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Homecagescan

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HomeCageScan is a laboratory equipment designed for automated monitoring of animal behavior within a home cage environment. It utilizes advanced sensor technology to track and record various parameters related to the animal's movement and activity patterns.

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Lab products found in correlation

Fusion software, by Omnitech Electronics (1 mentions) Ethovision xt 12, by Noldus (1 mentions) Homecage software 3, by CleverSys (1 mentions)

9 protocols using homecagescan

1

Functional Outcomes Assessment Protocol

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Functional outcome was assessed as previously described,21 (link) via: 1) quantification of spontaneous cage activity in 1 hour videos, using Homecage Scan (CleverSys., Reston, VA USA); 2) adhesive removal test; 3) elevated body swing test.
Chen-Roetling J., Song W., Schipper H.M., Regan C.S, & Regan R.F. (2015). Astrocyte Overexpression of Heme Oxygenase-1 Improves Outcome after Intracerebral Hemorrhage. Stroke; a journal of cerebral circulation, 46(4), 1093-1098.
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2

Automated Sleep-Wake Behavior Monitoring

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Sleep-wake behavior was monitored in real time using HomeCageScan software (CleverSys, Inc., Reston, VA, USA), which allows for automated detection of rodent behaviors including sleep-wake based on movements, body postures, and duration/frequency of activities. The HomeCageScan software sleep detection algorithm has also been used previously for studying sleep-wake patterns in rodents (Hazra, et al., 2014 (link),Martinowich, et al., 2011 (link)). Each platform is fitted with an individual LED/IR sensitive camera capturing 640x480 pixels at 30 frames per sec, automatic 12 hr LED light/IR light controller for light/dark cycles, and video multiplexer for simultaneous multiple video acquisition to a Windows-based computer running HomeCageScan software. For statistical analysis, sleep-wake data were binned in one hour bins and exported to Excel. Because mice are nocturnal and sleep primarily during the light phase, sleep-wake behavior during the light phase was analyzed. Average sleep bout length was determined by normalizing the total duration of sleep time over number of awakens for each respective bin.
Hazra A., Corbett B.F., You J.C., Aschmies S., Zhao L., Li K., Lepore A.C., Marsh E.D, & Chin J. (2016). Corticothalamic network dysfunction and behavioral deficits in a mouse model of Alzheimer's disease. Neurobiology of aging, 44, 96-107.
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3

Quantifying Stereotypic Behaviors in Mice

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For piloting RAMH doses, saline or RAMH was injected intraperitoneally (IP). Mice were videotaped for 30 min using an automated system (HomeCageScan; CleverSys, Reston, VA, USA). Stereotypy was quantified from videotape by an observer (VP) blind to condition, as previously described.7 (link) The stereotypic behaviors expressed and considered for this kind of analysis were: sniffing, focused sniffing and licking/shaking. These observations were corroborated by measuring stereotypical beam-breaks with an automated system, as described below.
For locomotor activity monitoring, animals were habituated to the behavioral room for 60 min and then placed in an activity monitoring apparatus 47 cm L × 36.8 cm W × 20 cm H, Omnitech Electronics, Columbus, OH, USA) for 30 min before recording. Mice were injected with RAMH or saline, and/or other drugs 10 min into this period (that is, 20 min before starting recording). Activity was then recorded for 1 h. Ambulatory activity was defined as sequential infrared beam-breaks during locomotion. Stereotypical beam-breaks were defined as repetitive breaks of a single infrared beam within one second.26 (link), 27 (link), 28 (link), 29 (link) Beam-break data were collected and analyzed using Fusion software (Omnitech Electronics).
Rapanelli M., Frick L., Pogorelov V., Ohtsu H., Bito H, & Pittenger C. (2017). Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders. Translational Psychiatry, 7(1), e1013-.
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4

Automated Home Cage Behavioral Analysis

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HomeCageScan (Clever Sys, Reston, VA) was used as previously described (Veenstra-VanderWeele et al., 2012 (link); Zike et al., 2017 (link)) to assess time spent in various activities over a 24-hour period in the home cage, including sleeping, consuming food or water, rearing, grooming, hanging, remaining low, sniffing, stretching, twitching and walking. A two-way repeated measures ANOVA was used to analyze the array of behaviors (GraphPad Prism 6).
Anacker A.M., Moran J.T., Santarelli S., Forsberg C.G., Rogers T.D., Stanwood G.D., Hall B.J., Delpire E., Veenstra-VanderWeele J, & Saxe M.D. (2019). Enhanced social dominance and altered neuronal excitability in the prefrontal cortex of male KCC2b mutant mice. Autism research : official journal of the International Society for Autism Research, 12(5), 732-743.
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5

Evaluating Repetitive Behaviors in Mice

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To evaluate for the possibility of increased repetitive behaviors, DLX5/6Cre-Sema 3FF/F KO and wild-type littermate mice (N = 8–14/group) were video-recorded alone in their home cage for 24 h while maintaining their light–dark schedule as previously described [54 (link)]. Automated video analyses were conducted using HomeCage Scan (CleverSys, Inc., Reston, VA, USA) to index the time spent performing individual behaviors. The resulting data was condensed into 10 individual behaviors: distance traveled, eat/drink, hang, jump, rear, walk, groom, sleep/awake, and total behaviors. The total behavior time was not significantly different among the four genotypes. Bouts of hanging were defined as distinct periods of hanging from the wire cage lid separated by unique nonhanging behaviors. Statistical analysis was performed using ANOVA with post hoc Dunn’s multiple comparison test analysis.
Li Z., Jagadapillai R., Gozal E, & Barnes G. (2019). Deletion of Semaphorin 3F in Interneurons Is Associated with Decreased GABAergic Neurons, Autism-like Behavior, and Increased Oxidative Stress Cascades. Molecular Neurobiology, 56(8), 5520-5538.
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6

Automated Sleep-Wake Monitoring in Mice

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Sleep-wake monitoring was performed using HomeCageScan software (CleverSys, Inc), which allowed automated detection of homecage behaviors, including sleep-wake, based on movements, body postures, and duration and/or frequency of activities as previously described (39 (link)). Each home cage is placed on a platform fitted with an individual visible light- and infrared-sensitive camera (640 x 480 pixels at 30 frames/second), automatic light controller emitting visible or infrared light for 12-hour light-dark cycles, and a video output connected to a video multiplexer for simultaneous multiple video acquisition to a Windows-based computer running HomeCageScan software. For statistical analysis, sleep-wake data were binned in 1-hour intervals and processed through Microsoft Excel.
Jagirdar R., Fu C.H., Park J., Corbett B.F., Seibt F.M., Beierlein M, & Chin J. (2021). Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces Aβ accumulation in mice. Science translational medicine, 13(618), eabh4284.
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7

Automated Behavioral Quantification in Mice

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HomeCageScan (CleverSys Inc, Reston, VA) software program was used to quantify mouse behaviour in some experiments. The software program analyzes and quantifies 38 predetermined behaviors that were reclassified into 8 combined categories for statistical analysis in accordance with previous studies14 (link) (Supplementary Table 1, available at http://links.lww.com/PAIN/B220). In other experiments, EthoVision XT 12 (Noldus Information Technology, Wageningen, the Netherlands) was used to quantify hanging behavior and distance traveled by each mouse throughout the experiment. Using EthoVision, hanging behavior was defined as when the center of a mouse's body was located in the designated “Hang Zone” approximately 3 cm from the stainless steel cage lid and no paws were in contact with the cage floor. This analysis approach was verified by comparing hanging behavior measured by automated scoring to that measured by manual scoring. Zone parameters were validated in pilot studies before proceeding with experiments. There was a significant correlation (r = 0.99, n = 101, P < 0.001) between hanging behavior scored from automated and manual methods. EthoVision was used for all experiments except the initial characterization of homecage behaviors after SNI and CFA using HomeCageScan (Mogil lab).
Zhang H., Lecker I., Collymore C., Dokova A., Pham M.C., Rosen S.F., Crawhall-Duk H., Zain M., Valencia M., Filippini H.F., Li J., D'Souza A.J., Cho C., Michailidis V., Whissell P.D., Patel I., Steenland H.W., Virginia Lee W.J., Moayedi M., Sterley T.L., Bains J.S., Stratton J.A., Matyas J.R., Biernaskie J., Dubins D., Vukobradovic I., Bezginov A., Flenniken A.M., Martin L.J., Mogil J.S, & Bonin R.P. (2020). Cage-lid hanging behavior as a translationally relevant measure of pain in mice. Pain, 162(5), 1416-1425.
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8

Automated Scoring of Stereotypic Behavior

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Stereotypic time (grooming and sniffing) was scored from video using an automated system (Cleversys HomeCage Scan); we have previously shown that this measure correlates with manual scoring by a blinded observer (21 (link)). In an independent assay, stereotypical beam-breaks were defined as repetitive breaks of a single infrared beam within one second in the open field (42 (link)–44 (link)).
Rapanelli M., Frick L.R., Xu M., Groman S.M., Jindachomthong K., Tamamaki N., Tanahira C., Taylor J.R, & Pittenger C. (2017). Targeted interneuron depletion in the dorsal striatum produces autism-like behavioral abnormalities in male but not female mice. Biological psychiatry, 82(3), 194-203.
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9

Automated Mouse Behavior Monitoring

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Behavioral changes of mice were monitored and analyzed using the HomeCageScan (Clever Sys Inc.). The system had 4 cameras that monitored 4 cages, with each cage (191mm x 292mm x 127mm) containing one mouse. The behavior patterns were continuously recorded for 12 hr. After finishing the recording, the videos were analyzed by the Home Cage Software 3.0 (Clever Sys Inc.). For this behavioral study, 5–6 animals per group were used.
Lee J.H., Wei Z.Z., Cao W., Won S., Gu X., Winter M., Dix T.A., Wei L, & Yu S.P. (2016). Regulation of Therapeutic Hypothermia on Inflammatory Cytokines, Microglia Polarization, Migration and Functional Recovery after Ischemic Stroke in Mice. Neurobiology of disease, 96, 248-260.
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