Pp2a b56α

P-S6 and S6 were products of Cell Signaling Technology (NewEngland Biolabs, Pickering, ON). PP2A-B56α, 4EBP1, P-4EBP1, GFP (B-2), anti-β-actin, anti-Flag antibodies, and secondary antibodies were from Santa Cruz (Santa Cruz, Santa Cruz, CA). The PP2A inhibitor okadaic acid (OA) was from Calbiochem (EMD Chemicals Inc., Gibbstown, NJ); another PP2A inhibitor calyculin A (CA) was from Cell Signaling Technology (New England Bio labs). Rapamycin and puromycin were products of Sigma-Aldrich, Canada.

The antibodies for caspases-3, caspase-8, STAT3, pTyr705-STAT3, pSer727-STAT3, pSer70-bcl2, Bid, Bad, Akt, p38MAPK, pThr180/Tyr182-p38MAPK, cytochrome c, were from Cell Signaling Technology (Beverly, MA, USA). Antibodies for Bax and p21^CIP1 were from MBL (Nagoya, Japan). Antibodies for β-actin, Rb, Mcl-1, bcl-2, bcl-xL, p-gp130, JAK2, Cyclin D2, cyclin E, CDK2, CDK4, PKCα, PP2A/Aα, PP2A/B56α, PP2A/C were from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Antibodies for p-JAK2 or p27^kip1 were from Upstate (Waltham, MA, USA) or BD Transduction Laboratories, respectively. Anti-ERK1/2 or p-ERK1/2 antibody was from Sigma. Secondary antibodies conjugated with horseradish peroxidase were obtained from GE Healthcare (Tokyo, Japan).