Y., Pang M., Du C., Chen Y., Li S., Tian Z., Feng F., Wang Y., Chen Z., Liu B, & Rong L. (2020). MicroRNA-135a-5p Promotes the Functional Recovery of Spinal Cord Injury by Targeting SP1 and ROCK. Molecular Therapy. Nucleic Acids, 22, 1063-1077.
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2

Sprague-Dawley Rat Housing and Care

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Adult female Sprague-Dawley rats (230 ± 10 g) were obtained from the Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China) and housed in a controlled environment with a 12-h dark/light cycle, regulated temperature, and humidity, with ad libitum access to water and food. The Institutional Animal Care and Use Committee of the Capital Medical University (Beijing, China) approved this study (Supplemental Approval No. AEEI-2023-154) on June 19, 2023, following the guidelines of the Committee for the Purpose of Control and Supervision of Experimentation on Animals (CPCSEA).
Ma Z., Liu T., Liu L., Pei Y., Wang T., Wang Z., Guan Y., Zhang X., Zhang Y, & Chen X. (2024). Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression. Neurochemical research.
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3

Sprague-Dawley Rat Pregnancy Study

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Adult female Sprague-Dawley rats (180–200g) and pregnant rats (15d) were obtained from Beijing Vital River Laboratory Animal Technology Co., Ltd (Beijing, China). All animal care and experimental protocols were approved by the Ethics Committee of the Characteristic Medical Center of Chinese People’s Armed Police Force. All animals were housed in individual cages on a 12h light/dark cycle with ad-libitum access to food and water.
Ma K., Xu H., Zhang J., Zhao F., Liang H., Sun H., Li P., Zhang S., Wang R, & Chen X. (2019). Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism. Aging (Albany NY), 11(24), 12278-12294.
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4

Sprague-Dawley Rat Housing Protocol

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Adult female Sprague-Dawley rats (female, 7-week old, Vital River Laboratory Animal Technology Co. Ltd, Beijing, China) weighing 180-250 g were housed at a constant temperature (23 ± 2 ℃) and humidity (50%-60%) under a regular 12-hour light/dark schedule. Tap water and standard rat chow were freely available. All animal experiments were done in accordance with international guidelines for the ethical use of experimental animals and were examined and approved by the Institutional Animal Care and Use Committee of China Academy of Chinese Medical Sciences (Beijing, China).
Wang L., Fu Y.B., Liu Y., Yang N.N., Ma S.M., Wang X.R., Huang J., Shi G.X., Yang J.W, & Liu C.Z. (2022). Moxibustion attenuates neurogenic detrusor overactivity in spinal cord injury rats by inhibiting M2/ATP/P2X3 pathway. Brain research, 1788.
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5

Sprague Dawley Rat Husbandry and Handling

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Adult female Sprague Dawley rats (Weight 259 ± 6.3 g) were obtained from Charles River Laboratories (Charles River Laboratories Inc., Sulzfeld, Germany). The animals were controlled at a 12 h dark-12 h light cycle with access to a standard rodent diet and water ad libitum. In order to limit stress, the same person handled the animals throughout the study and all experimental procedures were performed during the animals’ dark cycle.
Gaustad S.E., Kondratiev T.V., Eftedal I, & Tveita T. (2020). Continuous Hemodynamic Monitoring in an Intact Rat Model of Simulated Diving. Frontiers in Physiology, 10, 1597.
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6

Nicotine Addiction Study in Sprague-Dawley Rats

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Adult female Sprague-Dawley rats (Charles River Labs, Raleigh, NC, USA) were used for the current studies. At the start of the study the rats were 60-70 days old and were naïve to nicotine. They were housed in a vivarium facility next to the testing rooms on a 12:12 hr reverse day night cycle with lights off at 7:00 AM so that they were in their active phase during behavioral testing. All rats had ad lib access to water and were fed rodent chow once daily 30 min after their testing to keep them at approximately 85% of their ad lib body weight. All procedures used in this study were approved by the Duke University Animal Care and Use Committee. Each of the two studies used separate sets of rats. The rats were singly housed after catheter implant surgery to prevent cage mates from gnawing on the rats’ catheters.
Levin E.D., Slade C.W, & Rezvani A.H. (2018). Mutually Augmenting Interactions of Dextromethorphan and Sazetidine-A for Reducing Nicotine Self-administration in Rats. Pharmacology, biochemistry, and behavior, 166, 42-47.
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7

Sprague-Dawley Rat Housing and Care

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Adult female Sprague-Dawley rats (250–280 g; Charles River) were pair-housed in cages with wood bedding and had access to food and water ad libitum. The animal colony was maintained in a regular 12-h light/dark cycle (lights on 06:30). All procedures were approved by the University Health Network Animal Care Committee in accordance with guidelines and regulations set by the Canadian Council on Animal Care.
McKinnon C., De Snoo M.L., Gondard E., Neudorfer C., Chau H., Ngana S.G., O’Hara D.M., Brotchie J.M., Koprich J.B., Lozano A.M., Kalia L.V, & Kalia S.K. (2020). Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein. Acta Neuropathologica Communications, 8, 17.
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8

Sprague Dawley Rat Housing Protocol

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Adult female Sprague Dawley rats (Charles River), weighing 200–225 g at the beginning of the experiment, were housed under a 12/12 h light/dark cycle with water and food ad libitum. All animal studies were performed according to the Animal Protection Law and Directive 2010/63/EU of the European Commission. Animal protocols were approved by the Commission for Animal Experimentation of the Regional Council of Freiburg and the Commission for Animal Experimentation of the University Medical Center.
Winkler C., Reis J., Hoffmann N., Gellner A.K., Münkel C., Curado M.R., Furlanetti L., Garcia J., Döbrössy M.D, & Fritsch B. (2017). Anodal Transcranial Direct Current Stimulation Enhances Survival and Integration of Dopaminergic Cell Transplants in a Rat Parkinson Model. eNeuro, 4(5), ENEURO.0063-17.2017.
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9

Female Sprague-Dawley Rat Study

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Adult female Sprague-Dawley rats (230–300 g, N=17, Charles River Laboratories, Inc., Raleigh, NC, USA) were housed under standard laboratory conditions with ad libitum access to water and food. All experiments were performed in accordance with the NIH Guidelines for the Care and Use of Laboratory Animals and approved by the Integrated Laboratory Systems animal care and use committee. All efforts were made to minimize animal stress and to reduce the number of animals used.
Bae J., Johnston T.A., Chaiittianan R., Sutthanut K., Jay M, & Marson L. (2017). Characterization and in vivo efficacy of a heptapeptide ODT formulation for the treatment of neurogenic bladder dysfunction. International journal of pharmaceutics, 536(1), 397-404.
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10

Sprague Dawley Rat Husbandry Protocol

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Adult female Sprague Dawley rats (postnatal day [PND] 40 ± 2) were obtained from Charles River Laboratories International, Inc. (St. Constant, QC, Canada) and Harlan Laboratories, Inc. (Frederick, MD) (n = 29/vendor). Conditions in these colonies prior to arrival at the University of British Columbia (UBC) were previously reported27 (link). At UBC, rats were pair-housed in a single colony room, and maintained under controlled temperatures (21–22 °C), on a 12:12 hour light/dark cycle. Ad libitum access to standard laboratory chow (Purina Laboratory Rodent Diet #5001, Delta, BC, Canada) and water was provided throughout the experiment. All procedures were in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals, and approved by the University of British Columbia Animal Care Committee.
Bodnar T.S., Taves M.D., Lavigne K.M., Woodward T.S., Soma K.K, & Weinberg J. (2017). Differential activation of endocrine-immune networks by arthritis challenge: Insights from colony-specific responses. Scientific Reports, 7, 698.
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