R phenylephrine hcl

(±)-epinephrine HCl, (L)-norepinephrine bitartrate, (R)-phenylephrine HCl, sodium pentobarbital, Nile Red dye and solvents for drug delivery were all obtained from Sigma (St. Louis, MO). [³H] norepinephrine (13.9 Ci/mmol) and Ultima Gold^™ liquid scintillation cocktail were obtained from Perkin Elmer (Boston MA). Proteinase K (# 03 115887001) was from Roche. Female Golden Syrian hamsters (100 g) and ICR female mice (20–25 g) were purchased from Harlan Laboratories (Indianapolis, IN). Mice and hamsters were maintained on a 12 h light/dark cycle and provided water and Harlan 5305 (mice) or Harlan 2018 (hamsters) lab chow ad libitum. Animal procedures were approved by University of Wisconsin IACUC (Protocol # M0476).

(±)-Epinephrine HCl, (L)-norepinephrine bitartrate, (R)-phenylephrine HCl, sodium pentobarbital, N-nitroso-N-methylurea (MNU), resveratrol, Nile Red dye, spermine and solvents for drug delivery were all obtained from Sigma (St. Louis, MO). L-norepinephrine–HCl was obtained from ChemPacific (Baltimore, MD). Cyclophosphamide for injection was from Baxter (Deerfield, IL). Coal Black dye (#5006) was from Byrnes & Kiefer (Evans City, PA). The PrC-210 aminothiol was synthesized as described previously.¹⁸ Lactating female Sprague–Dawley rats with litters of 10-day-old pups were obtained from Harlan (Indianapolis, IN). Rats were maintained on 12-hr light/dark cycle and provided ad lib water and lab chow. All animal procedures were conducted according to a protocol (#M0476) approved by the University of Wisconsin Institutional Animal Care and Use Committee.

(±)-epinephrine HCl, (R)-phenylephrine HCl, Nile Red dye, cyclophosphamide, erioglaucine blue dye and solvents for drug delivery were all obtained from Sigma (St. Louis, MO). L-norepinephrine-HCl was obtained from ChemPacific (Baltimore, MD). Female B6D2F1 mice (20-21 g) were obtained from Jackson Labs (Bar Harbor, Maine), and female ICR mice (20-22g) were obtained from Harlan (Indianapolis, IN). Mice were maintained on 12 hr light/dark cycle and provided ad lib water and lab chow. All animal procedures were conducted according to a protocol (#M02632) approved by the University of Wisconsin Institutional Animal Care and Use Committee.