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Bevirimat

Manufactured by Gilead Sciences

Bevirimat is a laboratory product developed by Gilead Sciences. It is a small molecule that exhibits antiviral activity. The core function of Bevirimat is to inhibit the maturation of the HIV-1 virus.

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2 protocols using bevirimat

1

Synthesis and Evaluation of HIV Inhibitors

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GS-CA1, PF74, emtricitabine (FTC), tenofovir (TFV), tenofovir alafenamide (TAF), elvitegravir (EVG), darunavir (DRV), atazanavir (ATV) and bevirimat (BVM) were synthesized at Gilead Sciences (Foster City, CA). Efavirenz (EFV), rilpivirine (RPV), dolutegravir (DTG) and raltegravir (RAL) were purchased from Toronto Research Chemicals, Curragh Chemistries, Porton Shanghai R&D Center and Expicor, respectively.
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2

GS-6207 Characterization and Control ARVs

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GS-6207 was synthesized at Gilead Sciences, and chemical identity (1H-NMR, 13C-NMR and high-resolution mass-spectrometry spectra) and sample purity were established using reverse phase HPLC (Supplementary Information). Control ARVs emtricitabine (FTC), tenofovir alafenamide (TAF), elvitegravir (EVG), raltegravir (RAL), bictegravir (BIC), darunavir (DRV), atazanavir (ATV) and bevirimat (BVM) were synthesized at Gilead Sciences, whereas efavirenz (EFV) and dolutegravir (DTG) were purchased from Toronto Research Chemicals and Porton Shanghai R&D Center, respectively. Puromycin (a control compound for cytotoxicity assays) was purchased from Sigma-Aldrich.
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