Specific pathogen free balb c nu nu mice

Manufactured by Charles River Laboratories

Sourced in China

Specific pathogen free BALB/c nu/nu mice are a laboratory mouse strain that are athymic, or lacking a functional thymus gland. These mice are commonly used in research due to their impaired immune system, which allows for the study of human tumor xenografts and other research applications that require an immunocompromised animal model.

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BALB/c mice (1813 citations) BALB/c (373 citations) BALB/c nu/nu mice (163 citations) Nu/nu mice (158 citations) BALB/c nu/nu (73 citations) BALB/c-nu mice (49 citations) BALB/c-nu (21 citations) Specific-pathogen free BALB/c mice (11 citations) Specific pathogen-free BALB/c (2 citations)

2 protocols using specific pathogen free balb c nu nu mice

Establishment of Malignant Peritoneal Mesothelioma PDX Models

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Specific pathogen free BALB/c nu/nu mice, 4–5 weeks old, 16–18 g, were purchased from Beijing Vital River Laboratory Animal Technology Co.,
Ltd. (Beijing, China) and were raised individually in ventilated cages in a barrier environment at the temperature of 20–26°C, in the humidity of 40–70% at
Beijing Percans Oncology (Beijing, China). After a quarantine period of 7 days, mice were prepared for model establishment. The whole study procedures were
illustrated in Fig. 1.Fig. 1.

Experimental procedures and histopathological analysis of the established malignant peritoneal mesothelioma (MPM) patient-derived xenograft (PDX) models
and primary cell lines.

Yang Z.R., Chen Z.G., Ji Z.H., Lin Y.L., Zhang J., Ma R., Li Z., Jiang X., Chen Q., Du X.M, & Li Y. (2021). Establishment and histopathological study of patient-derived xenograft models and primary cell lines of epithelioid malignant peritoneal mesothelioma. Experimental Animals, 70(2), 225-235.

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Establishing BALB/c nu/nu Mouse Model

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Specific pathogen free BALB/c nu/nu mice, 4–5 weeks old, 16–18 g, were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China) and were raised individually in ventilated cages in a barrier environment at the temperature of 20°C–26°C, in the humidity of 40%–70% at Beijing Percans Oncology (Beijing, China). All experiments were performed under the guideline of the Declaration of Helsinki and Institutional Animal Care and Use Committee Health guidelines (IACUC20190306). And the animal study was reviewed and approved by the Scientific Research Ethics Committee of Beijing Shijitan Hospital, Capital Medical University.

Yang Z.R., Chen Z.G., Du X.M, & Li Y. (2020). Apatinib Mesylate Inhibits the Proliferation and Metastasis of Epithelioid Malignant Peritoneal Mesothelioma In Vitro and In Vivo. Frontiers in Oncology, 10, 585079.

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