Dimethyl sulfoxide dmso d6

Manufactured by Merck Group

Sourced in United States

Dimethyl sulfoxide (DMSO)-d6 is a deuterated solvent commonly used in nuclear magnetic resonance (NMR) spectroscopy. It is a clear, colorless liquid with a high boiling point and low viscosity. DMSO-d6 is a versatile solvent that can dissolve a wide range of organic and inorganic compounds, making it a useful tool for various analytical and research applications.

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12 protocols using dimethyl sulfoxide dmso d6

Chromatographic Techniques and Reagents

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Methanol (MeOH), n-hexane (n-hex., boiling point b.p. 60–80 °C), dichloromethane (DCM), ethyl acetate (EtOAC), H₂O₂, sulphuric acid, and sodium bicarbonate were purchased from El-Nasr Company for Pharmaceuticals and Chemicals, Cairo, Egypt. However, deuterated solvents, including chloroform (CDCl₃), and dimethyl sulfoxide (DMSO-d6) used for spectroscopic analyses were provided by Sigma-Aldrich (Saint Louis, MO, USA).
Column chromatography (CC) was carried out using silica gel 60 (63–200 μm, E. Merck, Sigma-Aldrich), while thin-layer chromatography (TLC) silica gel G F₂₅₄ (El-Nasr Company for Pharmaceuticals and Chemicals, Egypt) was employed for vacuum liquid chromatography (VLC). TLC was performed using pre-coated silica gel 60 GF254 plates (E. Merck, Darmstadt, Germany; 20 × 20 cm, 0.25 mm in thickness). Spots were visualized by heating at 110 °C, according to [43 ], after spraying with para-anisaldehyde (PAA) reagent (85:5:10:0.5 absolute EtOH: sulfuric acid: glacial acetic acid: para-anisaldehyde) [43 ].
In addition, all the kits used for the biological study were purchased by Biosystems SA Costa Brava 30, Barcelona (Spain) and DiaSys Diagnostic Systems GmbH, Holzheim, Germany.

Alsenani F., Ashour A.M., Alzubaidi M.A., Azmy A.F., Hetta M.H., Abu-Baih D.H., Elrehany M.A., Zayed A., Sayed A.M., Abdelmohsen U.R, & Elmaidomy A.H. (2021). Wound Healing Metabolites from Peters’ Elephant-Nose Fish Oil: An In Vivo Investigation Supported by In Vitro and In Silico Studies. Marine Drugs, 19(11), 605.

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Synthesis and Characterization of PEG-PLL-PLA Nanoparticles

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Methoxy polyethylene glycol amine (mPEG-NH2, molecular weight [MW] 5,000), N⁶-Carbobenzyloxy-l-lysine, 3,6-dimethyl-1,4-dioxite-2,5-dione, DMA, stannous octoate (Tin[II]2-ethylhexanoate), 4-(dimethylamino)pyridine (DMAP), succinic anhydride, pyridine, triethylamine (TEA), N-hydroxysuccinimide (NHS), N,N′-dicyclohexylcarbodiimide (DCC), 9,10-dimethylanthracene, trifluoroacetic acid (TFA), 33% HBr in acetic acid, anhydrous 1,4-dioxane, dimethyl sulfoxide (DMSO)-d₆, and anhydrous dimethylformamide (DMF) were purchased from Sigma-Aldrich (St Louis, MO, USA). Triphosgene was purchased from Alfa Aesar® Johnson Matthey Korea (Seoul, South Korea). Dichloromethane and toluene were purchased from Honeywell Burdick & Jackson® (Muskegon, MI, USA). Chlorin e6 (Ce6) was purchased from Frontier Scientific Inc. (Logan, UT, USA). All other chemicals used were of analytical grade. For cell culture, human cervical cancer KB cells were obtained from the Korean Cell Line Bank (KCLB, Seoul, South Korea). RPMI 1640 medium, fetal bovine serum (FBS), penicillin, and streptomycin were purchased from Welgene (Seoul, South Korea). Cell Counting Kit-8 (CCK-8) was obtained from Dojindo Molecular Technologies (Tokyo, Japan). PEG-PLL-PLA triblock copolyelectrolyte was prepared as described previously.17 (link)

Lim C., Sim T., Hoang N.H., Jung C.E., Lee E.S., Youn Y.S, & Oh K.T. (2017). A charge-reversible nanocarrier using PEG-PLL (-g-Ce6, DMA)-PLA for photodynamic therapy. International Journal of Nanomedicine, 12, 6185-6196.

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Characterization of Biogenic Amines

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All
reagents were obtained
from commercial suppliers and used without further purification. Epinephrine
hydrochloride (EPN·HCl), dopamine hydrochloride (DOP·HCl),
tyramine hydrochloride (TYR·HCl), dimethylsulfoxide (DMSO-d₆, 99.5 atom % D), and monoethanolamine (MEA,
98%, d = 1.012 g·mL^–1) were
purchased from Sigma-Aldrich. 2-Phenylethylamine hydrochloride (PEA·HCl,
99%) and (DMSO, 99.8%) were purchased from Fluka and TEDIA, respectively. l-3,4-dihydroxyphenylalanine (l-DOPA, 98.5%) was purchased
from S D Fine-Chem Ltd. The hydroxide bases NaOH and KOH (as pellets)
were obtained from Gainland Chemical Co. and Net Tech Ltd., respectively.
CO₂ (industrial grade) and N₂ (industrial grade)
were purchased from Advanced Technical Gases Co. (Amman, Jordan).

Assaf K.I., Qaroush A.K., Mustafa F.M., Alsoubani F., Pehl T.M., Troll C., Rieger B, & Eftaiha A.F. (2019). Biomaterials for CO2 Harvesting: From Regulatory Functions to Wet Scrubbing Applications. ACS Omega, 4(7), 11532-11539.

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Synthesis of Fluorescent Probes

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TEGDA, 3-amino-1,2-propanediol (3APD), 3-aminopropanol
(3AP), 5-aminopropanol (5AP), 1,4-diaminobutane, ciprofloxacin hydrochloride
(CIP) (98% pure), triethylamine (TEA), chloroacetyl chloride, ammonium
sulfate, sodium chloride, dimethyl sulfoxide (DMSO)-d₆ (99.5% D atom), and chloroform-d (99.8%
D atom) were obtained from Sigma-Aldrich and used without further
purification.

Kasza K., Richards B., Jones S., Romero M., Robertson S.N., Hardie K.R., Gurnani P., Cámara M, & Alexander C. (2024). Ciprofloxacin Poly(β-amino ester) Conjugates Enhance Antibiofilm Activity and Slow the Development of Resistance. ACS Applied Materials & Interfaces, 16(5), 5412-5425.

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Lignin Extraction from Black Liquor

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Lignin was extracted from black liquors using a method, which was developed by our laboratory and reported elsewhere^{41 (link)}. The black liquor, an as-it-is waste of the kraft pulping process, was obtained from Moorim P&P, South Korea. Methanol (99%), ε-caprolactone (CL, 99%), dibutyltin dilaurate (DBTDL, 99%), sulfuric acid (H₂SO₄, 99%), tetrahydrofuran (THF), and dimethyl sulfoxide (DMSO-d₆) were purchased from Sigma-Aldrich.

Park I.K., Sun H., Kim S.H., Kim Y., Kim G.E., Lee Y., Kim T., Choi H.R., Suhr J, & Nam J.D. (2019). Solvent-free bulk polymerization of lignin-polycaprolactone (PCL) copolymer and its thermoplastic characteristics. Scientific Reports, 9, 7033.

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Analytical Characterization of Anabolic Steroids

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The anabolic steroid analytes, buffer chemicals, Rhodamine 6G, tetrahydrofuran (THF), and dimethyl sulfoxide (DMSO)-d₆ were obtained from Sigma-Aldrich Chemical Company and the cyclodextrins were obtained from Tokyo Chemical Industry. All chemicals were used as received. All fluorescence measurements were performed using a Shimadzu RF 6000 spectrophotometer. The excitation and emission slit widths were set to 3.0 nm. All fluorescence spectra were integrated vs. wavenumber on the X-axis using OriginPro 2019 Version 9.60. All arrays were generated using SYSTAT Version 13.1. NMR studies were conducted using a Bruker 400 MHz NMR spectrometer and spectra were analyzed using MestReNova 14.1 software. Electrostatic potential map models were generated using Spartan' 18 software.

Haynes A.Z, & Levine M. (2020). Detection of anabolic steroids via cyclodextrin-promoted fluorescence modulation. RSC Advances, 10(42), 25108-25115.

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Deuterated Solvents for NMR Spectroscopy

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Heavy water (D₂O; ≥99.9
atom% D) and uniformly deuterated forms of chloroform (CDCl₃; ≥99.8 atom% D), dimethyl sulfoxide (DMSO-d₆; ≥99.8 atom% D), and 1,1,2,2-tetrachloroethane
(CD₂Cl₄; ≥99.5 atom% D) were from Sigma-Aldrich
(USA). Deuterated trifluoroacetic acid (TFA-d; ≥99.5
atom% D) was from Cambridge Isotope Laboratories (USA). CD₂Cl₄ was kept under inert atmosphere, and all solvents
were used as received.

Nelson T.F, & Ward C.P. (2023). Diffusion-Ordered Spectroscopy for Rapid and Facile Determination of Consumer Plastic Molecular Weight. Analytical Chemistry, 95(22), 8560-8568.

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Novel Psychoactive Substance Analysis

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FDU-PB-22 (1), FUB-PB-22, AB-CHMINACA, 5-fluoro-AMB, AM-2201 indazole analog (THJ-2201), NNEI indazole analog (MN-18), 4-methylbuphedrone, DL-4662, and 3,4-EDMA were purchased from Cayman Chemical (Ann Arbor, MI, USA); 2-methylpropyl N-(naphthalen-1-yl) carbamate (5) and diphenidine from Otava Ltd. (Toronto, Canada) and Tocris Bioscience (Bristol, UK), respectively. All other common chemicals and solvents were of analytical reagent grade or high-performance liquid chromatography (HPLC) grade. As solvents for nuclear magnetic resonance (NMR) analysis, chloroform-d₃ (99.96 %), methanol-d₄ (99.96 %), methanol-d₃ (99 %), pyridine-d₅ (99.96 %), and dimethyl sulfoxide (DMSO)-d₆ (99.96 %) were purchased from the ISOTEC division of Sigma-Aldrich (St. Louis, MO, USA).

Uchiyama N., Shimokawa Y., Kikura-Hanajiri R., Demizu Y., Goda Y, & Hakamatsuka T. (2015). A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products. Forensic Toxicology, 33(2), 244-259.

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Chromatographic Purification and Spectroscopic Analysis

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El-Nasr-Company for Pharmaceuticals-and Chemicals, Cairo, Egypt, supplied methanol (MeOH), dichloromethane (DCM), n-hexane-(n-hex., -boiling point b.p. 60–80 °C), ethyl acetate—(EtOAC), sulphuric-acid, and sodium-bicarbonate. Deuterated solvents, such as chloroform (CDCl₃) and dimethyl sulfoxide (DMSO-d6), were provided by Sigma-Aldrich for spectroscopic analyses (Saint-Louis, MO, USA).
Column chromatography- (CC) was performed using silica-gel 60 (63–200 m, E. Merck, Sigma-Aldrich), and vacuum liquid chromatography was performed using silica gel G F254 (El-Nasr-Company for Pharmaceuticals-and Chemicals, Egypt) (VLC). TLC was carried out on pre-coated silica gel 60-GF254 plates (E. Merck, Darmstadt, Germany; 20 20 cm, 0.25 mm thick). After spraying with para-anisaldehyde—(PAA)—reagent, spots were visualized by heating at 110 °C (85:5:10:0.5 absolute EtOH: sulfuric acid: glacial acetic acid: PAA). Furthermore, Biosystems-SA Costa Brava-30, Barcelona (Spain) and DiaSys Diagnostic Systems-GmbH, Holzheim, Germany—purchased all the kits-used in the biological study.

Elmaidomy A.H., Mohamed E.M., Aly H.F., Younis E.A., Shams S.G., Altemani F.H., Alzubaidi M.A., Almaghrabi M., Harbi A.A., Alsenani F., Sayed A.M, & Abdelmohsen U.R. (2022). Anti-Inflammatory and Antioxidant Properties of Malapterurus electricus Skin Fish Methanolic Extract in Arthritic Rats: Therapeutic and Protective Effects. Marine Drugs, 20(10), 639.

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Synthesis and Characterization of Silver Nanoparticles

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In the preparation of the complex, the following reagents were used: βCD hydrate (98%, 1134.98 g/mol), Mel (>95%, 305.2 g/mol), Dimethyl sulfoxide (DMSO)-d₆ (99.99% D, 84.17 g/mol), Phosphatidylcholine (99%), Dodecane (99%, 170.33 g/mol), Phosphate buffered saline (PBS) tablets, Thiopental (99%, 242.34 g/mol), and Evans Blue (75%, 960.81) provided by Sigma-Aldrich (Saint Louis, MO, USA). As solvents, ethanol p.a. and water for chromatography LiChrosolv^® brand Merck (Darmstadt, Germany) were employed. To obtain the AgNPs via magnetron sputtering, a silver foil of high purity (99.9%) was used as a precursor.

Sierpe R., Donoso-González O., Lang E., Noyong M., Simon U., Kogan M.J, & Yutronic N. (2023). Solid-State Formation of a Potential Melphalan Delivery Nanosystem Based on β-Cyclodextrin and Silver Nanoparticles. International Journal of Molecular Sciences, 24(4), 3990.

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